Protein Alignment Egfr and ephb4a

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_571489.1
• Gene: ephb4a / 30688
• ZFINID: ZDB-GENE-990415-62
• Length: 987
• Species: Danio rerio
• Alignment Length: 910
• Identity: 206/910 - (22%)
• Similarity: 325/910 - (35%)
• Gaps: 296/910 - (32%)

  Fly   577 CNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTC------NGAGA 635
            |.|||.|   .||..|        ||....|:.::..:.          |||.|      .|:|.
Zfish   244 CGEDGQW---VDQPTT--------TCTCLPGFEASHGEL----------ECRACPVGLFKMGSGT 287

  Fly   636 DHCQECVHVRDGQHCVSECPKN-KYNDRG----VCRE--CHATCDG----CTGPKDTIGIGACTT 689
            ..|             |.||:| :..:.|    |||.  ..|..|.    ||.|..:      ..
Zfish   288 GPC-------------SVCPENSQTGETGSAACVCRSGFYRALSDSADTPCTRPPSS------PR 333

  Fly   690 CNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHE 754
            ..:..:|:.:..               .|:..|.:.|....|:....||.|......||
Zfish   334 SPVPQVNDTSLT---------------LEWSEPLDSGGRSDLSYSVECRMCSTPGSPCT------ 377

  Fly   755 QVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPE---------CNGCT-----GPGADDCK 805
             :||...:|:         |:.......:...:...|.         .||.:     ||..:...
Zfish   378 -LCSDGVNYR---------PSQTGIQGRRVSIWGLRPHTTYSFTVMALNGVSAQSQQGPAGETIN 432

  Fly   806 SCRNFKLFDANETGPYVNSTMFNCTS---------KCPLEMRHVNYQYTAIGPYCAASPPRSSK- 860
                   ...:...|.:.|.:...|:         ..|.:..:...||..  .||  ...|.|:
Zfish   433 -------ITTSPNVPVLVSGLRKSTATESSLTLYWNTPTQSHYRILQYQI--RYC--EKERGSEE 486

  Fly   861 -------------ITANL----------------------------------DVNMIFIITGAVL 878
                         :.::|                                  |.:...::||.::
Zfish   487 NSCHYMESNNNEVVLSDLRRATQYEVQVRARTFAGYGSFGKAILFRTLPDEDDSSSPLLVTGILI 551

  Fly   879 VPTICILCVV---TYICRQKQKAKKET--------------VKMTMALSGCED-SEPLRPSNIGA 925
            ...:.:|.:|   ...|.:||...|:.              ||:.:.....|| :|.:|..   |
Zfish   552 AMGMLLLIIVIGAAIYCIRKQNNYKDPELSDKNGQYLMGQGVKVYIDPFTYEDPNEAVREF---A 613

  Fly   926 NLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIP------VAIKELLKSTGAESSEE 984
            ....:..||..|     |:|.|.||.|.:|       .::||      ||||.|......:...:
Zfish   614 KEIDVSCVKIEE-----VIGAGEFGEVCRG-------RLRIPGKKENYVAIKTLKGGYTDKQRRD 666

  Fly   985 FLREAYIMASVEHVNLLKLLAVCMSS-QMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIA 1048
            ||.||.||...:|.|::.|..:..:| .:|::|:.|..|.|..::|.|..:.....|:.....||
Zfish   667 FLAEASIMGQFQHPNIIHLEGIITASCPVMILTEFMENGALDSFLRLNDGQFTPIQLVGMLRGIA 731

  Fly  1049 KGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLL---SSDSNEYKAAGGKMPIKWLALE 1110
            .||.||.|...|||||||||:||.:..:.|::||||::.|   |||.....:.|||:||:|.|.|
Zfish   732 SGMKYLSEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLQENSSDPTYTSSLGGKIPIRWTAPE 796

  Fly  1111 CIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLS 1175
            .|..|.||..||||::|:.:||:::||:||:.::..:|:.:.||...:|..|..||..::..:|.
Zfish   797 AIAFRKFTCASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCSTYLHQLMLD 861

  Fly  1176 CWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPA---YTSQDEKDLIRKLAPTTDGS 1237
            ||..:...||.|..:.:..               ||..|.||   .|:|:
Zfish   862 CWQKERTARPRFANIVSAL---------------DKLIRNPASLKITAQE--------------- 896

  Fly  1238 EAIAEPDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLD 1302
                          ..||||        |.|::  :.|.          |.||...||.....:.
Zfish   897 --------------GAGPSH--------PLLDQ--RSPL----------TPSSCGTVGDWLRAIK 927

  Fly  1303 LPVDEDDYLMPTCQPGPNNNNNINNPNQNNMAAVGVA-AGYMDLIGVPVSVDNPEYLLNAQTLGV 1366
            :...|:.:|    |.|..:...:.:.|..::..:|:. ||:...|           |.:.:.||:
Zfish   928 MERYEETFL----QAGYTSMQLVTHINTEDLLRLGITLAGHQKKI-----------LSSIEALGI 977

  Fly  1367  1366
            Zfish   978  977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032
		GF_recep_IV	572..684	CDD:464344	31/123 (25%)
		FU	662..716	CDD:214589	10/63 (16%)
		GF_recep_IV	740..>834	CDD:464344	15/116 (13%)
		PTKc_EGFR_like	930..1208	CDD:270648	98/287 (34%)
ephb4a	NP_571489.1	EphR_LBD	26..199	CDD:470656
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	319..340		4/26 (15%)
		fn3	339..418	CDD:394996	16/109 (15%)
		FN3	440..533	CDD:238020	11/96 (11%)
		EphA2_TM	547..618	CDD:464211	15/73 (21%)
		PTKc_EphR_B	616..884	CDD:173638	100/294 (34%)
		SAM_EPH-B4	914..980	CDD:188953	16/79 (20%)