DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and Ror2

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_017455997.1 Gene:Ror2 / 306782 RGDID:1305275 Length:950 Species:Rattus norvegicus


Alignment Length:1035 Identity:237/1035 - (22%)
Similarity:364/1035 - (35%) Gaps:338/1035 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   515 LEMRNLKQISSGSVVIQHNRDLCYVS-----NIRW-----PAIQKEPE----QKVWVNENLR-AD 564
            ||..|...|..|...|.|    |.|:     |:||     |.:| ||.    :|......|| .|
  Rat    72 LEPVNNITIVQGQTAILH----CKVAGNPPPNVRWLKNDAPVVQ-EPRRVIIRKTEYGSRLRIQD 131

  Fly   565 L---------C-EKNG--TICS-------------------DQCNEDGCWGAGTDQC-----LTC 593
            |         | ..||  ||.:                   |...|||.       |     :.|
  Rat   132 LDTTDTGYYQCVATNGLKTITATGVLYVRLGPTHSPNHNFQDDDQEDGF-------CQPYRGIAC 189

  Fly   594 KNFNFNGTCIADC----GYISN----AYKFDNRTCKICHPECRTCNGAGADHCQE------CVHV 644
            ..|..|.|...|.    |.|.|    |:.....:..:            :|.|.:      |..|
  Rat   190 ARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHL------------SDQCSQFAIPSFCHFV 242

  Fly   645 RDGQHCVSECPKNKYNDRGVCR-ECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKD 708
            .......|..||    .|.:|| ||.                                   :|::
  Rat   243 FPLCDARSRAPK----PRELCRDECE-----------------------------------VLEN 268

  Fly   709 DKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCH--PLCEL-----CTNYG--------YHEQVCS 758
            |.|...|.....:|.       :..|....||.  |:.|.     |...|        ||:....
  Rat   269 DLCRQEYTIARSNPL-------ILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNG 326

  Fly   759 KCTHY-------KRREQCE---TECPADHYTDEEQRECFQCHPECNG----CTGPGADDCKSCRN 809
            ..|.|       |...||:   .:.|..|.....:      .||..|    |..||         
  Rat   327 SGTDYRGMASTTKSGHQCQPWALQHPHSHRLSSTE------FPELGGGHAYCRNPG--------- 376

  Fly   810 FKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIIT 874
                 ....||:           |..:.::|..:...:.|   .||...||      :.:::|:.
  Rat   377 -----GQMEGPW-----------CFTQNKNVRVELCDVPP---CSPRDGSK------MGILYILV 416

  Fly   875 GAVLVPTI--CILCVVTYICRQKQKAKKET-VKMTMALSGCEDSE-PLRPSNIGANLCKLRIVKD 935
            .::.:|.:  |:..:|. :||.||||...| .:..:..|..:|.| ||...:..|   ||:.:..
  Rat   417 PSIAIPLVIACLFFLVC-MCRNKQKASASTPQRRQLMASPSQDMEMPLISQHKQA---KLKEISL 477

  Fly   936 AELRKGGVLGMGAFGRVYKG-VWVP-EGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHV 998
            :.:|....||...||:|||| ::.| .||..:: ||||.|.........|||.:||.:.|.::|.
  Rat   478 STVRFMEELGEDRFGKVYKGHLFGPAPGEPTQV-VAIKTLKDKAEGPLREEFRQEAMLRARLQHP 541

  Fly   999 NLLKLLAVCMSSQMMLITQLMPLGCLLDY-----------VRNNRDKIGS--------KAL---- 1040
            |::.||.|        :|:..||..:..|           :|:....:||        .||    
  Rat   542 NIVCLLGV--------VTKDQPLSMVFSYCCHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPD 598

  Fly  1041 -LNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGK-MP 1103
             ::...|||.||.:|....:||:|||.|||||.....|:|:|.||.:.:.| ::.||..|.. :|
  Rat   599 FVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYS-ADYYKLMGNSLLP 662

  Fly  1104 IKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLD 1168
            |:|::.|.:....|:..||:|::||.:||:.::|.:|:.....:|:.::|.....|..|:.|...
  Rat   663 IRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAW 727

  Fly  1169 IYCTLLSCWHLDAAMRPTFKQL------------------------TTVFAEFARDP------GR 1203
            :|..::.||:...:.||.||.:                        ||..:..:..|      .|
  Rat   728 VYALMIECWNEFPSGRPRFKDIHGRLRSWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNAR 792

  Fly  1204 YLAIPGDKFTRLPAYTSQDEKDLIRKLAP------TTDGSEAIAEPDDYLQPKAAPGPSHRTDCT 1262
            |:| |..|....|.......|..||.|.|      ..:|.:.:.....|| |...|.........
  Rat   793 YMA-PKQKAQPFPQPQFIPMKGQIRPLVPPAQLYIPVNGYQPVPAYGAYL-PNFYPVQIPMQMAP 855

  Fly  1263 DEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLDLPVDEDDYLMPTCQPGPNNNNNINN 1327
            .::|.  :....||:.:|.:|...|                     .|:  |..|        :|
  Rat   856 QQVPP--QMVPKPSSHHSGSGSTST---------------------GYV--TTAP--------SN 887

  Fly  1328 PNQNNMAAVGVAAGYMDLIGVPV----------------SVDNPEYLLNAQTLGVGESPI 1371
            .:..:.||: ::.|..|:..:|.                ||...|.|.::.||.|.|:.:
  Rat   888 TSVADRAAL-LSEGTEDVQNMPEDVAQSPVQEAEEEEEGSVPETELLGDSDTLQVNEAHV 946

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032 13/41 (32%)
GF_recep_IV 572..684 CDD:464344 27/150 (18%)
FU 662..716 CDD:214589 8/54 (15%)
GF_recep_IV 740..>834 CDD:464344 22/122 (18%)
PTKc_EGFR_like 930..1208 CDD:270648 95/334 (28%)
Ror2XP_017455997.1 I-set 71..159 CDD:400151 26/91 (29%)
Ig strand B 86..90 CDD:409353 2/7 (29%)
Ig strand C 99..103 CDD:409353 2/3 (67%)
Ig strand E 125..129 CDD:409353 1/3 (33%)
Ig strand F 139..144 CDD:409353 1/4 (25%)
Ig strand G 152..155 CDD:409353 0/2 (0%)
CRD_TK_ROR2 177..316 CDD:143577 37/203 (18%)
KR 321..402 CDD:214527 19/114 (17%)
Protein Kinases, catalytic domain 473..756 CDD:473864 88/292 (30%)
Blue background indicates that the domain is not in the aligned region.

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