Protein Alignment Egfr and Mst1r

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_063121316.1
• Gene: Mst1r / 300999
• RGDID: 1306465
• Length: 1446
• Species: Rattus norvegicus
• Alignment Length: 1441
• Identity: 289/1441 - (20%)
• Similarity: 443/1441 - (30%)
• Gaps: 613/1441 - (42%)

  Fly   263 ESCTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFD 327
            ||.|.|..|:  ..||     ||: .|..|. :||                |...|.:
  Rat    90 ESLTTGPIGD--PGCQ-----TCA-SCGPGP-HGP----------------PNDTDTL------- 122

  Fly   328 EGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNG--------ACVRSCPQD 384
                             ..|:|.......:.|:|....|..|.|...|        ||:.|...:
  Rat   123 -----------------VLVMEPGLPALVSCGSTLQGRCFLHELEPQGEALHLAAPACLFSASNN 170

  Fly   385 KMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDG-----------NIRILDQTFSGFQ 438
            |.:...:||..:     ....|||:..|:...|...:.:|.           :||.|....||||
  Rat   171 KPEACTDCVASH-----LGTRVTVVEQGHASYFYVASSLDPELAASFSPRSVSIRRLKSDTSGFQ 230

  Fly   439 DVYANYTMGPRYI-----------------------PLD-------------------------- 454
            ..:.:.::.|:|:                       |:|
  Rat   231 PGFPSLSVLPKYLASYLIKYVHSFHSGDFVYFLTVQPMDVRSPPSALQTRLVRLNAIEPEIGDYR 295

  Fly   455 ------------------PERLE--------------------------------VFSTVKEITG 469
                              |:.|:                                ||..||:.:.
  Rat   296 ELVLDCHFAPKRRRRSGAPKSLQAYQVLQAAHSAPVDAKLALDLSISEGQEVLFGVFVAVKDSSS 360

  Fly   470 YLNI---------------EGT----HP-------QFRNLSYFRN-----------LETIHGRQL 497
            ..|.               ||.    ||       :.|.|.:|:.           ....|...|
  Rat   361 GPNSVVCAFPINHLDNLIEEGVERCCHPSNSSLLTRRRGLDFFQTPSFCPNPPGAPSSRCHYFPL 425

  Fly   498 M-ESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQH--NRD------------------------ 535
            | ...|..:.:....|.|:::..|.....|:|.:.|  ..|
  Rat   426 MVHDSFTRVDLFNGLLGSVKVTALHVTRLGNVTVAHMGTEDGRILQVGPSLSHLVPQSCPLPLLF 490

  Fly   536 ------------------LCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGC 582
                              |.||||....:..:...|.|   ..|..||...:|    ||..:...
  Rat   491 FSELTCLSQVEIARSLNYLLYVSNFSLGSSGQPVHQDV---SRLGNDLLFASG----DQVFKVPI 548

  Fly   583 WGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPEC---RTCNGA-GADHCQECV- 642
            .|.|....|||      ..|:       .|.:|  ..|..|...|   :.|.|: ..|:|...:
  Rat   549 QGPGCGHFLTC------WRCL-------RAQRF--MGCGWCGDRCGRQKECPGSWQQDYCPPEIT 598

  Fly   643 ----H------------------------VRDGQHCV----SEC---PKNKYNDRGVCR------ 666
                |                        |.:|.|.:    |.|   ||:....|...:
  Rat   599 EFHPHSGPLRGTTRLTLCGSNFYLRPDGVVPEGTHQITVGQSPCRLLPKDSSTRRSGSQKEFIEE 663

  Fly   667 -ECHATCDGCTGPKDTIGIGACTTCNLAIINNDA----TVKRCLLKDDKCPDGYFWEYVHPQEQG 726
             ||...      |.:|..:|. |..:|.|.|..|    .|:...:::|       :.::.|. ..
  Rat   664 LECELE------PLETQAVGT-TNISLLITNMPAGKHFRVEGVSVRED-------FSFMEPM-LT 713

  Fly   727 SLKPLAG--------------------RAV------CRKCHPLCE---LCT-------------- 748
            |:||..|                    |||      || ...:.|   ||.
  Rat   714 SIKPDFGPRAGGTYLTLEGQSLSVGTSRAVLVNGTQCR-LEQVSEEKILCVTPPGAGTASVPLRL 777

  Fly   749 NYGYHEQVCSKCTHYKR-------REQC-------------------------------ETECPA 775
            ..|..|...|:..|||.       ..:|                               |:.|..
  Rat   778 QIGGAEVRGSRTFHYKEDPIVLDISPKCGYSGSHVMVHGQHLTSAWHLTVSFNDGQSIVESRCAG 842

  Fly   776 DHYTDEEQREC-----FQCHPE-------------CNGCTGPGADDCKSCRNFKLF---DANETG 819
            ...  |:|.:|     ...:|:             ..|.|.||         |:..   ....||
  Rat   843 QFL--EQQHQCRLPEYMVRNPQGWATGNLSLWGDGAAGFTLPG---------FRFLPPPSLPRTG 896

  Fly   820 P-------------YVN-STMFNCTS--------KCPLEMR------------------------ 838
            |             |:. ..:.:|.:        .|..|:|
  Rat   897 PVLLKPEEHSVKVEYIGLGAVADCVTVNVTVGGEVCQHELRGDVVICPLPPSLQLGKDGVPLQVC 961

  Fly   839 -----HVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKA 898
                 |:      :|....:.|.|:|:.|..:.:..:.::...:.:..:|          ..::.
  Rat   962 VDGGCHI------LGQVVRSGPGRASQRTLLIALLALILLVAGLAIALVC----------NSRRR 1010

  Fly   899 KKETV----------------KMTMAL--SGCEDSEPL--RPSN--------IGANLCKLRI--- 932
            ||:.|                .|::::  ||.:....|  ||.|        .|.::..||.
  Rat  1011 KKQLVLTPNLDDLTSRDLSPRAMSLSIFRSGSDYRNGLASRPPNHEESSEGQDGTSVPLLRTDSI 1075

  Fly   933 ------------VKD-------AELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTG 978
                        |||       ..:....|:|.|.||.||.|.:..|.:| :|..|||.|.:.|.
  Rat  1076 RLQDLDKMLLAEVKDVLIPHEQVVIHTDQVIGKGHFGVVYHGEYTDEAQN-QIHCAIKSLSRITE 1139

  Fly   979 AESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMM--LITQLMPLGCLLDYVRNNR--------- 1032
            .:..|.||||..||..:.|.|:|.|:.:.:..:.:  ::...|..|.||.::|:.:
  Rat  1140 VQEVEAFLREGLIMRGLHHPNILALIGIMLPPEGLPRVLLPYMRHGDLLRFIRSPQRVSAQCPGW 1204

  Fly  1033 -----------DKIGS-------KALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKI 1079
                       ..:.|       |.|:::..|:|.||.||.|::.|||||||||.::.....||:
  Rat  1205 GVSASTHLCRCSPVSSCPQNPTVKDLISFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKV 1269

  Fly  1080 TDFGLAKLLSSDSNEYKA---AGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPH 1141
            .|||||:.: .|...|..   ...::|:||:|||.::...||:|||||:|||.:|||||.|..|:
  Rat  1270 ADFGLARGI-LDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPY 1333

  Fly  1142 ENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLA 1206
            .:|...|:...:..|.:|.|||.|...:|..:|.||..|.|.||||:.|.....:.|.      :
  Rat  1334 PHIDPFDLSHFLVQGRRLPQPEYCPDSLYQVMLRCWEADPAARPTFRALVLEVEQVAS------S 1392

  Fly  1207 IPGDKFTRLPA 1217
            :.||.:.:|.|
  Rat  1393 LLGDHYVQLTA 1403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614	29/145 (20%)
		Recep_L_domain	419..547	CDD:460032	42/319 (13%)
		GF_recep_IV	572..684	CDD:464344	30/158 (19%)
		FU	662..716	CDD:214589	13/64 (20%)
		GF_recep_IV	740..>834	CDD:464344	26/191 (14%)
		PTKc_EGFR_like	930..1208	CDD:270648	108/331 (33%)
Mst1r	XP_063121316.1	None