DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egfr and Fras1

DIOPT Version :9

Sequence 1:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_038947596.1	Gene:	Fras1 / 289486	RGDID:	1306516	Length:	4014	Species:	Rattus norvegicus

Alignment Length:	841	Identity:	195/841 - (23%)
Similarity:	276/841 - (32%)	Gaps:	296/841 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 APERECPKC---------HES--CTHGC-WGEGP---KNCQKFSKLTCS-PQCAGGRCYGPKPRE 301
            ||.:.||:|         ||.  ..||. |..||   .:| .:.::.|| .||....| ||:..|
  Rat    78 APNQCCPQCAPRTPGSCHHEGKIREHGTEWASGPCTLCSC-TYGEVRCSHQQCTPLSC-GPQELE 140

  Fly   302 ------CC--------------HLF---------------CAGG--------------------- 310
                  ||              |:|               |..|
  Rat   141 FLAEGHCCPICVGTGKPCSDDGHVFQDGEDWPLSHCAKCVCRNGLTQCFTAQCQPLFCNQDEIVV 205

  Fly   311 ------CTGPTQKDCIACKNFFDEG-----------VC--------KEECPPMRKYNPTTYVLET 350
                  |:..:.:.|......::.|           :|        |:.|||:|.         .
  Rat   206 RVPGKCCSQCSSRSCSTAGQVYEHGEQWKEDACTLCMCDQGQVRCHKQACPPLRC---------A 261

  Fly   351 NPEGKYAYGATCVKECPGHLLRDNGACVRSCP-------QDKMDKGGECVPC----------NGP 398
            ..:.|..:...|.:||.        :.||||.       ||:|.||..|..|          .|.
  Rat   262 KGQSKARHHGQCCEECV--------SPVRSCSSGGVLRYQDEMWKGSACEFCVCDQGQVTCQTGE 318

  Fly   399 CPKT--CPGVTVLH-----AGNIDSFRNCTVIDGNIRILDQTFSGFQDV--YANYTMGP------ 448
            |.|.  .||..::|     .....|..:..|.:....|:....|..:.|  ...:..||
  Rat   319 CAKVACAPGEELVHLEGKCCPECISRNDYCVYEEKAEIMSSNSSEIKHVPEGKKWEEGPCKLCEC 383

  Fly   449 ------RYIPLDPERLEVFSTVKEITGYLNIEGT----HPQFRNLSY--------------FRNL 489
                  .|.|..|. ..|.:....:.|....:.|    ||.....|:              .:|.
  Rat   384 REAQVTCYEPSCPP-CPVATLAMAVKGQCCPDCTPVHCHPDCLTCSHSPEHCDLCQDPTKLLQNG 447

  Fly   490 ETIHGRQLMESMFAALAIV--------------KSSLYSLEMRNLKQISS---GSVVIQHNRDLC 537
            ..:....|......:|.:.              .|.|..|.|:..:.:|:   |.....|:..:|
  Rat   448 RCVPSCGLGFYQAGSLCLACQPQCSTCTSSLECSSCLPPLLMQQGQCVSTCGDGFYQDHHSCAVC 512

  Fly   538 YVSNIR-WPAIQK------EPEQKVWVNENLRADLCE---------KNGT--ICSDQCNEDGCWG 584
            :.|... |...:|      :|   :.|   ||...||         :.||  .|...|.  .| |
  Rat   513 HESCAGCWGPTEKHCVACRDP---LLV---LRDGSCENTCGNGFYNRQGTCVACDQSCK--SC-G 568

  Fly   585 AGTDQCLTC--KNFNFNGTCIADC--GYISNAYKFDNRTCKICHPECRTCNGAGADHCQECVH-- 643
            ..:.:||||  |...::||||::|  ||.::|    ...||:||..|.:|:|..|.||..|||
  Rat   569 PSSPRCLTCAEKTVLYDGTCISECPRGYYADA----TGRCKVCHVSCASCSGPAAAHCTACVHPQ 629

  Fly   644 -VRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLK 707
             :|.| ||:..|....|.|.|:|..||.:|..|.||:.|    .||.|
  Rat   630 VLRQG-HCLPSCGGGFYPDHGICGACHGSCHTCVGPEPT----HCTQC----------------- 672

  Fly   708 DDKCPDGYFWEYVHPQEQ----------GSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKC-- 760
              |.|:.......|..|.          |:...|....:|..|||.|.||.  |...:.|:.|
  Rat   673 --KKPEAGLQVEQHSGENVPYGKCVSQCGAHFYLESTGLCEACHPSCLLCE--GKSPRNCTGCGP 733

  Fly   761 THYKRREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNST 825
            .|.....:|.::||..|:..|  ..|.:|||.|..|.||...||.||.           |::..:
  Rat   734 AHVLLAGRCLSQCPETHFNQE--GTCTECHPSCRQCHGPLESDCVSCH-----------PHLTLS 785

  Fly   826 MFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILC 886
            ...|.:.|..|      |:..:..|||...|......|||.      .||:|     |:.|
  Rat   786 SGRCKASCKDE------QFLNLVGYCADCHPLCQHCVANLQ------DTGSV-----CLKC 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	28/177 (16%)
		GF_recep_IV	572..684	CDD:291509	46/118 (39%)
		FU	573..>606	CDD:238021	13/34 (38%)
		FU	617..659	CDD:214589	18/44 (41%)
		FU	662..716	CDD:214589	14/53 (26%)
		FU	739..786	CDD:238021	15/48 (31%)
		FU	784..834	CDD:214589	14/49 (29%)
		PTKc_EGFR_like	930..1208	CDD:270648
		STYKc	938..1194	CDD:214568
		Recep_L_domain	128..239	CDD:279382
		Furin-like	253..401	CDD:279142	53/261 (20%)
		FU	255..292	CDD:214589	15/52 (29%)
		FU	302..345	CDD:238021	15/117 (13%)
Fras1	XP_038947596.1	VWC	27..86	CDD:214564	4/7 (57%)
		VWC	94..151	CDD:278520	18/58 (31%)
		VWC	158..>198	CDD:327433	4/39 (10%)
		VWC	224..277	CDD:278520	9/61 (15%)
		VWC	284..341	CDD:214564	14/56 (25%)
		VWC	368..415	CDD:327433	7/47 (15%)
		VSP	405..780	CDD:146106	110/426 (26%)
		VSP	728..1059	CDD:146106	37/132 (28%)
		FU	1045..1086	CDD:214589
		Cadherin_3	1101..1197	CDD:406568
		Cadherin_3	1202..1309	CDD:406568
		Cadherin_3	1313..1440	CDD:406568
		Cadherin_3	1448..1576	CDD:406568
		Cadherin_3	1579..1693	CDD:406568
		Cadherin_3	1703..1813	CDD:406568
		Cadherin_3	1822..1940	CDD:406568
		Cadherin_3	1943..2061	CDD:406568
		Cadherin_3	2081..2181	CDD:406568
		Cadherin_3	2188..2295	CDD:406568
		Cadherin_3	2297..2408	CDD:406568
		Cadherin_3	2427..2539	CDD:406568
		Calx-beta	2555..2652	CDD:413355
		Calx-beta	2677..2763	CDD:413355
		caca	<2782..>3049	CDD:273296
		Calx-beta	3041..3135	CDD:413355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900