Protein Alignment Egfr and EPHA10

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001092909.1
• Gene: EPHA10 / 284656
• HGNCID: 19987
• Length: 1008
• Species: Homo sapiens
• Alignment Length: 982
• Identity: 208/982 - (21%)
• Similarity: 354/982 - (36%)
• Gaps: 277/982 - (28%)

  Fly   416 SFRNCTVIDGNIRILDQTFSGFQ-DVYANYTMG--------PRYI------------PLDPERLE 459
            :.|:|:.|.|......:||:.:. :..|:...|        ||.|            .|...:::
Human   108 TLRDCSSIPGAAGTCKETFNVYYLETEADLGRGRPRLGGSRPRKIDTIAADESFTQGDLGERKMK 172

  Fly   460 VFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQIS 524
            :.:.|:|| |.|:..|.|..|:::.                  |.:|:|...:|..:.|
Human   173 LNTEVREI-GPLSRRGFHLAFQDVG------------------ACVALVSVRVYYKQCR------ 212

  Fly   525 SGSVVIQHNRDLCYVSNIR----WPAIQKEPEQKVWVNENLRADLCEKNGTICSD---------- 575
                           :.:|    :||.         ..|:..:.|.|..||..:.
Human   213 ---------------ATVRGLATFPAT---------AAESAFSTLVEVAGTCVAHSEGEPGSPPR 253

  Fly   576 -QCNEDGCWGAGTDQCLTCKNFNFNGTCIADC--GYISNAYKFDNRTCKICHPECRTC------- 630
             .|..||.|.....:|.....|...|.....|  |:    ||...|     .|.|..|
Human   254 MHCGADGEWLVPVGRCSCSAGFQERGDFCEACPPGF----YKVSPR-----RPLCSPCPEHSRAL 309

  Fly   631 -NGAGADHCQE-------------CVH----VRDGQHCVSECP---------------KNKYNDR 662
             |.:....||:             |..    .||.|:.:|..|               ::.....
Human   310 ENASTFCVCQDSYARSPTDPPSASCTRPPSAPRDLQYSLSRSPLVLRLRWLPPADSGGRSDVTYS 374

  Fly   663 GVCRECHATCDGCTGPKDTIGIGACTTC--NLAIINNDATVKR---CLLKDDKCPDGYFWEYVHP 722
            .:|..|     |..||     .|||..|  .:|.:...|.::.   .||            ::.|
Human   375 LLCLRC-----GREGP-----AGACEPCGPRVAFLPRQAGLRERAATLL------------HLRP 417

  Fly   723 QEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECF 787
            ..:.:::..|...|   ..|.....|.|.   ||           ...|...|....||.:|:
Human   418 GARYTVRVAALNGV---SGPAAAAGTTYA---QV-----------TVSTGPGAPWEEDEIRRD-- 463

  Fly   788 QCHPECNGCT--------GPGADDCK-SCRNFKLFDANET-------GPYVNSTMFNCTSKCPLE 836
            :..|:....:        .|||:|.: ..|.::...:.:|       .|.|..|.....::...:
Human   464 RVEPQSVSLSWREPIPAGAPGANDTEYEIRYYEKGQSEQTYSMVKTGAPTVTVTNLKPATRYVFQ 528

  Fly   837 MR-------------HVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVV 888
            :|             :.:.:...:|...:.|..:|..|...:......::.|:|:    .:|.:.
Human   529 IRAASPGPSWEAQSFNPSIEVQTLGEAASGSRDQSPAIVVTVVTISALLVLGSVM----SVLAIW 589

  Fly   889 TYICRQKQKAKKETVKMTMALSGCEDSE--------PLR-----PSNIGANLCKLRI------VK 934
            ...|...:..           ....|.|        |.|     |.:.|..|..:.:      .|
Human   590 RRPCSYGKGG-----------GDAHDEEELYFHFKVPTRRTFLDPQSCGDLLQAVHLFAKELDAK 643

  Fly   935 DAELRKGGVLGMGAFGRVYKG-VWVPEGENVKIPVAIKELLKSTGAESSE-EFLREAYIMASVEH 997
            ...|.:.  ||.|.||.:..| :.:|..:.:.:.|   .:|:.:.::|.. .||.||..:...:|
Human   644 SVTLERS--LGGGRFGELCCGCLQLPGRQELLVAV---HMLRDSASDSQRLGFLAEALTLGQFDH 703

  Fly   998 VNLLKLL-AVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVH 1061
            .::::|. .|...|.:|::|:.|..|.|..::|.:..::.:..|:.....:|..|.||.|...||
Human   704 SHIVRLEGVVTRGSTLMIVTEYMSHGALDGFLRRHEGQLVAGQLMGLLPGLASAMKYLSEMGYVH 768

  Fly  1062 RDLAARNVLVQTPSLVKITDFGLAKLLSSDSNE--YKAAGGKMPIKWLALECIRNRVFTSKSDVW 1124
            |.||||:|||.:..:.||:.||..   ..|.:|  |....|:.|..|.|.|.::...|:|.||||
Human   769 RGLAARHVLVSSDLVCKISGFGRG---PRDRSEAVYTTMSGRSPALWAAPETLQFGHFSSASDVW 830

  Fly  1125 AFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQ 1189
            :||:.:||::.||:||:.::..:|:...:|.|.:|..|..|...::..:|.||..|...||.|.|
Human   831 SFGIIMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPNLLHRLMLDCWQKDPGERPRFSQ 895

  Fly  1190 LTTVFAEFARDPG----RYLAIP------GDK-FTRLPAYTS----QDEKDLIR---KLAPTTDG 1236
            :.::.::..:||.    .....|      .|: |:..|::.|    .:..||.|   ..|....|
Human   896 IHSILSKMVQDPEPPKCALTTCPRPPTPLADRAFSTFPSFGSVGAWLEALDLCRYKDSFAAAGYG 960

  Fly  1237 S-EAIAE 1242
            | ||:||
Human   961 SLEAVAE 967

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032	26/152 (17%)
		GF_recep_IV	572..684	CDD:464344	29/164 (18%)
		FU	662..716	CDD:214589	13/58 (22%)
		GF_recep_IV	740..>834	CDD:464344	20/109 (18%)
		PTKc_EGFR_like	930..1208	CDD:270648	84/292 (29%)
EPHA10	NP_001092909.1	EphR_LBD_A10	35..210	CDD:198455	24/120 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	322..342		1/19 (5%)
		fn3	339..431	CDD:394996	20/113 (18%)
		FN3	451..531	CDD:214495	14/81 (17%)
		EphA2_TM	569..642	CDD:464211	11/87 (13%)
		PTKc_EphR_A10	639..904	CDD:133195	82/272 (30%)
		SAM_superfamily	929..998	CDD:472832	13/39 (33%)