Protein Alignment Egfr and Ephb1

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_775623.3
• Gene: Ephb1 / 270190
• MGIID: 1096337
• Length: 984
• Species: Mus musculus
• Alignment Length: 1031
• Identity: 231/1031 - (22%)
• Similarity: 365/1031 - (35%)
• Gaps: 348/1031 - (33%)

  Fly   414 IDSFRNCTVIDGN-IRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTH 477
            |.:::.|.|.:.| ...|..||...:..:..||             |:..||::.:...|:.|:.
Mouse    55 IRTYQVCNVFEPNQNNWLLTTFINRRGAHRIYT-------------EMRFTVRDCSSLPNVPGSC 106

  Fly   478 PQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLK-----------QISSGSVVIQ 531
            .:..||.|:   ||       :|:.|    .|.|.:..|...||           |:..|..:::
Mouse   107 KETFNLYYY---ET-------DSVIA----TKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMK 157

  Fly   532 HNRDL--------------------CY-VSNIR-----WPAIQKE----PEQKVWVNENLRADLC 566
            .|.::                    |. :.::|     .|:|.:.    ||.......   ..|.
Mouse   158 VNTEVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAES---TSLV 219

  Fly   567 EKNGTICSD----------QCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCK 621
            ...||...:          .||.||.|.....:| |||.           ||
Mouse   220 IARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGRC-TCKP-----------GY------------- 259

  Fly   622 ICHPE----CRTCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRG-----VCRECHATCD---- 673
              .||    |:.|........||      .:.| |.||.|..:...     .||..:...|
Mouse   260 --EPENSVACKACPAGTFKASQE------AEGC-SHCPSNSRSPSEASPICTCRTGYYRADFDPP 315

  Fly   674 --GCT----GPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLA 732
              .||    ||::.|          :|:|..:.:               .|:..|:|.|....:.
Mouse   316 EVACTSVPSGPRNVI----------SIVNETSII---------------LEWHPPRETGGRDDVT 355

  Fly   733 GRAVCRKCHPLCELCTNYGYHEQVCSKC---THYKRREQCETECPAD------H--YTDEEQREC 786
            ...:|:||..          ..:.||:|   ..:..|:...|||...      |  ||.:.|
Mouse   356 YNIICKKCRA----------DRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQ--- 407

  Fly   787 FQCHPECNGCT--GPGADDCKSCRNFKLFDANETGP-------YVNSTMFNCTSKCP-------- 834
                 ..||.:  .|......|..    ...|:..|       .|::||.:.|...|
Mouse   408 -----AINGVSSKSPFPPQHVSVN----ITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNGI 463

  Fly   835 ---LEMRHVNYQYTAIGPYCAASPPRSSKITANLD---VNMIFII-------------------- 873
               .|:|:...::....    :|..||...||.:|   ..|::::
Mouse   464 ILDYEIRYYEKEHNEFN----SSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQ 524

  Fly   874 --------------------TGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPL 918
                                :.|..|..:..|..::.:|.:|:...||...          |:.|
Mouse   525 TLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAAY----------SDKL 579

  Fly   919 RPSNIGANLCKLRIVKD-----------AELRK---------GGVLGMGAFGRVYKGVWVPEGEN 963
            :..:.|.....::|..|           .|..|         ..|:|.|.||.||||       .
Mouse   580 QHYSTGRGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKG-------R 637

  Fly   964 VKIP------VAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQ-MMLITQLMPL 1021
            :|:|      ||||.|......:...:||.||.||...:|.|:::|..|...|: :|:||:.|..
Mouse   638 LKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMEN 702

  Fly  1022 GCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAK 1086
            |.|..::|.|..:.....|:.....||.||.||.|...|||||||||:||.:..:.|::||||::
Mouse   703 GALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSR 767

  Fly  1087 LLSSDSNE--YKAA-GGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKD 1148
            .|..|:::  |.:: |||:|::|.|.|.|..|.|||.||||::|:.:||:::||:||:.::..:|
Mouse   768 YLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQD 832

  Fly  1149 IPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDP------GRYLAI 1207
            :.:.||...:|..|..|...::..:|.||..|...||.|.::.....:..|:|      ....|:
Mouse   833 VINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAV 897

  Fly  1208 PGDK-----------------------------------FTRLPAYTSQDEKDLIR 1228
            |...                                   ||.|...|....:||:|
Mouse   898 PSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLR 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032	31/165 (19%)
		GF_recep_IV	572..684	CDD:464344	30/140 (21%)
		FU	662..716	CDD:214589	10/68 (15%)
		GF_recep_IV	740..>834	CDD:464344	22/113 (19%)
		PTKc_EGFR_like	930..1208	CDD:270648	105/313 (34%)
Ephb1	NP_775623.3	EphR_LBD_B1	20..195	CDD:198444	31/166 (19%)
		fn3	326..412	CDD:394996	23/128 (18%)
		fn3	435..518	CDD:394996	14/86 (16%)
		EphA2_TM	542..616	CDD:464211	14/83 (17%)
		PTKc_EphR_B	614..882	CDD:173638	98/274 (36%)
		SAM_EPH-B1	908..975	CDD:188950	7/46 (15%)
		PDZ-binding. /evidence=ECO:0000255	982..984