Protein Alignment Egfr and Igf1r

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_008757722.1
• Gene: Igf1r / 25718
• RGDID: 2869
• Length: 1372
• Species: Rattus norvegicus
• Alignment Length: 1542
• Identity: 331/1542 - (21%)
• Similarity: 540/1542 - (35%)
• Gaps: 540/1542 - (35%)

  Fly    85 PTSLEDKNKNEFVKGKIC-IGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDL 148
            |||           |:|| .|...|        :.|:.|: |..|||.::|.|.:..:.......
  Rat    27 PTS-----------GEICGPGIDIR--------NDYQQLK-RLENCTVIEGFLHILLISKAEDYR 71

  Fly   149 SF-LDNIREVTGYILISHV---DVKKVVFPKLQIIRGRTLFSLSVEEEKYALFV-TYSKMYTLEI 208
            |: ...:..:|.|:|:..|   :....:||.|.:|||..||      ..|||.: ..:.:..:.:
  Rat    72 SYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLF------YNYALVIFEMTNLKDIGL 130

  Fly   209 PDLRDVLNGQVGFHNNYNLCHMRTIQWS---EIVSNGTDAYYNYDF-TAPEREC----------- 258
            .:||::..|.:....|.:||::.||.||   :.|||      ||.. ..|.:||
  Rat   131 YNLRNITRGAIRIEKNADLCYLSTIDWSLILDAVSN------NYIVGNKPPKECGDLCPGTLEEK 189

  Fly   259 PKCHESC-----THGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQK- 317
            |.|.::.     .:.||  ....|||.    |...|....|  .:..||||..|.|.|..|...
  Rat   190 PMCEKTTINNEYNYRCW--TTNRCQKM----CPSVCGKRAC--TENNECCHPECLGSCHTPDDNT 246

  Fly   318 DCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAY-GATCV-------------KECPG 368
            .|:||::::.:|||...|||                |.|.: |..||             .:..|
  Rat   247 TCVACRHYYYKGVCVPACPP----------------GTYRFEGWRCVDRDFCANIPNAESSDSDG 295

  Fly   369 HLLRDNGACVRSCPQDKMDKGGE---CVPCNGPCPKTCPGVTVLHAGNIDS------FRNCTVID 424
            .::.| |.|::.||...:....:   |:||.|||||.| |........|||      .:.||::.
  Rat   296 FVIHD-GECMQECPSGFIRNSTQSMYCIPCEGPCPKVC-GDEEKKTKTIDSVTSAQMLQGCTILK 358

  Fly   425 GNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNL 489
            ||:.|..:..:.......|: ||               .::.:|||:.|..:| ...:||:.:||
  Rat   359 GNLLINIRRGNNIASELENF-MG---------------LIEVVTGYVKIRHSH-ALVSLSFLKNL 406

  Fly   490 ETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQ----------ISSGSVVIQHNRDLCYVSNIRW 544
            ..|.|.:.:|..:        |.|.|:.:||:|          :.||.:....|..||
  Rat   407 RLILGEEQLEGNY--------SFYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLC------- 456

  Fly   545 PAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYI 609
                        |:|..|.:  |..||           .|..:...:..:|.....:|.:|....
  Rat   457 ------------VSEIYRME--EVTGT-----------KGRQSKGDINTRNNGERASCESDVLRF 496

  Fly   610 SNAYKFDNRTCKICH----PECRTCNGAGADHCQECVHVR----------DGQH-CVS------- 652
            ::...:.||.....|    |:.|       |.....|:.:          |||. |.|
  Rat   497 TSTTTWKNRIIITWHRYRPPDYR-------DLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVD 554

  Fly   653 -ECPKNKYNDRGVCRECHATCDGCTGPKD----TIGIGACTTCNLAIINND-------------- 698
             :.|.||..:.|:...         |.|.    .:.:.|.|   |.::.||
  Rat   555 VDLPPNKEGEPGILLH---------GLKPWTQYAVYVKAVT---LTMVENDHIRGAKSEILYIRT 607

  Fly   699 -ATV--------------KRCLLK--DDKCPDGYFWEYV-----HPQE----QGSLKPLAGRAVC 737
             |:|              .:.::|  ....|:|....|:     .||:    :.:....|.:...
  Rat   608 NASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFRHNYCSKADKIPI 672

  Fly   738 RKC------------HPLCELCTNYGYHEQVCSKCTHYKRREQCETE------------------ 772
            ||.            :|..|:|   |..:..|..|...:..:|.|.|
  Rat   673 RKYADGTIDVEEVTENPKTEVC---GGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFV 734

  Fly   773 -------------------------CPADHY--TDEEQREC----FQCHPE-------------- 792
                                     ..||.|  ||.|:.|.    |:...:
  Rat   735 PRPERRRRDVLQVANTTMSSRSRNTTVADTYNITDPEEFETEYPFFESRVDNKERTVISNLRPFT 799

  Fly   793 --------CN------GCT-----------GPGADD----------------------------- 803
                    ||      ||:           ..||||
  Rat   800 LYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLI 864

  Fly   804 ----------------CKSCRNFKLFDA---NETGPYVNSTMFNCTS-------------KCPLE 836
                            |.|.:.::.:..   |...|...:.....||             ..|.:
  Rat   865 LMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVPAK 929

  Fly   837 MRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKE 901
            ..:.|:.:..|.                |.|.::.|:.|         |.::.|:..:|:...:.
  Rat   930 TTYENFMHLIIA----------------LPVAILLIVGG---------LVIMLYVFHRKRNNSRL 969

  Fly   902 TVKMTMALSGCEDSEPLRPSNIGA---------NLCKLRIVKDAELRKGGVLGMGAFGRVYKGVW 957
            ...:..|        .:.|....|         .:.:.:|..:.|      ||.|:||.||:|
  Rat   970 GNGVLYA--------SVNPEYFSAADVYVPDEWEVAREKITMNRE------LGQGSFGMVYEG-- 1018

  Fly   958 VPEG---ENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQ-MMLITQL 1018
            |.:|   :..:..||||.:.::.......|||.||.:|......::::||.|....| .::|.:|
  Rat  1019 VAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMEL 1083

  Fly  1019 MPLGCLLDYVRNNRDKIGSKAL----------LNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQT 1073
            |..|.|..|:|:.|.::....|          :..:.:||.||:||...:.|||||||||.:|..
  Rat  1084 MTRGDLKSYLRSLRPEVEQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE 1148

  Fly  1074 PSLVKITDFGLAKLLSSDSNEYKAAGGK--MPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTF 1136
            ...|||.|||:.:.:.  ..:|...|||  :|::|::.|.:::.|||:.||||:|||.:||:.|.
  Rat  1149 DFTVKIGDFGMTRDIY--ETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATL 1211

  Fly  1137 GQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDP 1201
            .::|::.:..:.:...:..|..|::|:.|...::..:..||..:..|||:|.::.....: ..:|
  Rat  1212 AEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKD-EMEP 1275

  Fly  1202 GRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAEPDDY-----LQPKAAPGPSHRTDC 1261
                     .|..:..|.|::.|.               .||::.     |:|          :.
  Rat  1276 ---------SFQEVSFYYSEENKP---------------PEPEELEMELELEP----------EN 1306

  Fly  1262 TDEIPKLNRYCKDPSNKNSSTGDDETDSSAR-EVGVGNLRLDLPVDE 1307
            .:.:|      .|||..::|....|..|..: |.|.|.|.|....||
  Rat  1307 MESVP------LDPSASSASLPLPERHSGHKAENGPGVLVLRASFDE 1347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032	31/118 (26%)
		Furin-like	253..401	CDD:395614	47/181 (26%)
		Recep_L_domain	419..547	CDD:460032	31/137 (23%)
		GF_recep_IV	572..684	CDD:464344	22/138 (16%)
		FU	662..716	CDD:214589	13/88 (15%)
		GF_recep_IV	740..>834	CDD:464344	31/254 (12%)
		PTKc_EGFR_like	930..1208	CDD:270648	89/293 (30%)
Igf1r	XP_008757722.1	Recep_L_domain	51..161	CDD:460032	31/115 (27%)
		Furin-like	175..330	CDD:395614	46/179 (26%)
		Recep_L_domain	353..468	CDD:460032	35/160 (22%)
		FN3	494..607	CDD:238020	23/131 (18%)
		FN3	612..>656	CDD:238020	6/43 (14%)
		FN3	837..926	CDD:238020	6/88 (7%)
		PTKc_InsR_like	994..1271	CDD:173625	88/286 (31%)