DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and Kdr

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_037194.2 Gene:Kdr / 25589 RGDID:2965 Length:1343 Species:Rattus norvegicus


Alignment Length:1466 Identity:295/1466 - (20%)
Similarity:480/1466 - (32%) Gaps:493/1466 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 CIGTK-SRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISH 165
            |:.|: :.:.:|.:..|..:....:.......:..|::|.....:||..:.:..|:....:|::.
  Rat    14 CVETRAASVGLPGDSLHPPKLSTQKDILTILANTTLQITCRGQRDLDWLWPNTPRDSEERVLVTE 78

  Fly   166 -----------------------------VDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYS 201
                                         .||..:|:..:|  ..|:.|..||.:|...:::|.:
  Rat    79 CGDSIFCKTLTVPRVVGNDTGAYKCFYRDTDVSSIVYVYVQ--DHRSPFIASVSDEHGIVYITEN 141

  Fly   202 KMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSE--IVSNGTDAYYNYD--FTAPERECPKCH 262
            |..|:.||....:.|      .|.:||    .::.|  .|.:|....::.:  ||.|....    
  Rat   142 KNKTVVIPCRGSISN------LNVSLC----ARYPEKRFVPDGNRISWDSEKGFTIPSYMI---- 192

  Fly   263 ESCTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYG---PKPRECCHLFCAG-----GCTGPTQKDC 319
             |.....:.|...|.:.:..:.......|.|.|.   ..|.|.  ...||     .||..|:   
  Rat   193 -SYAGMVFCEAKINDETYQSIMYIVLVVGYRIYDVVLSPPHEI--ELSAGEKLVLNCTARTE--- 251

  Fly   320 IACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQD 384
                  .:.|:......|..|:.....|   |.:         ||..||.:.:...:.:......
  Rat   252 ------LNVGLDFSWQFPSSKHQHKKIV---NRD---------VKSLPGTVAKMFLSTLTIDSVT 298

  Fly   385 KMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTF----SGFQDVYANYT 445
            |.|:|          ..||...:.|......:|         :|:..:.|    ||.:.: ...|
  Rat   299 KSDQG----------EYTCTAYSGLMTKKNKTF---------VRVHTKPFIAFGSGMKSL-VEAT 343

  Fly   446 MGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKS 510
            :|              |.|:....||:....     ::.::||     ||.: ||.:.  .||..
  Rat   344 VG--------------SQVRIPVKYLSYPAP-----DIKWYRN-----GRPI-ESNYT--MIVGD 381

  Fly   511 SLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSD 575
            .|..:|:.. :...:.:|::.:            |...::....|.:..|:...:.||......|
  Rat   382 ELTIMEVSE-RDAGNYTVILTN------------PISMEKQSHMVSLVVNVPPQIGEKALISPMD 433

  Fly   576 QCNEDGCWGAGTDQCLTCKNFNFNGTCIAD---------------CGY---ISNAYKFDNRTCKI 622
            .      :..||.|.|||       |..|:               |.|   .:|.|     ||| 
  Rat   434 S------YQYGTMQTLTC-------TVYANPPLHHIQWYWQLEEACSYRPSQTNPY-----TCK- 479

  Fly   623 CHPECRTCNGAGADHCQECVHVRD--GQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIG 685
                             |..||:|  |.:.: |..||:|          |..:|......|:.|.
  Rat   480 -----------------EWRHVKDFQGGNKI-EVTKNQY----------ALIEGKNKTVSTLVIQ 516

  Fly   686 ACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNY 750
            |.        |..|..|                                         ||.....
  Rat   517 AA--------NVSALYK-----------------------------------------CEAINKA 532

  Fly   751 GYHEQVCS------------KCTHYKRREQCETECPADHYTDEE------QRECFQCH------P 791
            |..|:|.|            ..|....:|.....|.||..|.|.      ..:....|      |
  Rat   533 GRGERVISFHVIRGPEITVQPATQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTP 597

  Fly   792 EC---------NGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSK--------------C 833
            .|         ||.....:.:......|:.....:.|.||.|.....|.|              .
  Rat   598 VCKNLDALWKLNGTVFSNSTNDILIVAFQNASLQDQGNYVCSAQDKKTKKRHCLVKQLVILERMA 662

  Fly   834 PLEMRHVNYQYTAIGPYCAASPPRSSKIT------------------------ANLDVNMI---- 870
            |:...::..|.|.||.......|.|...|                        .||.:..:    
  Rat   663 PMITGNLENQTTTIGETIEVVCPTSGNPTPLITWFKDNETLVEDSGIVLKDGNRNLTIRRVRKED 727

  Fly   871 --------------------FIITGA---------VLVPTICI-------LCVVTYICRQKQKAK 899
                                |||.||         :||.|..|       |.:|....::..:.:
  Rat   728 GGLYTCQACNVLGCARAETLFIIEGAQEKTNLEVIILVGTAVIAMFFWLLLVIVLRTVKRANEGE 792

  Fly   900 KETVKMTMALSGCEDSEPL--RPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYK--GVWVPE 960
            .:|..:::.:.  .|..||  |...:..:..|....:| .|:.|..||.||||:|.:  ...:.:
  Rat   793 LKTGYLSIVMD--PDELPLDERCERLPYDASKWEFPRD-RLKLGKPLGRGAFGQVIEADAFGIDK 854

  Fly   961 GENVKIPVAIKELLKSTGAESSEE--FLREAYIMASV-EHVNLLKLLAVCM--SSQMMLITQLMP 1020
            ....| .||:| :||. ||..||.  .:.|..|:..: .|:|::.||..|.  ...:|:|.:...
  Rat   855 TATCK-TVAVK-MLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCK 916

  Fly  1021 LGCLLDYVRNNR-----------------DKIGS------------------------------- 1037
            .|.|..|:|..|                 |.:|.                               
  Rat   917 FGNLSTYLRGKRNEFVPYKSKGARFRSGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSD 981

  Fly  1038 -----------------KALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLA 1085
                             :.|:.:|.|:||||.:|..::.:||||||||:|:...::|||.|||||
  Rat   982 VEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 1046

  Fly  1086 KLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPA-KDI 1149
            :.:..|.:..:....::|:||:|.|.|.:||:|.:||||:|||.:||:.:.|..|:..:.. ::.
  Rat  1047 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEF 1111

  Fly  1150 PDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTR 1214
            ...::.|.::..|:..:.::|.|:|.|||.|...||.|.:|.......                 
  Rat  1112 CRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPAFSELVEHLGNL----------------- 1159

  Fly  1215 LPAYTSQDEKDLIRKLAPTTDGSEAIA-EPDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNK 1278
            |.|...||.||.|  :.|.   ||.:: |.|..|....:|     ..|.:|    ...| ||...
  Rat  1160 LQANAQQDGKDYI--VLPM---SETLSMEEDSGLSLPTSP-----VSCMEE----EEVC-DPKFH 1209

  Fly  1279 NSSTGD-----DETDSSAREVGVGNLRLDLPVDEDD 1309
            ..:|..     ..:...:|.|.|.... |:|::|.:
  Rat  1210 YDNTAGISHYLQNSKRKSRPVSVKTFE-DIPLEEPE 1244

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032 25/141 (18%)
Furin-like 253..401 CDD:395614 26/155 (17%)
Recep_L_domain 419..547 CDD:460032 22/131 (17%)
GF_recep_IV 572..684 CDD:464344 28/131 (21%)
FU 662..716 CDD:214589 8/53 (15%)
GF_recep_IV 740..>834 CDD:464344 25/140 (18%)
PTKc_EGFR_like 930..1208 CDD:270648 95/350 (27%)
KdrNP_037194.2 Ig 224..325 CDD:472250 25/142 (18%)
Ig strand B 242..246 CDD:409353 0/3 (0%)
Ig strand C 257..261 CDD:409353 0/3 (0%)
Ig strand E 290..294 CDD:409353 0/3 (0%)
Ig strand F 304..309 CDD:409353 2/4 (50%)
Ig strand G 317..320 CDD:409353 0/2 (0%)
Ig 329..417 CDD:472250 22/128 (17%)
Ig strand B 348..352 CDD:409353 1/3 (33%)
Ig strand C 361..365 CDD:409353 0/3 (0%)
Ig strand E 381..385 CDD:409353 1/3 (33%)
Ig strand F 395..400 CDD:409353 1/4 (25%)
Ig strand G 410..413 CDD:409353 0/2 (0%)
Ig_3 547..640 CDD:464046 16/92 (17%)
I-set 663..740 CDD:400151 10/76 (13%)
Ig strand B 680..684 CDD:409353 0/3 (0%)
Ig strand C 693..697 CDD:409353 0/3 (0%)
Ig strand E 716..720 CDD:409353 2/3 (67%)
Ig strand F 730..735 CDD:409353 0/4 (0%)
VEGFR-2_TMD 755..789 CDD:375470 6/33 (18%)
PTKc_VEGFR2 822..1163 CDD:270681 97/361 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1267..1314
Blue background indicates that the domain is not in the aligned region.

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