DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and Tyro3

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_058788.1 Gene:Tyro3 / 25232 RGDID:3923 Length:880 Species:Rattus norvegicus


Alignment Length:589 Identity:162/589 - (27%)
Similarity:236/589 - (40%) Gaps:134/589 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   795 GCTGPGADDCKSCRNFKLFDANETGP----YVNSTMFNCTSKCP---LEMRHVNYQYTAIGPYC- 851
            |..||          :||....|.|.    .|..|..|.|...|   |.:|.........||:. 
  Rat   343 GPLGP----------YKLSWVQENGTQDELMVEGTTANLTDWDPQKDLVLRVCASNAIGDGPWSQ 397

  Fly   852 -----------AASPP--RSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETV 903
                       ...||  |:|.:...|.| :..:||.|.|  .:.:|          :|.:||| 
  Rat   398 PLVVSSHDHAGRQGPPHSRTSWVPVVLGV-LTALITAAAL--ALILL----------RKRRKET- 448

  Fly   904 KMTMAL-SGCEDSEPL------------RPSNIGANLCKLRI------------VKDAELRKGGV 943
            :...|. |.....||.            ||..|.|.|..|.|            :.:.:...|.:
  Rat   449 RFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRM 513

  Fly   944 LGMGAFGRVYKGVWVPE-GENVKIPVAIKELLKSTGAESS--EEFLREAYIMASVEHVNLLKLLA 1005
            ||.|.||.|.:.....| |..||:.|   ::||:....||  |||||||..|...:|.::.||:.
  Rat   514 LGKGEFGSVREAQLKQEDGSFVKVAV---KMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVG 575

  Fly  1006 VCMSSQM-------MLITQLMPLGCLLDYVRNNRDKIGS-------KALLNWSTQIAKGMSYLEE 1056
            |.:.|:.       |:|...|..|.|..::..:|  ||.       :.|:.:...||.||.||..
  Rat   576 VSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASR--IGENPFNLPLQTLVRFMVDIACGMEYLSS 638

  Fly  1057 KRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKS 1121
            :..:||||||||.::.....|.:.||||::.:.|.....:....|:|:||||||.:.:.::|..|
  Rat   639 RNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHS 703

  Fly  1122 DVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPT 1186
            ||||||||:||::|.||.|:..|...:|.:.:..|.:|:||..|..::|..:..||..|...||:
  Rat   704 DVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLISGNRLKQPPECMEEVYDLMYQCWSADPKQRPS 768

  Fly  1187 FKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAEPDDYLQPKA 1251
            |   |.:..|.....|....:.          ||||         |.....|...:|.:...|:.
  Rat   769 F---TCLRMELENILGHLSVLS----------TSQD---------PLYINIERAGQPAENGSPEL 811

  Fly  1252 APGPSHRTDCTD--------EIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLDLPVDED 1308
            ..|....::..|        .||...||...|.....|.|..|....:            |::|:
  Rat   812 PCGEQSSSEAGDGSGMGAIGGIPSDCRYIFSPGGLAESPGQLEQQPES------------PLNEN 864

  Fly  1309 DYLM 1312
            ..|:
  Rat   865 QRLL 868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032
GF_recep_IV 572..684 CDD:464344
FU 662..716 CDD:214589
GF_recep_IV 740..>834 CDD:464344 11/42 (26%)
PTKc_EGFR_like 930..1208 CDD:270648 101/306 (33%)
Tyro3NP_058788.1 Ig 40..126 CDD:472250
Ig strand B 50..54 CDD:409553
Ig strand C 63..67 CDD:409553
Ig strand E 90..94 CDD:409553
Ig strand F 104..109 CDD:409553
Ig strand G 118..121 CDD:409553
IgI_2_Axl_Tyro3_like 130..209 CDD:409407
Ig strand A 130..133 CDD:409407
Ig strand A' 136..140 CDD:409407
Ig strand B 144..153 CDD:409407
Ig strand C 158..165 CDD:409407
Ig strand C' 167..170 CDD:409407
Ig strand E 174..185 CDD:409407
Ig strand F 188..197 CDD:409407
Ig strand G 201..209 CDD:409407
FN3 215..307 CDD:238020
fn3 315..396 CDD:394996 16/62 (26%)
PTKc_Tyro3 498..781 CDD:270659 98/290 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 804..827 3/22 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 842..864 5/33 (15%)
Blue background indicates that the domain is not in the aligned region.

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