Protein Alignment Egfr and igf1rb

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_694501.1
• Gene: igf1rb / 245702
• ZFINID: ZDB-GENE-020503-2
• Length: 1380
• Species: Danio rerio
• Alignment Length: 1552
• Identity: 339/1552 - (21%)
• Similarity: 534/1552 - (34%)
• Gaps: 561/1552 - (36%)

  Fly    99 GKIC---------IGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLD------- 147
            |:||         ||...||.                 |||.::|.|::..:.::|.:
Zfish    26 GEICGPGIDIGNDIGNFKRLE-----------------NCTVIEGYLQILLIGDKNSNNQEVFRT 73

  Fly   148 LSFLDNIREVTGYIL---ISHVDVKKVVFPKLQIIRGRTLF---SLSVEEEKYALFVTYSKMYTL 206
            ||| ..:..:|.|:|   :|.::....:||.|.:||||.||   :|.:.|        .:.:..:
Zfish    74 LSF-PKLTMITDYLLLFRVSGLESLSTLFPNLAVIRGRNLFYNCALVIFE--------LTSLKDI 129

  Fly   207 EIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYN--YDFTAPERECPK-C------H 262
            .:.:||::..|.:....|..||::.::.||.|:    ||..|  .|.....:||.. |      :
Zfish   130 GLYNLRNITRGAIRIEKNPELCYLDSVDWSLIL----DAELNNFIDGNKQSKECGNVCPGIMEDN 190

  Fly   263 ESCTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGP-TQKDCIACKNFF 326
            ..||. ||..  .:|||    .|  :|....|  ....:|||..|.|.|:.| :.:.|.||:|:.
Zfish   191 SQCTR-CWTS--NHCQK----VC--RCGQRAC--TDSGQCCHPQCLGSCSVPDSDRACAACQNYN 244

  Fly   327 DEGVCKEECPPMRKYNPTTYVLE---------------TNPEGKYAYGATCVKECPGHLLRD--N 374
            .||.|.|:||      |.||..|               .:.:....:...|:.:||....||  :
Zfish   245 HEGRCVEDCP------PGTYKFEGWRCITRDFCSKVHLPDYDRFVIHAGECISDCPPGFTRDESH 303

  Fly   375 GACVRSCPQDKMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQD 439
            |..|...          |..|:|||.|.|....:.......|.:.||||.||:.|
Zfish   304 GVSVSML----------CTACDGPCDKICDEKVIDSVDAAQSLKGCTVIKGNLHI---------- 348

  Fly   440 VYANYTMGPRYIPLDPERLEVF-STVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFA 503
               |...|...    ...||.| ..:|.:|||:.|..:| ...:||:.::|..|||.:|.::.:|
Zfish   349 ---NIRRGTNI----ASELENFLGLIKTVTGYIKIRSSH-TLTSLSFLKSLRYIHGEELWDNTYA 405

  Fly   504 ALAIVKSSLYSL---EMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADL 565
            ..|:....|..|   ...|| .||.|.:..:.|..|| :|.||          |:|....::.:.
Zfish   406 FAALDNQHLQLLWDWSQHNL-TISEGKLYFRLNPKLC-MSEIR----------KMWAKTGIKDNF 458

  Fly   566 CEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTC 630
            .|                          ::|..||. .|.||  :...||             |.
Zfish   459 VE--------------------------RDFRNNGD-RASCG--TKILKF-------------TS 481

  Fly   631 NGAGADHCQ---ECVHVRDGQHCVS------ECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGA 686
            |...::..:   |.....|.:..|:      |.|.....:          .||    :|:.|..:
Zfish   482 NNTRSNQIKLMWESYRPSDSRDLVNFIVYYKEAPFQNITE----------FDG----QDSCGSDS 532

  Fly   687 CTTCNL-----AIINND---ATVKR-----------CLLKDDKCPDGYFWEYVHPQEQGSL---- 728
            ....|:     .|:|..   :|:|.           .|:.:|:..|.   :.:|...|..:
Zfish   533 WDMVNVDLPDEKILNPGVVLSTLKPWTQYAIFVKAVTLIVEDRDRDK---DRLHLGPQSEVVYIR 594

  Fly   729 -KPLA--------------GRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHY 778
             ||.|              .:.|.|...||.....|           |:|..|.:
Zfish   595 TKPSAPSMPVDIRAYANSSSKLVVRWAPPLAPNGNN-----------TYYVLRWK---------- 638

  Fly   779 TDEEQRECFQCHPECN---------GCTGPGADDCKSCRNFKLFDANETGP-YVNSTMFNCTSKC 833
            ...|.||.:| |..|:         ..||             |.|..:|.| |..:...:.|..|
Zfish   639 QQGEDRELYQ-HNYCSKELKIPVRVSATG-------------LTDTEDTKPTYHETGGRDKTPCC 689

  Fly   834 PL-----EMRHV-----------NYQYTAI----------------------------------G 848
            |.     :::.:           |:.:.||                                  |
Zfish   690 PCPKTEEDLKRIEDDIYYRKAFENFLHNAIFTPRPPDRRRRDLFGVANVTSIHTLLAGHWNLTEG 754

  Fly   849 PYCAASPPRSSKITANLDVNMIFI-ITGAVLVPTICILCVVTYIC---------------RQKQK 897
            .:....|||.........|....| |||  |.| ..:..:..:.|               |.|..
Zfish   755 NFSDDEPPRREFSFLERKVKERHIEITG--LQP-FTVYRIDLHACNEEVRHCSAAAFVFSRTKAA 816

  Fly   898 AKKETVKMTMALSGCEDS------EPLRP------------------------------------ 920
            .|.:.:..::...|.|||      ||.:|
Zfish   817 EKADDIPGSVTWEGQEDSVFLKWPEPDKPNGLIMLYEIQYRLGTEPEKHECVSRQHYRKHKGVKL 881

  Fly   921 SNIGANLCKLRI----------------------------------VKDAELRKGGV-------- 943
            ||:|.....:|:                                  :..|.|...|:
Zfish   882 SNLGPGNYSVRVRATSLAGNGSWTEPIAFSVHQLEQSSYDPVMFIAILPALLLIAGLVVFGYTWM 946

  Fly   944 ----------------------------------------------LGMGAFGRVYKGVWVPEG- 961
                                                          ||.|:||.||:|  :.:|
Zfish   947 NKNRNNDRLGNGVLYASVNPEYFSAAEMYVPDEWEVEREKITMCRELGQGSFGMVYEG--IAKGV 1009

  Fly   962 --ENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQ-MMLITQLMPLGC 1023
              :..:..||||.:.:|.......|||.||.:|......::::||.|....| .::|.:||..|.
Zfish  1010 VKDEPETRVAIKTVNESASLHERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGD 1074

  Fly  1024 LLDYVRNNRDKIGS--------KALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKIT 1080
            |..|:|:.|....:        |.::..:.:||.||:||...:.|||||||||.:|.....|||.
Zfish  1075 LKSYLRSLRSVENTSSLPLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIG 1139

  Fly  1081 DFGLAKLLSSDSNEYKAAGGK--MPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHEN 1143
            |||:.:.:.  ..:|...|||  :|::|::.|.:::.|||:.||||:|||.:||:.|..::|::.
Zfish  1140 DFGMTRDIY--ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQG 1202

  Fly  1144 IPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIP 1208
            :..:.:...:..|..|::|:.|...::..:..||..:..|||:|.::.:...| ..:.|
Zfish  1203 MSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE-DLEAG------ 1260

  Fly  1209 GDKFTRLPAYTSQDEKDLIRKLAPTTD--GSEAIA-------EPDDYLQPKAAPGPSHRTDCTDE 1264
               |.....:.|::.|      .|.|:  ..|.:.       ||...||| .||..|....||
Zfish  1261 ---FKETSFFYSEENK------PPDTEELDMENVGTMENVPLEPSSSLQP-LAPSISPPQQCT-- 1313

  Fly  1265 IPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLDLPVDEDDYLMPT-CQPGPN 1320
              ...:.|..||:..||                      |...|.:.:|| ...||:
Zfish  1314 --AAAQSCSTPSSPPSS----------------------PSSTDKHPLPTSAANGPS 1346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032	32/123 (26%)
		Furin-like	253..401	CDD:395614	46/172 (27%)
		Recep_L_domain	419..547	CDD:460032	40/131 (31%)
		GF_recep_IV	572..684	CDD:464344	18/120 (15%)
		FU	662..716	CDD:214589	12/72 (17%)
		GF_recep_IV	740..>834	CDD:464344	20/103 (19%)
		PTKc_EGFR_like	930..1208	CDD:270648	92/379 (24%)
igf1rb	NP_694501.1	Recep_L_domain	47..162	CDD:460032	32/123 (26%)
		Furin-like	176..320	CDD:395614	46/170 (27%)
		Recep_L_domain	338..449	CDD:460032	41/140 (29%)
		FN3	483..595	CDD:238020	19/128 (15%)
		FN3	600..>644	CDD:238020	9/64 (14%)
		FN3	823..910	CDD:238020	11/86 (13%)
		PTKc_InsR_like	980..1255	CDD:173625	86/278 (31%)