Protein Alignment Egfr and igf1ra

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_073784886.1
• Gene: igf1ra / 245701
• ZFINID: ZDB-GENE-020503-1
• Length: 1433
• Species: Danio rerio
• Alignment Length: 1494
• Identity: 337/1494 - (22%)
• Similarity: 556/1494 - (37%)
• Gaps: 475/1494 - (31%)

  Fly    98 KGKIC---IGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWL--PNENLD------LSFL 151
            :|::|   |..::.::       .::.|.    |||.|:|.|::..:  .|.||:      |||
Zfish    57 RGEVCGPHIDIRNDIT-------EFKKLE----NCTVVEGYLQILLIGDKNNNLNQEHFRTLSF- 109

  Fly   152 DNIREVTGYIL---ISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFV-TYSKMYTLEIPDLR 212
            ..:..||.|||   :|.:|...|:||.|.:||||.||      ..|||.: ..:.:..:.:.:||
Zfish   110 PKLTMVTDYILLFRVSGLDSLSVLFPNLNVIRGRNLF------YNYALVIFEMTSLKDIGLYNLR 168

  Fly   213 DVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESC------------ 265
            ::..|.:....|..||::.::.||.::    ||.:| ::.|..::..:|.:.|
Zfish   169 NITRGAIRIEKNPELCYLDSVDWSLLM----DAEFN-NYIAGNKQSKECGDVCPGINEDRPHCIR 228

  Fly   266 -------THGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCT-GPTQKDCIAC 322
                   ::.||..  .:|||    .|..:|....|  ....:|||..|.|.|| ....|.|.||
Zfish   229 TSFNDNYSYRCWTS--NHCQK----VCPKECEKRAC--TDAGQCCHPQCLGSCTEADNDKACAAC 285

  Fly   323 KNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCV--KECPG-HLLRD------NGACV 378
            :::|.|..|.|.||      |.||..|         |..|:  :.|.. ||..:      ||.|:
Zfish   286 QHYFHEDRCVEACP------PDTYKFE---------GWRCITMEMCARVHLPSEVDFVIHNGECM 335

  Fly   379 RSCPQD---KMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDV 440
            ..||..   ...:...|..|:|.|.|.|...|:.......|.:.||||.||::|
Zfish   336 PDCPPGFTRNETQSMFCSACDGLCDKVCESKTIDSVDAAQSLQGCTVIKGNLQI----------- 389

  Fly   441 YANYTMGPRYIPLDPERLEVF-STVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAA 504
              |...|...    ...||.| ..::.:|||:.|:.|| ...:||:.::|..|.|.:|:::.:|.
Zfish   390 --NIRRGNNI----ASELESFMGLIQTVTGYVRIKHTH-TLGSLSFLKSLRYIVGEELVDNTYAF 447

  Fly   505 LAIVKSSLYSL---EMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLC 566
            .|:...:|..|   ...|| .|.:|.:..:.|..|| :|.||          |:|...::|..:.
Zfish   448 HAVDNHNLQYLWDWTQHNL-TIKTGKLYFRFNPKLC-MSEIR----------KMWEKTSVREKMA 500

  Fly   567 EKNGTICSDQCNEDGCWGAGTDQCLTCKN----FNFNGT-------------------CIADCGY 608
            |       |....:|       :..:|::    |..|.|                   .|:...|
Zfish   501 E-------DDVRSNG-------ERASCESYILKFRSNHTQSTRIKLTWERYRPPDYRDLISFIVY 551

  Fly   609 -----ISNAYKFDNRT-C---------------KICHP------------------------ECR 628
                 ..|..:||.:. |               |...|                        |.:
Zfish   552 YKEAPFQNITEFDGQDGCGSNSWNMVDVDLPQEKSIDPGVLLSPLKPWTQYAIFVKAVTLVVEDK 616

  Fly   629 TCNGAGADHCQECVHVR------------------------------------------------ 645
            ...||.:    |.|::|
Zfish   617 HVGGAKS----EVVYIRTNASAPSMPLDARAYANSSSSLMVKWSPPIAPNGNKTFYFLRWQQQAE 677

  Fly   646 DGQ-----HCVSE-----------------------------------CPKNKYNDRGVCRE--- 667
            ||:     :|..|                                   |||.|.:.:....:
Zfish   678 DGELYQHNYCSKELKIPIRISATSLSDMEGETKPTKSDVAGGEKGCCPCPKTKEDLKAEAEDRSY 742

  Fly   668 -------CHATCDGCTGP----KDTIGIGACT-----TCNLAIINNDATVKRCLLKDDKCPDGYF 716
                   .|.:......|    :|.:|:...|     :.|::::.::.|......|:....:|
Zfish   743 RKVFENFLHNSIFTPRPPDRKRRDLMGVANSTLVSGVSRNISVLESNITQPELPEKEYPFSEG-- 805

  Fly   717 WEYVHPQ--EQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYT 779
              .||.:  |..:|:|.   .|.|.....|    ||..|.  ||.......|.:     |||...
Zfish   806 --KVHTEFMEIHNLRPF---TVYRIDIHAC----NYEVHR--CSAAAFVFSRTK-----PADKAD 854

  Fly   780 D---------EEQRECF-------QCHPECNGC---------TGPGAD--DCKSCRNFKLFDANE 817
            |         :|:.|..       ..||  ||.         .|..|:  :|.|.:.:|:....:
Zfish   855 DIPGSVTQERDEKGEGIVLLRWPEPLHP--NGLILMYEIKYRLGTEAEKHECVSRQQYKVLRGAQ 917

  Fly   818 -----TGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAV 877
                 :|.|  |.....||...      |..:|....:....|.|      |.| |..::   |:
Zfish   918 LSNLASGNY--SARVRATSLAG------NGSWTEPVSFYVPPPKR------NYD-NAFYV---AI 964

  Fly   878 LVPTICIL-----CVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAE 937
            ::|.|.:|     .|...|..:|:.:.:....:..|....|...|.          ::.:..:.|
Zfish   965 IIPVIVLLLLLFVIVAVIIVTKKRNSDRIGNGVLYASVNPEYFSPF----------EMYVPDEWE 1019

  Fly   938 LRKGGV-----LGMGAFGRVYKGVWVPEG---ENVKIPVAIKELLKSTGAESSEEFLREAYIMAS 994
            :.:..:     ||.|:||.||:|  :.:|   :..:..||||.:.:|.......|||.||.:|..
Zfish  1020 VAREKITMCRELGQGSFGMVYEG--IAKGVVKDEPETRVAIKTVNESASVRERIEFLNEASVMKE 1082

  Fly   995 VEHVNLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRDK-IGS--------KALLNWSTQIAK 1049
            ....::::||.|....| .::|.:||..|.|..::|:.|.| .||        |.::..:.:||.
Zfish  1083 FNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRSKEQGSSSQSLPPLKKMIQMAGEIAD 1147

  Fly  1050 GMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGK--MPIKWLALECI 1112
            ||:||...:.|||||||||.:|.....|||.|||:.:.:.  ..:|...|||  :|::|::.|.:
Zfish  1148 GMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY--ETDYYRKGGKGLLPVRWMSPESL 1210

  Fly  1113 RNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCW 1177
            ::.|||:.||||:|||.:||:.|..::|::.:..:.:...:..|..|::|:.|...::..:..||
Zfish  1211 KDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCW 1275

  Fly  1178 HLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEK------------------ 1224
            ..:..|||:|.::.....|....|          |..:..:.|::.|
Zfish  1276 QYNPKMRPSFLEIINSIKEELEPP----------FREVSFFYSEENKPPDTEELDMEVENMENVP 1330

  Fly  1225 -DLIRKLAPTTDGSEAI-AEPDDYLQPKAAPGP---SHRTDCTDEIPKLNRYCKDPSNKNSSTG 1283
             |....|||::.|:..| ::....|.|...||.   |.:|..|           .|.:.::|.|
Zfish  1331 LDPASTLAPSSQGNTGIQSQSPQPLSPAQGPGTPLGSAQTPST-----------SPPSSSASPG 1383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032	40/122 (33%)
		Furin-like	253..401	CDD:395614	46/179 (26%)
		Recep_L_domain	419..547	CDD:460032	38/131 (29%)
		GF_recep_IV	572..684	CDD:464344	31/281 (11%)
		FU	662..716	CDD:214589	9/72 (13%)
		GF_recep_IV	740..>834	CDD:464344	27/125 (22%)
		PTKc_EGFR_like	930..1208	CDD:270648	91/297 (31%)
igf1ra	XP_073784886.1	None