Protein Alignment Egfr and Erbb2

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_058699.2
• Gene: Erbb2 / 24337
• RGDID: 2561
• Length: 1259
• Species: Rattus norvegicus
• Alignment Length: 1443
• Identity: 475/1443 - (32%)
• Similarity: 666/1443 - (46%)
• Gaps: 360/1443 - (24%)

  Fly   100 KICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILIS 164
            ::|.||..:|.:|::.|.|...||..|..|..|.||||||::| .|..||||.:|:||.||:||:
  Rat    27 QVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYVP-ANASLSFLQDIQEVQGYMLIA 90

  Fly   165 HVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFV-----------------TYSKMYTLEIPDLR 212
            |..||:|...:|:|:||..||     |:||||.|                 |...:..|::..|.
  Rat    91 HNQVKRVPLQRLRIVRGTQLF-----EDKYALAVLDNRDPQDNVAASTPGRTPEGLRELQLRSLT 150

  Fly   213 DVLNGQVGFHNNYNLCHMRTIQWSEIV-SNGTDAYYNYDFTAPERECPKCHESC-THGCWGEGPK 275
            ::|.|.|....|..||:...:.|.::. .|...|..:.| |...|.||.|..:| .:.||||.|:
  Rat   151 EILKGGVLIRGNPQLCYQDMVLWKDVFRKNNQLAPVDID-TNRSRACPPCAPACKDNHCWGESPE 214

  Fly   276 NCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRK 340
            :||..:...|:..||  ||.|..|.:|||..||.|||||...||:||.:|...|:|:..||.:..
  Rat   215 DCQILTGTICTSGCA--RCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVT 277

  Fly   341 YNPTTYVLETNPEGKYAYGATCVKECP-GHLLRDNGACVRSCPQDKMDKGGE-----CVPCNGPC 399
            ||..|:....||||:|.:||:||..|| .:|..:.|:|...||.:..:...|     |..|:.||
  Rat   278 YNTDTFESMHNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPC 342

  Fly   400 PKTCPGVTVLH--------AGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPE 456
            .:.|.|:.:.|        :.|:..|..|..|.|::..|.::|.|      :.:.|  ..||.||
  Rat   343 ARVCYGLGMEHLRGARAITSDNVQEFDGCKKIFGSLAFLPESFDG------DPSSG--IAPLRPE 399

  Fly   457 RLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLK 521
            :|:||.|::||||||.|.......|:||.|:||..|.||.|.:..: :|.:....::||.:|:|:
  Rat   400 QLQVFETLEEITGYLYISAWPDSLRDLSVFQNLRIIRGRILHDGAY-SLTLQGLGIHSLGLRSLR 463

  Fly   522 QISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAG 586
            ::.||..:|..|..||:|..:.|..:.:.|.|.:..:.|...:.|...|.:|:..|....|||.|
  Rat   464 ELGSGLALIHRNAHLCFVHTVPWDQLFRNPHQALLHSGNRPEEDCGLEGLVCNSLCAHGHCWGPG 528

  Fly   587 TDQCLTCKNFNFNGTCIADCGY---ISNAYKFDNRTCKICHPECR------TCNGAGADHCQECV 642
            ..||:.|.:|.....|:.:|..   :...|..|.| |..|||||:      ||.|:.||.|..|.
  Rat   529 PTQCVNCSHFLRGQECVEECRVWKGLPREYVSDKR-CLPCHPECQPQNSSETCFGSEADQCAACA 592

  Fly   643 HVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLK 707
            |.:|...||:.||                    :|.|
  Rat   593 HYKDSSSCVARCP--------------------SGVK---------------------------- 609

  Fly   708 DDKCPD-GY--FWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQC 769
                || .|  .|:|  |.|:|         :|:.| |:               .|||
  Rat   610 ----PDLSYMPIWKY--PDEEG---------ICQPC-PI---------------NCTH------- 636

  Fly   770 ETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCP 834
                                                ||     .|.:|.|             ||
  Rat   637 ------------------------------------SC-----VDLDERG-------------CP 647

  Fly   835 LEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVT--YICRQKQK 897
            .|.|              |||             :.|||...|.|....||.||.  .|.|::||
  Rat   648 AEQR--------------ASP-------------VTFIIATVVGVLLFLILVVVVGILIKRRRQK 685

  Fly   898 AKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGE 962
            .:|.|  |...|...|..|||.||....|..::||:|:.||||..|||.||||.||||:|:|:||
  Rat   686 IRKYT--MRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGE 748

  Fly   963 NVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDY 1027
            |||||||||.|.::|..::::|.|.|||:||.|....:.:||.:|::|.:.|:|||||.|||||:
  Rat   749 NVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDH 813

  Fly  1028 VRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDS 1092
            ||.:|.::||:.||||..||||||||||:.||||||||||||||::|:.|||||||||:||..|.
  Rat   814 VREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDE 878

  Fly  1093 NEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGL 1157
            .||.|.|||:||||:|||.|..|.||.:||||::|||:|||:|||.:|::.|||::||||:|.|.
  Rat   879 TEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGE 943

  Fly  1158 KLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAI---------PGDKFT 1213
            :|.||.||::|:|..::.||.:|:..||.|::|.:.|:..||||.|::.|         |.|...
  Rat   944 RLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTF 1008

  Fly  1214 RLPAYTSQDEKDLIRKLAPTTDGSEAIAEPDDYLQPKAAPGPS------HRTDCT---------- 1262
            ........|..||:       |..|.:.....:..|...||..      ||:..|
  Rat  1009 YRSLLEDDDMGDLV-------DAEEYLVPQQGFFSPDPTPGTGSTAHRRHRSSSTRSGGGELTLG 1066

  Fly  1263 ----DEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLR---------------------LD 1302
                :|.|.     :.|...:...|.|..|.   ::.:|..:                     |.
  Rat  1067 LEPSEEGPP-----RSPLAPSEGAGSDVFDG---DLAMGVTKGLQSLSPHDLSPLQRYSEDPTLP 1123

  Fly  1303 LPVDEDDYLMP-TCQPGPN--NNNNIN---------------------------NPNQNNMAAVG 1337
            ||.:.|.|:.| .|.|.|.  |.:.:.                           :|.:|.:.
  Rat  1124 LPPETDGYVAPLACSPQPEYVNQSEVQPQPPLTPEGPLPPVRPAGATLERPKTLSPGKNGVV--- 1185

  Fly  1338 VAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPVMGVPGTMEVKVPMPGSEPTSSD 1402
                 .|:.....:|:|||||            :|.:          ||.....|.|...|...:
  Rat  1186 -----KDVFAFGGAVENPEYL------------VPRE----------GTASPPHPSPAFSPAFDN 1223

  Fly  1403 HEYYNDTQRELQP 1415
            ..|::....|..|
  Rat  1224 LYYWDQNSSEQGP 1236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032	47/127 (37%)
		Furin-like	253..401	CDD:395614	62/154 (40%)
		Recep_L_domain	419..547	CDD:460032	45/127 (35%)
		GF_recep_IV	572..684	CDD:464344	36/120 (30%)
		FU	662..716	CDD:214589	5/56 (9%)
		GF_recep_IV	740..>834	CDD:464344	10/93 (11%)
		PTKc_EGFR_like	930..1208	CDD:270648	163/286 (57%)
Erbb2	NP_058699.2	Recep_L_domain	55..177	CDD:460032	47/127 (37%)
		Furin-like	193..342	CDD:395614	60/150 (40%)
		Recep_L_domain	370..486	CDD:460032	44/124 (35%)
		GF_recep_IV	514..647	CDD:464344	55/273 (20%)
		TM_ErbB2	645..688	CDD:213055	21/82 (26%)
		PTKc_HER2	716..994	CDD:270684	162/277 (58%)
		PHA03247	<1037..1219	CDD:223021	37/219 (17%)