Protein Alignment Egfr and Insrr

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_006501514.1
• Gene: Insrr / 23920
• MGIID: 1346037
• Length: 1313
• Species: Mus musculus
• Alignment Length: 1438
• Identity: 326/1438 - (22%)
• Similarity: 508/1438 - (35%)
• Gaps: 477/1438 - (33%)

  Fly   125 RYTNCTYVDGNLELTWL---PNENL-DLSFLDNIREVTGYILISHV---DVKKVVFPKLQIIRGR 182
            |..||:.|:|:|::..:   ..|:. .||| ..:.:||.|:|:..|   :..:.:||.|.:|||.
Mouse    44 RLENCSVVEGHLQILLMFAATGEDFRGLSF-PRLTQVTDYLLLFRVYGLESLRDLFPNLTVIRGT 107

  Fly   183 TLFSLSVEEEKYALFVTYSKMYTLEIPDLRD--------VLNGQVGFHNNYNLCHMRTIQW---- 235
            .||.      .|||.:       .|:|.|||        ||.|.|....|..|||:.||.|
Mouse   108 RLFL------GYALII-------FEMPHLRDVGLPSLGAVLRGAVRVEKNQELCHLSTIDWGLLQ 159

  Fly   236 -----SEIVSN--GTDAYYNYDFTAPERECP----KCHESCT---------HGCWGEGPKNCQKF 280
                 :.||.|  |.:.         ...||    ...|.|:         :.||..  .:|||.
Mouse   160 PAPGTNHIVGNKLGEEC---------ADVCPGVLGAAGEPCSRTTFSGRTDYRCWTS--SHCQKV 213

  Fly   281 SKLTCSPQC-AGGRCYGPKPRECCHLFCAGGCTGPTQ-KDCIACKNFFDEGVCKEECPPMRKYNP 343
            ........| |||        :|||..|.|||:.|.. :.|:||::.:.:|||...|||
Mouse   214 CPCPRGMACTAGG--------DCCHSECLGGCSQPEDPRACVACRHLYFQGVCLRACPP------ 264

  Fly   344 TTYVLETNPEGKYAYGA-TCV--------KECPGHLLR---DNGACVRSCPQDKMDKGGE--CVP 394
                      |.|.|.: .||        :|.||....   ..|:|:..||......|..  |..
Mouse   265 ----------GTYQYESWRCVTAELCAHLREVPGLATTFGIYEGSCLAQCPPGFTRNGSSIFCHK 319

  Fly   395 CNGPCPKTCPGVTVLHAGNIDSFR------NCTVIDGNIRI-LDQTFSGFQDVYANYTMGPRYIP 452
            |.|.|||.|.    :....|||.:      .||.::||:.: |.|.::
Mouse   320 CEGLCPKECK----VGTKTIDSVQATQDLVGCTHVEGNLILNLRQGYN----------------- 363

  Fly   453 LDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEM 517
            |:||.......|:.|||:|.|:.:. ....|.:|:||:.|.|..:::..:        :||.|:.
Mouse   364 LEPELQRNLGLVETITGFLKIKHSF-ALVTLGFFKNLKLIRGDSMVDGNY--------TLYVLDN 419

  Fly   518 RNLKQISS----------GSVVIQHNRDLC--YVSNIRWPAIQKEPEQKVWVNENLRADLCEKNG 570
            :||:|:.|          |.:....|..||  ::..:......:..:.|..:|.....|
Mouse   420 QNLQQLGSWVTAGLTIPVGKIYFAFNPRLCLEHIYQLEEVTGTRGRQSKAEINPRTNGD------ 478

  Fly   571 TICSDQCNEDGCWGAGTDQCLTCKNFNFNGT-------------------CIADCGYISNAYK-- 614
                    ...|      |..|.: |.||.|                   .::...|    ||
Mouse   479 --------RAAC------QTRTLR-FVFNLTEEDRILLRWERYEPLEARDLLSFIVY----YKES 524

  Fly   615 -FDNRTCKICHPECRTCNGAGADHC-------------------------------QECVHVR-- 645
             |.|.|           ...|.|.|                               |..|.||
Mouse   525 PFQNAT-----------EHVGPDACGTQSWNLLDVELPLSRTQEPGVTLAPLKPWTQYAVFVRAI 578

  Fly   646 ------DGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLA-----IINNDA 699
                  |..|..::.|      ....|...|   ..|.|:|.|.....::..|.     :..|..
Mouse   579 TLTTAEDSPHQGAQSP------IVYLRTLPA---APTVPQDVISTSNSSSHLLVRWKPPVQRNGN 634

  Fly   700 TVKRCLLKDDKCPDG--YFWEYVH--------------PQEQGSL--KPLAGRAVCRKCHP---- 742
            .....:|......||  |..:|.|              .:|..:|  :|..|...|:...|
Mouse   635 ITYYLVLWQRLAEDGDLYINDYCHRGLRLPTSSHDTRFDREDPALEAEPEQGCCPCQHSPPGQAL 699

  Fly   743 ---------LCELCTNYGYHEQVCSKC--------------THYKRREQ--------------CE 770
                     ..:...|:.:|.....|.              :...|||.              .|
Mouse   700 PALEAQEVTFQKKFENFLHHAITIPKAPWKVTSINKNPQRDSERHRREAGLLRLGKNNSDFEIQE 764

  Fly   771 TECPAD--------HYTDEEQRECFQC---------------------HPECNGCTGPGADDCKS 806
            .:.|.:        |:| |.:.:...|                     |.|.:|..|..|.....
Mouse   765 DKVPRERAILSGLRHFT-EYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWKAAG 828

  Fly   807 CRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAI-----------GPYCAASPP--RS 858
            ..:..|.......|  |..:.    |..::.|.:..:.|.:           |.:.|..||  .|
Mouse   829 KSSVTLHWLEPPDP--NGLIL----KYEIKYRRLGEEATVLCVSRLRYAKVGGVHLALLPPGNYS 887

  Fly   859 SKITA-NLDVN------MIFIIT-------------------GAVLVPTICILCVVTYICRQKQK 897
            :|:.| :|..|      :.|.||                   |.:|:.|   |..:.:...:|:.
Mouse   888 AKVRATSLAGNGSWTDGVTFYITDLEEEDTGGMRIFLTVTPVGFMLLVT---LAALGFFYSRKRN 949

  Fly   898 AKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGV-----LGMGAFGRVYKGV- 956
            :...|              .:.|....|:  .:.:..:.|:.:..:     ||.|:||.||:|:
Mouse   950 STLYT--------------SVNPEYFSAS--HMYVPDEWEVPREQIAIIRELGQGSFGMVYEGLA 998

  Fly   957 -WVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVE--HV-----------NLLKLLAVC 1007
             .:..||. ..|||:|.:.:...|....|||:||.:|.:.:  ||           :.::||.|.
Mouse   999 RGLEAGEE-STPVALKTVNELASARERVEFLKEASVMKAFKCHHVRQEGLPQRSLSSQVRLLGVV 1062

  Fly  1008 MSSQ-MMLITQLMPLGCLLDYVRNNRDKIGSKA---------LLNWSTQIAKGMSYLEEKRLVHR 1062
            ...| .::|.:||..|.|..::|:.|.:..:..         ::..:.:||.||:||..|:.|||
Mouse  1063 SQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALSDMIQMAGEIADGMAYLAAKKFVHR 1127

  Fly  1063 DLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGK--MPIKWLALECIRNRVFTSKSDVWA 1125
            ||||||.:|.....|||.|||:.:  .....:|...|||  :|::|:|.|.:::.:||:.||||:
Mouse  1128 DLAARNCMVSQDFTVKIGDFGMTR--DVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWS 1190

  Fly  1126 FGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQL 1190
            |||.:||::|..::|::.:..:.:...:..|..||:.|.|.:.:...:..||.....:||||..:
Mouse  1191 FGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELENCPIQLQELMRLCWQHSPRLRPTFVHI 1255

  Fly  1191 TTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAEPD---------DY 1246
            .....:..|...|..:.          |.|.:.:.....|.||.      ||||         ||
Mouse  1256 LDRIQDELRPSFRLCSF----------YYSPECQRGQASLLPTE------AEPDSPPTLNGASDY 1304

  Fly  1247 LQPKAAPG 1254
            ..|...||
Mouse  1305 SAPNGGPG 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032	41/134 (31%)
		Furin-like	253..401	CDD:395614	47/176 (27%)
		Recep_L_domain	419..547	CDD:460032	32/140 (23%)
		GF_recep_IV	572..684	CDD:464344	29/172 (17%)
		FU	662..716	CDD:214589	11/60 (18%)
		GF_recep_IV	740..>834	CDD:464344	22/163 (13%)
		PTKc_EGFR_like	930..1208	CDD:270648	92/309 (30%)
Insrr	XP_006501514.1	Recep_L_domain	47..158	CDD:460032	41/124 (33%)
		Furin-like	173..326	CDD:395614	48/187 (26%)
		Recep_L_domain	346..461	CDD:460032	32/140 (23%)
		FN3	494..600	CDD:238020	17/126 (13%)
		FN3	605..>649	CDD:238020	7/43 (16%)
		FN3	819..908	CDD:238020	17/94 (18%)
		PTKc_InsR_like	972..1261	CDD:173625	90/291 (31%)