DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and FLT3

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_004110.2 Gene:FLT3 / 2322 HGNCID:3765 Length:993 Species:Homo sapiens


Alignment Length:941 Identity:210/941 - (22%)
Similarity:337/941 - (35%) Gaps:296/941 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   490 ETIHGRQLM--------ESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPA 546
            ||..|..|:        .::...::|..:.||:|.....:::.:...::      |...::..|.
Human   135 ETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALV------CISESVPEPI 193

  Fly   547 IQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIA------D 605
            ::       ||       ||:..|    :.|.|:.......::.:..:.|..:..|.|      :
Human   194 VE-------WV-------LCDSQG----ESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE 240

  Fly   606 CGYISNAYKFD-NRT-------------------CKICHPECRTCNGAGADHCQECVHVRDGQHC 650
            |   :..:..| |:|                   ||..|..    :|.|.....|...:.:|.:.
Human   241 C---TRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVN----HGFGLTWELENKALEEGNYF 298

  Fly   651 -VSECPKNK--------------YNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIIN--ND 698
             :|....|:              .||.|     :.||.....|..:   ...|......||  |.
Human   299 EMSTYSTNRTMIRILFAFVSSVARNDTG-----YYTCSSSKHPSQS---ALVTIVEKGFINATNS 355

  Fly   699 ATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVC-----RKCHPLCELCTNYGYHEQVCS 758
            :........::.|....|..|  ||.:           |     ||..|..:...:.||  .:..
Human   356 SEDYEIDQYEEFCFSVRFKAY--PQIR-----------CTWTFSRKSFPCEQKGLDNGY--SISK 405

  Fly   759 KCTH-------------------------YKRREQCETECPADHYTDEEQRECF----------- 787
            .|.|                         .:|:.|...|..|      .|..||           
Human   406 FCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASA------SQASCFSDGYPLPSWTW 464

  Fly   788 -QCHPECNGCT---GPGADDCKSCRNFKLFDANETGPYVNSTMFNCTS-------KCPLEMRHVN 841
             :|..:...||   ..|..:.|:  |.|:|     |.:|:|:..|.:.       ||        
Human   465 KKCSDKSPNCTEEITEGVWNRKA--NRKVF-----GQWVSSSTLNMSEAIKGFLVKC-------- 514

  Fly   842 YQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVT---YIC-RQKQKAKKET 902
            ..|.::|..|......|......:..|:.|..|..|     |:|.:|.   .|| :.|::.:.|:
Human   515 CAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGV-----CLLFIVVLTLLICHKYKKQFRYES 574

  Fly   903 VKMTMALSGCEDSE----PLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYK----GVWVP 959
            ....:.::|..|:|    ..|.....   .|....:: .|..|.|||.||||:|..    |:   
Human   575 QLQMVQVTGSSDNEYFYVDFREYEYD---LKWEFPRE-NLEFGKVLGSGAFGKVMNATAYGI--- 632

  Fly   960 EGENVKIPVAIKELLKSTGAESSEEFLREAYIMASV-EHVNLLKLLAVC-MSSQMMLITQLMPLG 1022
            ....|.|.||:|.|.:...:...|..:.|..:|..: .|.|::.||..| :|..:.||.:....|
Human   633 SKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYG 697

  Fly  1023 CLLDYVRNNRDKI----------------------------GSKA-------------------- 1039
            .||:|:|:.|:|.                            ||:.                    
Human   698 DLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHS 762

  Fly  1040 -------------------------LLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKI 1079
                                     ||.::.|:||||.:||.|..||||||||||||....:|||
Human   763 EDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKI 827

  Fly  1080 TDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENI 1144
            .|||||:.:.||||.......::|:||:|.|.:...::|.|||||::|:.:||:.:.|..|:..|
Human   828 CDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGI 892

  Fly  1145 PA-KDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVF---------AEFAR 1199
            |. .:...||:.|.|::||...:.:||..:.|||..|:..||:|..||:..         |.:..
Human   893 PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQN 957

  Fly  1200 DPGRYLAIPGDKFTRLPAYTSQDEKDLIRKL 1230
            ..||....|         :|.|:.:...|::
Human   958 VDGRVSECP---------HTYQNRRPFSREM 979

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032 10/64 (16%)
GF_recep_IV 572..684 CDD:464344 24/152 (16%)
FU 662..716 CDD:214589 9/55 (16%)
GF_recep_IV 740..>834 CDD:464344 25/140 (18%)
PTKc_EGFR_like 930..1208 CDD:270648 109/366 (30%)
FLT3NP_004110.2 ig 256..345 CDD:395002 16/100 (16%)
Ig strand B 268..272 CDD:409448 0/3 (0%)
Ig strand C 282..286 CDD:409448 1/3 (33%)
Ig strand E 314..317 CDD:409448 0/2 (0%)
Ig strand F 327..332 CDD:409448 2/4 (50%)
Ig strand G 340..343 CDD:409448 0/2 (0%)
Protein Kinases, catalytic domain 572..947 CDD:473864 112/381 (29%)
Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand 591..597 1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

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