DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and FLT1

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_002010.2 Gene:FLT1 / 2321 HGNCID:3763 Length:1338 Species:Homo sapiens


Alignment Length:1372 Identity:270/1372 - (19%)
Similarity:439/1372 - (31%) Gaps:480/1372 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   270 WGEGPKNCQKFSKLTCSPQCAGGRCYGP-----------KPRECCHLFCAGGCTGPTQKDCIACK 323
            |..|...|...|.|..:...:|.:...|           :..:..||.|.|..........:..|
Human     5 WDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSK 69

  Fly   324 NFFDEGVCKEECPPMRKYNPTTYVLET---NPEGKYAYGATCV-----KECPGHL---LRDNG-- 375
            ......:.|..|....|...:|..|.|   |..|.|:.....|     ||....:   :.|.|  
Human    70 ESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRP 134

  Fly   376 --ACVRSCPQ-DKMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGF 437
              ......|: ..|.:|.|.|.   ||..|.|.:||    .:..|...|:|....||:..:..||
Human   135 FVEMYSEIPEIIHMTEGRELVI---PCRVTSPNITV----TLKKFPLDTLIPDGKRIIWDSRKGF 192

  Fly   438 QDVYANYTMGPRYIPLDPERLEVFSTVKEI---------------TGYLNIEGTHPQFR-----N 482
              :.:|                  :|.|||               |.||    ||.|..     .
Human   193 --IISN------------------ATYKEIGLLTCEATVNGHLYKTNYL----THRQTNTIIDVQ 233

  Fly   483 LSYFRNLETIHGRQLM----------------------------------------ESMFAALAI 507
            :|..|.::.:.|..|:                                        ...::.|.|
Human   234 ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTI 298

  Fly   508 VK-----SSLYSLEMR---NLKQISS-------GSVVIQHNRD---------LCYVSNIRWPAIQ 548
            .|     ..||:..:|   :.|.:::       ..:.::|.:.         ..|..:::..|. 
Human   299 DKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAF- 362

  Fly   549 KEPEQKVWVNENLRADLCEKN--------GTICSDQCNED------------------------- 580
            ..|| .||:.:.|.|  .||:        ..|..|...||                         
Human   363 PSPE-VVWLKDGLPA--TEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIV 424

  Fly   581 -----------------GCWGAGTDQCLTCKNFNFNGTCI-------------ADCGYISN---- 611
                             ..:..|:.|.|||..:......|             |.|.:.||    
Human   425 NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEES 489

  Fly   612 ---------AYKFDNRTCKICHPE---------------------CRTCNGAGADHCQECVHVRD 646
                     ..:.::.|.::...|                     |...|..|........::.|
Human   490 FILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITD 554

  Fly   647 ---------------GQHCVSECPKNKYNDRGVC---------RECHATCDGCTGPKDTIGIGAC 687
                           |:.....|..||:..|.|.         |..|.:   .:..|..|.....
Human   555 VPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYS---ISKQKMAITKEHS 616

  Fly   688 TTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGY 752
            .|.||.|:|                       |..|:.|:.       .||        ..|...
Human   617 ITLNLTIMN-----------------------VSLQDSGTY-------ACR--------ARNVYT 643

  Fly   753 HEQVCSKCTHYKRREQCETECP------ADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFK 811
            .|::..| .....|:|   |.|      :||...........||  .||...|.....|:  |.|
Human   644 GEEILQK-KEITIRDQ---EAPYLLRNLSDHTVAISSSTTLDCH--ANGVPEPQITWFKN--NHK 700

  Fly   812 LFDANETGPYV---NSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSS-KITANLDV----- 867
            :  ..|.|..:   :||:|         :..|..:...: .:|.|:..:.| :.:|.|.|     
Human   701 I--QQEPGIILGPGSSTLF---------IERVTEEDEGV-YHCKATNQKGSVESSAYLTVQGTSD 753

  Fly   868 --NMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKL 930
              |:..|......|.......::|...|:.:::..|.....:::....|..||...      |: 
Human   754 KSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSEIKTDYLSIIMDPDEVPLDEQ------CE- 811

  Fly   931 RIVKDA--------ELRKGGVLGMGAFGRVYK----GVWVPEGENVKIP----VAIKELLKSTGA 979
            |:..||        .|:.|..||.||||:|.:    |:       .|.|    ||:|.|.:...|
Human   812 RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGI-------KKSPTCRTVAVKMLKEGATA 869

  Fly   980 ESSEEFLREAYIMASV-EHVNLLKLLAVC--MSSQMMLITQLMPLGCLLDYVRNNRD-------- 1033
            ...:..:.|..|:..: .|:|::.||..|  ....:|:|.:....|.|.:|:::.||        
Human   870 SEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDA 934

  Fly  1034 ----------------------------------------------------------KIGSKAL 1040
                                                                      .|..:.|
Human   935 ALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDL 999

  Fly  1041 LNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIK 1105
            :::|.|:|:||.:|..::.:||||||||:|:...::|||.|||||:.:..:.:..:....::|:|
Human  1000 ISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLK 1064

  Fly  1106 WLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPA-KDIPDLIEVGLKLEQPEICSLDI 1169
            |:|.|.|.::::::|||||::||.:||:.:.|..|:..:.. :|....:..|:::..||..:.:|
Human  1065 WMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEI 1129

  Fly  1170 YCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTT 1234
            |..:|.|||.|...||.|.:|.....:.                 |.|...||.||.|...|..|
Human  1130 YQIMLDCWHRDPKERPRFAELVEKLGDL-----------------LQANVQQDGKDYIPINAILT 1177

  Fly  1235 DGS----EAIAEPDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPS------------NKNSSTG 1283
            ..|    ...|..:|:.: ::...|...:..:|::..:|.: |..|            |..|...
Human  1178 GNSGFTYSTPAFSEDFFK-ESISAPKFNSGSSDDVRYVNAF-KFMSLERIKTFEELLPNATSMFD 1240

  Fly  1284 DDETDSS 1290
            |.:.|||
Human  1241 DYQGDSS 1247

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614 33/157 (21%)
Recep_L_domain 419..547 CDD:460032 30/211 (14%)
GF_recep_IV 572..684 CDD:464344 30/224 (13%)
FU 662..716 CDD:214589 11/62 (18%)
GF_recep_IV 740..>834 CDD:464344 22/102 (22%)
PTKc_EGFR_like 930..1208 CDD:270648 91/363 (25%)
FLT1NP_002010.2 IG_like 143..219 CDD:214653 23/102 (23%)
IgI_VEGFR 230..330 CDD:409448 11/99 (11%)
Ig strand A 230..234 CDD:409448 0/3 (0%)
Ig strand A' 240..244 CDD:409448 0/3 (0%)
Ig strand B 246..255 CDD:409448 1/8 (13%)
Ig strand C 262..267 CDD:409448 0/4 (0%)
Ig strand C' 270..272 CDD:409448 0/1 (0%)
Ig strand D 275..283 CDD:409448 0/7 (0%)
Ig strand E 290..298 CDD:409448 1/7 (14%)
Ig strand F 308..314 CDD:409448 2/5 (40%)
Ig strand G 319..325 CDD:409448 1/5 (20%)
IgI_VEGFR-1 333..424 CDD:409499 15/94 (16%)
Ig strand A 333..337 CDD:409499 0/3 (0%)
Ig strand A' 343..348 CDD:409499 0/4 (0%)
Ig strand B 353..361 CDD:409499 1/7 (14%)
Ig strand C 365..371 CDD:409499 4/6 (67%)
Ig strand C' 373..376 CDD:409499 1/2 (50%)
Ig strand D 382..386 CDD:409499 0/3 (0%)
Ig strand E 388..393 CDD:409499 1/4 (25%)
Ig strand F 401..410 CDD:409499 0/8 (0%)
Ig strand G 413..424 CDD:409499 0/10 (0%)
Ig_3 427..539 CDD:464046 13/111 (12%)
IG_like 568..640 CDD:214653 20/112 (18%)
Ig strand B 573..577 CDD:409353 0/3 (0%)
Ig strand C 586..594 CDD:409353 1/7 (14%)
Ig strand E 619..623 CDD:409353 2/3 (67%)
Ig strand F 633..638 CDD:409353 2/19 (11%)
I-set 661..748 CDD:400151 22/102 (22%)
Ig strand B 679..682 CDD:409353 0/2 (0%)
Ig strand C 691..695 CDD:409353 0/3 (0%)
Ig strand E 714..718 CDD:409353 3/12 (25%)
Ig strand F 728..733 CDD:409353 1/5 (20%)
PTKc_VEGFR1 819..1157 CDD:271109 88/344 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 940..982 0/41 (0%)
Blue background indicates that the domain is not in the aligned region.

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