DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egfr and Fras1

DIOPT Version :9

Sequence 1:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_780682.3	Gene:	Fras1 / 231470	MGIID:	2385368	Length:	4010	Species:	Mus musculus

Alignment Length:	859	Identity:	196/859 - (22%)
Similarity:	282/859 - (32%)	Gaps:	332/859 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 APERECPKC--------------HE-------------SCTHG---CWGE-------GPKNCQKF 280
            ||.:.||:|              ||             |||||   |..:       ||:..:..
Mouse    78 APNQCCPQCAPRTPGSCHHEGKIHEHGTEWASAPCTVCSCTHGEVRCSHQQCTPLSCGPQELEFL 142

  Fly   281 SKLTCSPQCAG--------------------------------GRCYGPK--------------- 298
            ::..|.|.|.|                                .:|:..:
Mouse   143 AEGRCCPICVGTGKPCSYDGHVFQDGEDWQLSRCAKCVCRNGLTQCFAAQCQPLFCNQDEIVVRV 207

  Fly   299 PRECCHLFCAGGCT--------GPTQKD--CIACKNFFDEGV--C-KEECPPMRKYNPTTYVLET 350
            |.:||....|..|:        |...|:  |..|  ..|:|.  | |:.|||:|.         .
Mouse   208 PGKCCSQCSARSCSTAGQVYEHGEQWKEDACTLC--MCDQGQVRCHKQVCPPLRC---------A 261

  Fly   351 NPEGKYAYGATCVKEC--PGHLLRDNGACVRSCP-------QDKMDKGGECVPC----------N 396
            ..:|:..:...|.:||  |.          |||.       ||:|.||..|..|          .
Mouse   262 KGQGRARHHGQCCEECATPD----------RSCSSGGVLRYQDEMWKGSACEFCMCDQGQVTCQT 316

  Fly   397 GPCPK-TCP-GVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANY-----TMGP-----R 449
            |.|.| .|. |..::|            ::|  :...:..|  ::.|..|     ||..     :
Mouse   317 GECAKVACALGEELVH------------LEG--KCCPECIS--RNGYCIYEQKAETMSSSAREIK 365

  Fly   450 YIPLDPERLE------VFSTVKEITGY-------------LNIEG----------THPQFRNLSY 485
            ::| |.|:.|      ......::|.|             |.::|          .||.....|:
Mouse   366 HVP-DGEKWEEGPCKLCECREAQVTCYEPSCPPCPVATLALVVKGQCCPDCTPVHCHPDCLTCSH 429

  Fly   486 --------------FRNLETIHGRQLMESMFAALAIV--------------KSSLYSLEMRNLKQ 522
                          .:|...:|...|......:|.:.              .|.|..|.|:..:.
Mouse   430 SPDHCDLCQDPTKLLQNGRCVHSCGLGFYQAGSLCLACQPQCSTCTNGLECSSCLPPLLMQQGQC 494

  Fly   523 ISS---GSVVIQHNRDLCYVSNIR-WPAIQK------EPEQKVWVNENLRADLCE---------K 568
            :|:   |.....|:..:|:.|... |...:|      :|.|.      ||...||         :
Mouse   495 VSTCGDGFYQDHHSCAVCHESCAGCWGPTEKHCMACRDPLQV------LRDSSCENTCGNGFYNR 553

  Fly   569 NGT--ICSDQCNEDGCWGAGTDQCLTC--KNFNFNGTCIADC--GYISNAYKFDNRTCKICHPEC 627
            .||  .|...|.  .| |..:.:||:|  |....:|.||::|  ||    |.....:||:||..|
Mouse   554 QGTCVACDQSCK--SC-GPSSPRCLSCAEKTILHDGKCISECPHGY----YADSTGSCKVCHSSC 611

  Fly   628 RTCNGAGADHCQECVH---VRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTT 689
            .:|:|..|.||..|:|   :|.| ||:..|.:..|.|.|:|..|||:|..|.||:.:    .||.
Mouse   612 ASCSGPTAAHCIACIHPQTLRQG-HCLPSCGEGFYPDHGICEACHASCHTCVGPQPS----HCTQ 671

  Fly   690 CNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQ----------GSLKPLAGRAVCRKCHPLC 744
            |                   |.|:.......|..|.          |:...|....:|..|||.|
Mouse   672 C-------------------KKPEAGLLVEQHSGENVPYGKCVSRCGTHFYLESTGLCEVCHPSC 717

  Fly   745 ELCTNYGYHEQVCSKC--THYKRREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKSC 807
            ..|.....|.  |:.|  ||......|.::||..|:..|  ..|.:|||.|..|.||...||.||
Mouse   718 LTCEGKSPHN--CTGCESTHALLAGCCVSQCPETHFNLE--GTCTECHPSCRQCHGPLESDCVSC 778

  Fly   808 RNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFI 872
            .           |::..|..:|.:.|..|      |:..:..|||...|......|||.
Mouse   779 H-----------PHLTLTSGHCKTSCKEE------QFLNLVGYCADCHPLCQHCVANLQ------ 820

  Fly   873 ITGAVLVPTICILC 886
            .||     :||:.|
Mouse   821 DTG-----SICLKC 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	31/198 (16%)
		GF_recep_IV	572..684	CDD:291509	43/118 (36%)
		FU	573..>606	CDD:238021	11/34 (32%)
		FU	617..659	CDD:214589	17/44 (39%)
		FU	662..716	CDD:214589	14/53 (26%)
		FU	739..786	CDD:238021	15/48 (31%)
		FU	784..834	CDD:214589	15/49 (31%)
		PTKc_EGFR_like	930..1208	CDD:270648
		STYKc	938..1194	CDD:214568
		Recep_L_domain	128..239	CDD:279382
		Furin-like	253..401	CDD:279142	54/263 (21%)
		FU	255..292	CDD:214589	17/105 (16%)
		FU	302..345	CDD:238021	16/55 (29%)
Fras1	NP_780682.3	VWC	27..86	CDD:214564	4/7 (57%)
		VWC	94..151	CDD:278520	12/56 (21%)
		VWC	158..215	CDD:278520	4/56 (7%)
		VWC	220..277	CDD:278520	15/67 (22%)
		VWC	284..341	CDD:302663	15/70 (21%)
		VWC	368..415	CDD:302663	8/47 (17%)
		FU 1	408..459		7/50 (14%)
		GF_recep_IV	411..527	CDD:291509	18/115 (16%)
		FU	420..>458	CDD:238021	6/37 (16%)
		FU 2	461..504		7/42 (17%)
		FU	461..503	CDD:214589	7/41 (17%)
		FU 3	506..552		11/51 (22%)
		FU	507..551	CDD:214589	11/49 (22%)
		GF_recep_IV	511..623	CDD:291509	36/124 (29%)
		FU 4	554..598		16/50 (32%)
		FU	555..597	CDD:214589	16/48 (33%)
		FU 5	601..646		17/45 (38%)
		GF_recep_IV	606..728	CDD:291509	42/147 (29%)
		FU	607..652	CDD:238021	18/45 (40%)
		FU 6	648..704		17/78 (22%)
		FU	649..703	CDD:214589	17/76 (22%)
		FU 7	707..752		15/46 (33%)
		FU	707..751	CDD:214589	14/45 (31%)
		FU 8	754..799		19/63 (30%)
		FU	754..798	CDD:214589	18/62 (29%)
		Furin-like	759..912	CDD:279142	29/99 (29%)
		FU 9	802..851		12/39 (31%)
		FU	803..850	CDD:214589	12/38 (32%)
		FU 10	853..899
		FU	853..898	CDD:214589
		FU 11	902..947
		Furin-like	905..1055	CDD:279142
		FU 12	951..996
		FU	951..995	CDD:214589
		FU 13	998..1041
		FU	1004..1048	CDD:238021
		Furin-like_2	1008..1098	CDD:292535
		FU 14	1045..1088
		FU	1045..1086	CDD:214589
		Cadherin_3	<1101..1197	CDD:292802
		CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1101..1196
		Cadherin_3	1167..1309	CDD:292802
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1216..1307
		Cadherin_3	1278..1440	CDD:292802
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1328..1440
		Cadherin_3	1411..1576	CDD:292802
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1465..1561
		Cadherin_3	1531..1693	CDD:292802
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1597..1691
		Cadherin_3	1662..1813	CDD:292802
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1712..1812
		Cadherin_3	1780..1940	CDD:292802
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1834..1938
		Cadherin_3	1906..2061	CDD:292802
		CSPG 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1959..2059
		Cadherin_3	2030..2181	CDD:292802
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2080..2179
		Cadherin_3	2149..2295	CDD:292802
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2201..2293
		Cadherin_3	2263..2408	CDD:292802
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2313..2406
		Cadherin_3	2377..2539	CDD:292802
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2441..2538
		Calx-beta	2555..2648	CDD:295344
Calx-beta	2673..2759	CDD:295344
Calx-beta	2796..2892	CDD:295344
Calx-beta	2918..3009	CDD:295344
Calx-beta	3037..3131	CDD:295344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900