DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and Tyro3

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_062265.2 Gene:Tyro3 / 22174 MGIID:104294 Length:880 Species:Mus musculus


Alignment Length:585 Identity:163/585 - (27%)
Similarity:241/585 - (41%) Gaps:126/585 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   795 GCTGPGADDCKSCRNFKLFDANETGP----YVNSTMFNCTSKCP---LEMRHVNYQYTAIGPYC- 851
            |..||          :||....|.|.    .|..|..|.|...|   |.:|.........||:. 
Mouse   343 GPLGP----------YKLSWVQENGTQDELMVEGTRANLTDWDPQKDLILRVCASNAIGDGPWSQ 397

  Fly   852 -----------AASPP--RSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETV 903
                       ...||  |:|.:...|.| :..:||.|.|  .:.:|          :|.:||| 
Mouse   398 PLVVSSHDHAGRQGPPHSRTSWVPVVLGV-LTALITAAAL--ALILL----------RKRRKET- 448

  Fly   904 KMTMAL-SGCEDSEPL------------RPSNIGANLCKLRI------------VKDAELRKGGV 943
            :...|. |.....||.            ||..|.|.|..|.|            :.:.:...|.:
Mouse   449 RFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRM 513

  Fly   944 LGMGAFGRVYKGVWVPE-GENVKIPVAIKELLKSTGAESS--EEFLREAYIMASVEHVNLLKLLA 1005
            ||.|.||.|.:.....| |..||:.|   ::||:....||  |||||||..|...:|.::.||:.
Mouse   514 LGKGEFGSVREAQLKQEDGSFVKVAV---KMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVG 575

  Fly  1006 VCMSSQM-------MLITQLMPLGCLLDYVRNNRDKIGS-------KALLNWSTQIAKGMSYLEE 1056
            |.:.|:.       |:|...|..|.|..::..:|  ||.       :.|:.:...||.||.||..
Mouse   576 VSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASR--IGENPFNLPLQTLVRFMVDIACGMEYLSS 638

  Fly  1057 KRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKS 1121
            :..:||||||||.::.....|.:.||||::.:.|.....:....|:|:||||||.:.:.::|..|
Mouse   639 RNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHS 703

  Fly  1122 DVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPT 1186
            ||||||||:||::|.||.|:..|...:|.:.:..|.:|:||..|..::|..:..||..|...||:
Mouse   704 DVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPS 768

  Fly  1187 FKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEK--DLIRKLAPTTDGSEAIAEPDDYLQP 1249
            |   |.:..|.....|....:.          ||||..  ::.|...||..||     |:.:...
Mouse   769 F---TCLRMELENILGHLSVLS----------TSQDPLYINIERAEQPTESGS-----PEVHCGE 815

  Fly  1250 KAA--PGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLDLPVDEDDYLM 1312
            :::  .|..........||..:||...|...:.|.|..|....:            |::|:..|:
Mouse   816 RSSSEAGDGSGVGAVGGIPSDSRYIFSPGGLSESPGQLEQQPES------------PLNENQRLL 868

  Fly  1313  1312
            Mouse   869  868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032
GF_recep_IV 572..684 CDD:464344
FU 662..716 CDD:214589
GF_recep_IV 740..>834 CDD:464344 11/42 (26%)
PTKc_EGFR_like 930..1208 CDD:270648 101/306 (33%)
Tyro3NP_062265.2 Ig 40..126 CDD:472250
Ig strand B 50..54 CDD:409553
Ig strand C 63..67 CDD:409553
Ig strand E 90..94 CDD:409553
Ig strand F 104..109 CDD:409553
Ig strand G 118..121 CDD:409553
Ig 130..209 CDD:472250
Ig strand B 146..150 CDD:409407
Ig strand C 160..164 CDD:409407
Ig strand E 178..182 CDD:409407
Ig strand F 190..195 CDD:409407
Ig strand G 204..207 CDD:409407
FN3 215..307 CDD:238020
fn3 315..396 CDD:394996 16/62 (26%)
PTKc_Tyro3 498..781 CDD:270659 98/290 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..864 15/80 (19%)
Blue background indicates that the domain is not in the aligned region.

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