DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egfr and ERBB4

DIOPT Version :9

Sequence 1:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_016859066.1	Gene:	ERBB4 / 2066	HGNCID:	3432	Length:	1349	Species:	Homo sapiens

Alignment Length:	1429	Identity:	506/1429 - (35%)
Similarity:	695/1429 - (48%)	Gaps:	356/1429 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 ICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISH 165
            :|.||:::||..|:.|..||.||..|.||..|.||||:|.: ..|.|||||.::||||||:|::.
Human    28 VCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSI-EHNRDLSFLRSVREVTGYVLVAL 91

  Fly   166 VDVKKVVFPKLQIIRGRTLFSLSVEEEKYAL--FVTYSK-----MYTLEIPDLRDVLNGQVGFHN 223
            ...:.:....|:||||..|:     |::|||  |:.|.|     :..|.:.:|.::|||.|....
Human    92 NQFRYLPLENLRIIRGTKLY-----EDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQ 151

  Fly   224 NYNLCHMRTIQWSEIV------------SNGTDAYYNYDFTAPERECP----------------K 260
            |..||:..||.|.:||            :||:.....:..|  |:..|                :
Human   152 NKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCLAHQDT--EKNNPQLLQSLQPFSLITPGGR 214

  Fly   261 CHESCTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNF 325
            ||:|||..|||....:||..::..|:.|| .||||||...:|||..|||||:||...||.||.||
Human   215 CHKSCTGRCWGPTENHCQTLTRTVCAEQC-DGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNF 278

  Fly   326 FDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKM--DK 388
            .|.|.|..:||....|||||:.||.|...||.|||.|||:||.:.:.|:.:|||:||..||  ::
Human   279 NDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEE 343

  Fly   389 GG--ECVPCNGPCPKTCPGV--------TVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYAN 443
            .|  .|.||...|||.|.|:        ..:.:.|||.|.|||.|:||:..|.....|  |.|..
Human   344 NGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHG--DPYNA 406

  Fly   444 YTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIV 508
            ..      .:|||:|.||.||:||||:|||:...|...:.|.|.||.||.||.|...: :.|.:.
Human   407 IE------AIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGL-SLLILK 464

  Fly   509 KSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTIC 573
            :..:.||:.::||:||:|::.|..|.:|||...|.|..:.....|::.:.:|.:|:.|...|.:|
Human   465 QQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVC 529

  Fly   574 SDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYK-FDNRT-CKICHPECR-------T 629
            :..|:.|||||.|.||||:|:.|:....||..|......:: |:|.: |..|.|:|.       |
Human   530 NHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLT 594

  Fly   630 CNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAI 694
            |:|.|.|:|.:|.|.:||.:||.:||                 ||..|
Human   595 CHGPGPDNCTKCSHFKDGPNCVEKCP-----------------DGLQG----------------- 625

  Fly   695 INNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSK 759
                             .:.:.::|..|.              |:|||
Human   626 -----------------ANSFIFKYADPD--------------RECHP----------------- 642

  Fly   760 CTHYKRREQCETECPADHYTDEEQRECFQCHPEC-NGCTGPGADDCKSCRNFKLFDANETGPYVN 823
                                         |||.| .||.|...:||     ..|.| ...||
Human   643 -----------------------------CHPNCTQGCIGSSIEDC-----IGLMD-RCNGP--- 669

  Fly   824 STMFNCTSKCPLEMRHVNYQYTAIG--PYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILC 886
             |..:|          :.|.:|...  |..|.:|..::.:...|.:.:|..:|.||.|
Human   670 -TSHDC----------IYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYV------- 716

  Fly   887 VVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGR 951
                  |:|...||..::..:.   .|..|||.||....|..:|||:|:.||::..|||.||||.
Human   717 ------RRKSIKKKRALRRFLE---TELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGT 772

  Fly   952 VYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLIT 1016
            ||||:||||||.||||||||.|.::||.:::.||:.||.||||::|.:|::||.||:|..:.|:|
Human   773 VYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVT 837

  Fly  1017 QLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITD 1081
            ||||.||||:||..::|.|||:.||||..||||||.||||:||||||||||||||::|:.|||||
Human   838 QLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITD 902

  Fly  1082 FGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPA 1146
            ||||:||..|..||.|.||||||||:|||||..|.||.:||||::|||||||:|||.:|::.||.
Human   903 FGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPT 967

  Fly  1147 KDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDK 1211
            ::||||:|.|.:|.||.||::|:|..::.||.:||..||.||:|...|:..||||.|||.|.||.
Human   968 REIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDD 1032

  Fly  1212 FTRLPAYTSQ-------DEKDLIRKLAPTTDGSEAIAEPDDYLQPKA--APGP---------SHR 1258
            ..:||:....       ||:||           |.:.:.::||.|:|  .|.|         |:|
Human  1033 RMKLPSPNDSKFFQNLLDEEDL-----------EDMMDAEEYLVPQAFNIPPPIYTSRARIDSNR 1086

  Fly  1259 TDC------------------------------------TDEIPK-------------------- 1267
            ::.                                    |..||:
Human  1087 SEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGT 1151

  Fly  1268 --------------LNRYCKDP---SNKNSSTGDDETDSSAREVGVGNLRLDLPVDEDDYLMPTC 1315
                          ..||..||   :.:.|..|  |.|    |.|......|.|  :.:||.|..
Human  1152 LRKPVAPHVQEDSSTQRYSADPTVFAPERSPRG--ELD----EEGYMTPMRDKP--KQEYLNPVE 1208

  Fly  1316 Q-PGPNNNNN-----INNPNQNNMAAVGVAAGYMDLIGVPVS----VDNPEYLLN-AQTLGVGE 1368
            : |..:...|     ::||..:|.:.           |.|.:    |:.|.||.. |.|||..|
Human  1209 ENPFVSRRKNGDLQALDNPEYHNASN-----------GPPKAEDEYVNEPLYLNTFANTLGKAE 1261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	50/127 (39%)
		GF_recep_IV	572..684	CDD:291509	40/120 (33%)
		FU	573..>606	CDD:238021	16/32 (50%)
		FU	617..659	CDD:214589	19/49 (39%)
		FU	662..716	CDD:214589	3/53 (6%)
		FU	739..786	CDD:238021	3/46 (7%)
		FU	784..834	CDD:214589	15/50 (30%)
		PTKc_EGFR_like	930..1208	CDD:270648	172/277 (62%)
		STYKc	938..1194	CDD:214568	159/255 (62%)
		Recep_L_domain	128..239	CDD:279382	46/117 (39%)
		Furin-like	253..401	CDD:279142	73/167 (44%)
		FU	255..292	CDD:214589	15/52 (29%)
		FU	302..345	CDD:238021	24/42 (57%)
ERBB4	XP_016859066.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	339	1.000	Domainoid score	I1096
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	607	1.000	Inparanoid score	I933
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm40594
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5222
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870