DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egfr and ERBB3

DIOPT Version :9

Sequence 1:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001973.2	Gene:	ERBB3 / 2065	HGNCID:	3431	Length:	1342	Species:	Homo sapiens

Alignment Length:	1448	Identity:	473/1448 - (32%)
Similarity:	662/1448 - (45%)	Gaps:	343/1448 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 ICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISH 165
            :|.||.:.|||..:.|:.|:.|...|..|..|.||||:. |...|.|||||..|||||||:|::.
Human    28 VCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIV-LTGHNADLSFLQWIREVTGYVLVAM 91

  Fly   166 VDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYS-------KMYTLEIPDLRDVLNGQVGFHN 223
            .:...:..|.|:::||..::     :.|:|:||..:       .:..|.:..|.::|:|.|....
Human    92 NEFSTLPLPNLRVVRGTQVY-----DGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEK 151

  Fly   224 NYNLCHMRTIQWSEIV----------SNGTDAYYNYDFTAPERECPKCHESCTHGCWGEGPKNCQ 278
            |..||||.||.|.:||          .||             |.||.|||.|...|||.|.::||
Human   152 NDKLCHMDTIDWRDIVRDRDAEIVVKDNG-------------RSCPPCHEVCKGRCWGPGSEDCQ 203

  Fly   279 KFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNP 343
            ..:|..|:||| .|.|:||.|.:|||..|||||:||...||.||::|.|.|.|...||....||.
Human   204 TLTKTICAPQC-NGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNK 267

  Fly   344 TTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKM--DKGG--ECVPCNGPCPKTCP 404
            .|:.||.||..||.||..||..||.:.:.|..:|||:||.|||  ||.|  .|.||.|.|||.|.
Human   268 LTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACE 332

  Fly   405 GV------TVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIP-LDPERLEVFS 462
            |.      ..:.:.|||.|.|||.|.||:..|....:|  |.:       ..|| ||||:|.||.
Human   333 GTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNG--DPW-------HKIPALDPEKLNVFR 388

  Fly   463 TVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGS 527
            ||:||||||||:...|...|.|.|.||.||.||.|....|:.|.:...::.||..|:||:||:|.
Human   389 TVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGR 453

  Fly   528 VVIQHNRDLCYVSNIRWPAIQKEP-EQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCL 591
            :.|..||.|||..::.|..:.:.| |:::.:..|.....|...|.:|...|:..||||.|..|||
Human   454 IYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCL 518

  Fly   592 TCKNFNFNGTCIADCGYISN-----AYKFDNRTCKICHPECR------TCNGAGADHCQECVHVR 645
            :|:|::..|.|:..|.:::.     |::.:   |..|||||:      ||||:|:|.|.:|.|.|
Human   519 SCRNYSRGGVCVTHCNFLNGEPREFAHEAE---CFSCHPECQPMEGTATCNGSGSDTCAQCAHFR 580

  Fly   646 DGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDK 710
            ||.||||.||                 .|..|.|..|
Human   581 DGPHCVSSCP-----------------HGVLGAKGPI---------------------------- 600

  Fly   711 CPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPA 775
                    |.:|..|..         ||.||   |.||
Human   601 --------YKYPDVQNE---------CRPCH---ENCT--------------------------- 618

  Fly   776 DHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHV 840
                              .||.||...||          ..:|...:..|             |:
Human   619 ------------------QGCKGPELQDC----------LGQTLVLIGKT-------------HL 642

  Fly   841 NYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKM 905
            ....|.|               |.|.|  ||::.|.            |::..:.::.:.:.. |
Human   643 TMALTVI---------------AGLVV--IFMMLGG------------TFLYWRGRRIQNKRA-M 677

  Fly   906 TMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAI 970
            ...|...|..|||.||. .||....||.|:.||||..|||.|.||.|:||||:||||::||||.|
Human   678 RRYLERGESIEPLDPSE-KANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCI 741

  Fly   971 KELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKI 1035
            |.:...:|.:|.:........:.|::|.::::||.:|..|.:.|:||.:|||.|||:||.:|..:
Human   742 KVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGAL 806

  Fly  1036 GSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGG 1100
            |.:.||||..||||||.||||..:|||:|||||||:::||.|::.|||:|.||..|..:...:..
Human   807 GPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEA 871

  Fly  1101 KMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEIC 1165
            |.||||:|||.|....:|.:||||::|||:|||:|||..|:..:...::|||:|.|.:|.||:||
Human   872 KTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQIC 936

  Fly  1166 SLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAI---------PGDK-----FTRLP 1216
            ::|:|..::.||.:|..:|||||:|...|...||||.|||.|         ||.:     ..:|.
Human   937 TIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLE 1001

  Fly  1217 AYTSQDEKDL-------IRKLAPTT---------------DGSEAIAEPDD-YL----------- 1247
            ....:.|.||       ...||.||               .||:::..|.. |:
Human  1002 EVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESC 1066

  Fly  1248 QPKAAPGPS------------------------HRTDCTDEIPKLNRYCKDPSNKNS--STGDDE 1286
            |..|..|.|                        |.|....|:.:....|:..|...|  ..||..
Human  1067 QESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSA 1131

  Fly  1287 TDSSAREVGVGNLRLDLP-VDEDD---YLMPTCQPGPNNNNNINNPNQNNMAAVGVAAGYMDLIG 1347
            ..|....:......|..| ::|:|   |:||     ..:.....:..:..:::||:::    ::|
Human  1132 YHSQRHSLLTPVTPLSPPGLEEEDVNGYVMP-----DTHLKGTPSSREGTLSSVGLSS----VLG 1187

  Fly  1348 VPVSVDNP--EYLLNAQTLGVGESPIPT--QTIGIPVMGVPGTMEVKV---------PMP----- 1394
            .....::.  ||:...:.......|.|:  :.:|...|.|...:...:         |:|
Human  1188 TEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTA 1252

  Fly  1395 GSEPTSSDHEYYNDTQRE 1412
            |:.| ..|:||.| .||:
Human  1253 GTTP-DEDYEYMN-RQRD 1268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	56/128 (44%)
		GF_recep_IV	572..684	CDD:291509	44/122 (36%)
		FU	573..>606	CDD:238021	14/32 (44%)
		FU	617..659	CDD:214589	24/47 (51%)
		FU	662..716	CDD:214589	4/53 (8%)
		FU	739..786	CDD:238021	5/46 (11%)
		FU	784..834	CDD:214589	8/49 (16%)
		PTKc_EGFR_like	930..1208	CDD:270648	137/286 (48%)
		STYKc	938..1194	CDD:214568	124/255 (49%)
		Recep_L_domain	128..239	CDD:279382	42/117 (36%)
		Furin-like	253..401	CDD:279142	75/151 (50%)
		FU	255..292	CDD:214589	18/36 (50%)
		FU	302..345	CDD:238021	22/42 (52%)
ERBB3	NP_001973.2	Recep_L_domain	56..167	CDD:279382	42/116 (36%)
		FU	180..215	CDD:214589	19/48 (40%)
		Furin-like	183..329	CDD:279142	74/146 (51%)
		FU	226..266	CDD:238021	20/39 (51%)
		Recep_L_domain	353..474	CDD:279382	56/129 (43%)
		GF_recep_IV	499..630	CDD:291509	60/253 (24%)
		FU	500..553	CDD:238021	17/55 (31%)
		FU	548..592	CDD:214589	24/63 (38%)
		TM_ErbB3	638..676	CDD:213056	11/79 (14%)
		PTK_HER3	701..979	CDD:173656	136/277 (49%)
		Pkinase_Tyr	709..965	CDD:285015	124/255 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	980..999		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1033..1152		19/118 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6065
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	607	1.000	Inparanoid score	I933
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm40594
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.840