Protein Alignment Egfr and ERBB2

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001369713.1
• Gene: ERBB2 / 2064
• HGNCID: 3430
• Length: 1294
• Species: Homo sapiens
• Alignment Length: 1455
• Identity: 476/1455 - (32%)
• Similarity: 663/1455 - (45%)
• Gaps: 361/1455 - (24%)

  Fly   100 KICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILIS 164
            ::|.||..:|.:|::.|.|...||..|..|..|.||||||:||. |..||||.:|:||.||:||:
Human    24 QVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPT-NASLSFLQDIQEVQGYVLIA 87

  Fly   165 HVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFV----------------TYSKMYTLEIPDLRD 213
            |..|::|...:|:|:||..||     |:.|||.|                :...:..|::..|.:
Human    88 HNQVRQVPLQRLRIVRGTQLF-----EDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTE 147

  Fly   214 VLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHG-CWGEGPKNC 277
            :|.|.|....|..||:..||.|.:|.............|...|.|..|...|... ||||..::|
Human   148 ILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDC 212

  Fly   278 QKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYN 342
            |..::..|:..||  ||.||.|.:|||..||.|||||...||:||.:|...|:|:..||.:..||
Human   213 QSLTRTVCAGGCA--RCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYN 275

  Fly   343 PTTYVLETNPEGKYAYGATCVKECP-GHLLRDNGACVRSCPQDKMDKGGE-----CVPCNGPCPK 401
            ..|:....||||:|.:||:||..|| .:|..|.|:|...||....:...|     |..|:.||.:
Human   276 TDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCAR 340

  Fly   402 TCPGVTVLH--------AGNIDSFRNCTVIDGNIRILDQTFSG----------FQDVYANYTMGP 448
            .|.|:.:.|        :.||..|..|..|.|::..|.::|.|          :.|:.:...:.|
Human   341 VCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGVSLCQQAGVQWYDLGSLQPLPP 405

  Fly   449 RY---------------------IPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETI 492
            .:                     .||.||:|:||.|::||||||.|........:||.|:||:.|
Human   406 GFKQFSCLSLLSSWDYRDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVI 470

  Fly   493 HGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWV 557
            .||.|....: :|.:....:..|.:|:|:::.||..:|.||..||:|..:.|..:.:.|.|.:..
Human   471 RGRILHNGAY-SLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLH 534

  Fly   558 NENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYK--FDNRTC 620
            ..|...|.|...|..|...|....|||.|..||:.|..|.....|:.:|..:....:  .:.|.|
Human   535 TANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHC 599

  Fly   621 KICHPECR------TCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPK 679
            ..|||||:      ||.|..||.|..|.|.:|...||:.||                    :|.|
Human   600 LPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCP--------------------SGVK 644

  Fly   680 DTIGIGACTTCNLAIINNDATVKRCLLKDDKCPD-GY--FWEYVHPQEQGSLKPLAGRAVCRKCH 741
                                            || .|  .|::  |.|:|:         |:.|
Human   645 --------------------------------PDLSYMPIWKF--PDEEGA---------CQPC- 665

  Fly   742 PLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKS 806
            |:               .|||                                           |
Human   666 PI---------------NCTH-------------------------------------------S 672

  Fly   807 CRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIF 871
            |     .|.::.|             ||.|.|              |||..|
Human   673 C-----VDLDDKG-------------CPAEQR--------------ASPLTS------------- 692

  Fly   872 IITGAVLVPTICILCVV--TYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVK 934
            ||:..|.:..:.:|.||  ..|.|::||.:|.|  |...|...|..|||.||....|..::||:|
Human   693 IISAVVGILLVVVLGVVFGILIKRRQQKIRKYT--MRRLLQETELVEPLTPSGAMPNQAQMRILK 755

  Fly   935 DAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVN 999
            :.||||..|||.||||.||||:|:|:|||||||||||.|.::|..::::|.|.|||:||.|....
Human   756 ETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPY 820

  Fly  1000 LLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDL 1064
            :.:||.:|::|.:.|:|||||.|||||:||.||.::||:.||||..||||||||||:.|||||||
Human   821 VSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDL 885

  Fly  1065 AARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVT 1129
            |||||||::|:.|||||||||:||..|..||.|.|||:||||:|||.|..|.||.:||||::|||
Human   886 AARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVT 950

  Fly  1130 IWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVF 1194
            :|||:|||.:|::.|||::||||:|.|.:|.||.||::|:|..::.||.:|:..||.|::|.:.|
Human   951 VWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF 1015

  Fly  1195 AEFARDPGRYLAIPGDKFTRLPA-------YTSQDEKDLIRKLAPTTDGSEAIAEPDDYLQPKAA 1252
            :..||||.|::.|..:...  ||       |.|..|.|   .:....|..|.:.....:..|..|
Human  1016 SRMARDPQRFVVIQNEDLG--PASPLDSTFYRSLLEDD---DMGDLVDAEEYLVPQQGFFCPDPA 1075

  Fly  1253 PGPS------HRTDCT---------------DEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGV 1296
            ||..      ||:..|               :|.|      :.|...:...|.|..|.   ::|:
Human  1076 PGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAP------RSPLAPSEGAGSDVFDG---DLGM 1131

  Fly  1297 GNLR---------------------LDLPVDEDDYLMP-TCQPGPNNNNNIN------NPNQNNM 1333
            |..:                     :.||.:.|.|:.| ||.|.|...|..:      :|.:..:
Human  1132 GAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPL 1196

  Fly  1334 AAVGVAAGYM---------------DLIGVPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPVMGV 1383
            .|...|...:               |:.....:|:|||||    |...|.:|.|.
Human  1197 PAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYL----TPQGGAAPQPH---------- 1247

  Fly  1384 PGTMEVKVPMPGSEPTSSDHEYYND 1408
                    |.|...| :.|:.||.|
Human  1248 --------PPPAFSP-AFDNLYYWD 1263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032	47/126 (37%)
		Furin-like	253..401	CDD:395614	62/154 (40%)
		Recep_L_domain	419..547	CDD:460032	45/158 (28%)
		GF_recep_IV	572..684	CDD:464344	34/119 (29%)
		FU	662..716	CDD:214589	5/56 (9%)
		GF_recep_IV	740..>834	CDD:464344	9/93 (10%)
		PTKc_EGFR_like	930..1208	CDD:270648	163/277 (59%)
ERBB2	NP_001369713.1	Recep_L_domain	52..173	CDD:460032	47/126 (37%)
		Furin-like	189..338	CDD:395614	60/150 (40%)
		Recep_L_domain	433..521	CDD:460032	34/88 (39%)
		GF_recep_IV	550..682	CDD:464344	51/271 (19%)
		TM_ErbB2	680..723	CDD:213055	19/82 (23%)
		PTKc_HER2	751..1029	CDD:270684	163/277 (59%)