Protein Alignment Egfr and EPHB6

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_004436.4
• Gene: EPHB6 / 2051
• HGNCID: 3396
• Length: 1022
• Species: Homo sapiens
• Alignment Length: 736
• Identity: 165/736 - (22%)
• Similarity: 269/736 - (36%)
• Gaps: 185/736 - (25%)

  Fly   600 GTCIADC--------GYISNAYKFDNRTCKICHPECRTCNG-------AGADHCQECVHVRDGQH 649
            |||:|..        |....:            |....|||       .|...||.......|..
Human   261 GTCVAHAEPEEDGVGGQAGGS------------PPRLHCNGEGKWMVAVGGCRCQPGYQPARGDK 313

  Fly   650 CVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTC--NLAIINNDATVKRCLLKDDKCP 712
            ....||:..|                   |.:.|...|:.|  .....|..|.|..||
Human   314 ACQACPRGLY-------------------KASAGNAPCSPCPARSHAPNPAAPVCPCL------- 352

  Fly   713 DGYFWEYVHPQE-----------------QGSL--------KPLAGR------AVCRKCHPLCEL 746
            :|::.....|.|                 |||.        :.|.||      .||::|....|.
Human   353 EGFYRASSDPPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEP 417

  Fly   747 CTNYGYHEQVCSKC---THYKRREQCETE------------------------------------ 772
            .:..|   ..|.:|   .|:..|::..||
Human   418 ASGGG---GTCHRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAA 479

  Fly   773 ------------CPADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFD--ANETGPYVN 823
                        .|..|.............|:.:...|...|     ...:.:|  .:|:..:..
Human   480 INVSTSHEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNILD-----YQLRYYDQAEDESHSFTL 539

  Fly   824 STMFNCTSKCPLEMRHV-NYQYTA-----IGPYCA----ASPPR---SSKITANLDVNMIFIITG 875
            ::..|..:...|...|: .:|..|     .|||..    .:.|:   ||::...|.: :|..|.|
Human   540 TSETNTATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSL-VIGSILG 603

  Fly   876 AVLVPTICILCVVTYICRQKQKAKKETVKMTMALS-GCEDSEPLRPSNIGANLCK-----LRIVK 934
            |:....:..:.|:..:.::|::....|.::....| |......:.||.. .:.|:     .|.|.
Human   604 ALAFLLLAAITVLAVVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTY-EDPCQAIRELAREVD 667

  Fly   935 DAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSE-EFLREAYIMASVEHV 998
            .|.::...|:|.|:||.|.:|...|.|...: .||| :.|.:.||||.: .||..|.::...:|.
Human   668 PAYIKIEEVIGTGSFGEVRQGRLQPRGRREQ-TVAI-QALWAGGAESLQMTFLGRAAVLGQFQHP 730

  Fly   999 NLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHR 1062
            |:|:|..|...|: :|::|:.|.||.|..::|....:..|..|:.....:|..|.||.....|||
Human   731 NILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHR 795

  Fly  1063 DLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFG 1127
            .|:|.:|||.:..:.|:...|           :...|....::|.|.|.|.:...|:.||||:||
Human   796 SLSAHSVLVNSHLVCKVARLG-----------HSPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFG 849

  Fly  1128 VTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTT 1192
            :.:||::::|:||:.::..:::.:.||...:|..|..|...::..:|..|..|.|.||.|.||..
Human   850 ILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVA 914

  Fly  1193 VFAEFARDPGRYLA--IPGDK 1211
            .|.:..|.|....|  .||::
Human   915 AFDKMIRKPDTLQAGGDPGER 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032
		GF_recep_IV	572..684	CDD:464344	17/98 (17%)
		FU	662..716	CDD:214589	10/55 (18%)
		GF_recep_IV	740..>834	CDD:464344	17/146 (12%)
		PTKc_EGFR_like	930..1208	CDD:270648	87/281 (31%)
EPHB6	NP_004436.4	EphR_LBD_B6	33..232	CDD:198443
		Ephrin_rec_like	305..346	CDD:429604	9/59 (15%)
		fn3	372..472	CDD:394996	17/102 (17%)
		fn3	490..572	CDD:394996	13/86 (15%)
		EphA2_TM	613..668	CDD:464211	10/55 (18%)
		Protein Kinases, catalytic domain	666..920	CDD:473864	83/266 (31%)
		SAM_EPH-B6	946..1014	CDD:188954
		PDZ-binding. /evidence=ECO:0000255	1020..1022