Protein Alignment Egfr and EPHB3

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_004434.2
• Gene: EPHB3 / 2049
• HGNCID: 3394
• Length: 998
• Species: Homo sapiens
• Alignment Length: 732
• Identity: 177/732 - (24%)
• Similarity: 276/732 - (37%)
• Gaps: 197/732 - (26%)

  Fly   577 CNEDGCW----GAGT-----------DQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPE 626
            ||.||.|    ||.|           .||..|...::..             |.....|..|.|.
Human   256 CNGDGEWMVPVGACTCATGHEPAAKESQCRPCPPGSYKA-------------KQGEGPCLPCPPN 307

  Fly   627 CRTCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTC- 690
            .||.:.|.:               :..|..|.|         .|..|...        .||||.
Human   308 SRTTSPAAS---------------ICTCHNNFY---------RADSDSAD--------SACTTVP 340

  Fly   691 --NLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYH 753
              ...:|:|.......|            |:..|::.|....|....:|:|||.        ...
Human   341 SPPRGVISNVNETSLIL------------EWSEPRDLGGRDDLLYNVICKKCHG--------AGG 385

  Fly   754 EQVCSKCTH-----------YKRREQCETECPADHYTDEEQRECFQCHPECNGCTG--------- 798
            ...||:|..           .:||...........||.|.|        ..||.:|
Human   386 ASACSRCDDNVEFVPRQLGLTERRVHISHLLAHTRYTFEVQ--------AVNGVSGKSPLPPRYA 442

  Fly   799 --------PGADDCKSCR--------------------------NFKLFDANETGPYVNSTMFNC 829
                    ....:..:.|                          ..|.|:.:|.   :.||:.:.
Human   443 AVNITTNQAAPSEVPTLRLHSSSGSSLTLSWAPPERPNGVILDYEMKYFEKSEG---IASTVTSQ 504

  Fly   830 TSKCPLEMRHVNYQYT------AIGPYCAASPPRSSKITA-------NLDVNMIFII----TGAV 877
            .:...|:....:.:|.      .:..|...|.|...:.|:       .|...:..|:    .|.|
Human   505 MNSVQLDGLRPDARYVVQVRARTVAGYGQYSRPAEFETTSERGSGAQQLQEQLPLIVGSATAGLV 569

  Fly   878 LVPTICILCVVTYICRQKQKAKKE---TVKMTMALS----------GCED-SEPLRPSNIGANLC 928
            .|..:.::.:|   |.:||:...:   |.|:...::          ..|| :|.:|..   |...
Human   570 FVVAVVVIAIV---CLRKQRHGSDSEYTEKLQQYIAPGMKVYIDPFTYEDPNEAVREF---AKEI 628

  Fly   929 KLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMA 993
            .:..||..|     |:|.|.||.|.:|.....|.. ::.||||.|..........:||.||.||.
Human   629 DVSCVKIEE-----VIGAGEFGEVCRGRLKQPGRR-EVFVAIKTLKVGYTERQRRDFLSEASIMG 687

  Fly   994 SVEHVNLLKLLAVCMSSQ-MMLITQLMPLGCLLD-YVRNNRDKIGSKALLNWSTQIAKGMSYLEE 1056
            ..:|.|:::|..|...|: :|::|:.|. .|.|| ::|.|..:.....|:.....||.||.||.|
Human   688 QFDHPNIIRLEGVVTKSRPVMILTEFME-NCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSE 751

  Fly  1057 KRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNE--YKAA-GGKMPIKWLALECIRNRVFT 1118
            ...|||||||||:||.:..:.|::||||::.|..|.::  |.:: |||:||:|.|.|.|..|.||
Human   752 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFT 816

  Fly  1119 SKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAM 1183
            |.||||::|:.:||::::|:||:.::..:|:.:.:|...:|..|..|...::..:|.||..|..:
Human   817 SASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNL 881

  Fly  1184 RPTFKQLTTVFAEFARD 1200
            ||.|.|:.....:..|:
Human   882 RPKFSQIVNTLDKLIRN 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032
		GF_recep_IV	572..684	CDD:464344	23/121 (19%)
		FU	662..716	CDD:214589	9/56 (16%)
		GF_recep_IV	740..>834	CDD:464344	20/147 (14%)
		PTKc_EGFR_like	930..1208	CDD:270648	99/276 (36%)
EPHB3	NP_004434.2	EphR_LBD_B3	39..211	CDD:198446
		Ephrin_rec_like	272..316	CDD:429604	10/56 (18%)
		fn3	341..436	CDD:394996	23/122 (19%)
		FN3	<473..542	CDD:238020	10/71 (14%)
		EphA2_TM	560..630	CDD:464211	15/75 (20%)
		PTKc_EphR_B	628..896	CDD:173638	98/274 (36%)
		SAM_superfamily	922..990	CDD:472832