Protein Alignment Egfr and EPHB2

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001296122.1
• Gene: EPHB2 / 2048
• HGNCID: 3393
• Length: 1055
• Species: Homo sapiens
• Alignment Length: 773
• Identity: 189/773 - (24%)
• Similarity: 295/773 - (38%)
• Gaps: 218/773 - (28%)

  Fly   577 CNEDGCWGAGTDQCLTCKNFNF--NGTCIADCGYISNAYKFD--NRTCKICHPECRTCNGAGADH 637
            ||.||.|.....:|:....|..  |||....|.  |..:|.:  :..|..|....|| ...||.:
Human   241 CNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCP--SGTFKANQGDEACTHCPINSRT-TSEGATN 302

  Fly   638 CQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTT---CNLAIIN--N 697
            |                         |||..:...|  ..|.|.    .|||   ...|:|:  |
Human   303 C-------------------------VCRNGYYRAD--LDPLDM----PCTTIPSAPQAVISSVN 336

  Fly   698 DATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKC-- 760
            :.::              ..|:..|::.|..:.|....:|:.|          |.....|::|
Human   337 ETSL--------------MLEWTPPRDSGGREDLVYNIICKSC----------GSGRGACTRCGD 377

  Fly   761 -THYKRREQCETE--------CPADHYTDEEQRECFQCHPECNGCT--GPGADDCKSCRNFKLFD 814
             ..|..|:...||        .....||.|.|        ..||.|  .|.:....|..    ..
Human   378 NVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQ--------AVNGVTDQSPFSPQFASVN----IT 430

  Fly   815 ANETGPYVNSTMFNCTSK------------------CPLEMRHV-----NYQYTAIGPYCAASPP 856
            .|:..|...|.|...:..                  ...|:::.     .|..|||      ..|
Human   431 TNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAI------KSP 489

  Fly   857 RSSKITANLDVNMIFII-----------------------------------------TGAVLVP 880
            .::.....|....|::.                                         :.|.||.
Human   490 TNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPLIIGSSAAGLVF 554

  Fly   881 TICILCVVTYICRQK--QKAKKE-TVKMTMALSG--------------CED-SEPLRPSNIGANL 927
            .|.:: |:..:|.::  ::|..| |.|:....||              .|| :|.:|......::
Human   555 LIAVV-VIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDI 618

  Fly   928 CKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIP------VAIKELLKSTGAESSEEFL 986
            ..::|.:        |:|.|.||.|..|       ::|:|      ||||.|......:...:||
Human   619 SCVKIEQ--------VIGAGEFGEVCSG-------HLKLPGKREIFVAIKTLKSGYTEKQRRDFL 668

  Fly   987 REAYIMASVEHVNLLKLL-AVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKG 1050
            .||.||...:|.|::.|. .|..|:.:|:||:.|..|.|..::|.|..:.....|:.....||.|
Human   669 SEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAG 733

  Fly  1051 MSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNE--YKAA-GGKMPIKWLALECI 1112
            |.||.:...|||||||||:||.:..:.|::||||::.|..|:::  |.:| |||:||:|.|.|.|
Human   734 MKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAI 798

  Fly  1113 RNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCW 1177
            :.|.|||.||||::|:.:||::::|:||:.::..:|:.:.||...:|..|..|...::..:|.||
Human   799 QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCW 863

  Fly  1178 HLDAAMRPTFKQLTTVFAEFARDPGRYLAIPG----------DKFTRLPAYTSQDEKD 1225
            ..|...||.|.|:.....:..|:|....|:..          |:  .:|.|||.:..|
Human   864 QKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLDR--TIPDYTSFNTVD 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032
		GF_recep_IV	572..684	CDD:464344	26/110 (24%)
		FU	662..716	CDD:214589	12/58 (21%)
		GF_recep_IV	740..>834	CDD:464344	21/124 (17%)
		PTKc_EGFR_like	930..1208	CDD:270648	101/287 (35%)
EPHB2	NP_001296122.1	EphR_LBD_B2	19..196	CDD:198445
		fn3	326..421	CDD:394996	24/126 (19%)
		fn3	437..520	CDD:394996	10/88 (11%)
		EphA2_TM	544..617	CDD:464211	16/73 (22%)
		PTKc_EphR_B	616..884	CDD:173638	98/282 (35%)
		SAM_EPH-B2	910..980	CDD:188951	5/10 (50%)
		PDZ-binding (in isoform 2). /evidence=ECO:0000255	984..986
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	990..1055