DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and EPHA7

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_004431.1 Gene:EPHA7 / 2045 HGNCID:3390 Length:998 Species:Homo sapiens


Alignment Length:1090 Identity:226/1090 - (20%)
Similarity:384/1090 - (35%) Gaps:362/1090 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   410 HAGNIDSFRNCTVIDG-----NIRILDQTFSGFQDVYA---NYTMGPRY---IPLDPER------ 457
            |.|...:.:...::|.     .:..:....:|::::..   |||....|   ..::|.:      
Human    23 HTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRT 87

  Fly   458 ------------LEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIH--GRQLMESMFAALAIV 508
                        :|:..|:::......:.||..:..||.|:   ||.:  ||.:.|:::..:..:
Human    88 NWISKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYY---ETDYDTGRNIRENLYVKIDTI 149

  Fly   509 -------------KSSLYSLEMRNLKQISS----------GSVVIQHNRDLCYVSNIRWPAIQKE 550
                         :....:.|:|.:..:|.          |:.:...:..:.|            
Human   150 AADESFTQGDLGERKMKLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYY------------ 202

  Fly   551 PEQKVW-VNENLR-----------ADLCEKNGTICSD-----------QCNEDGCWGAGTDQCLT 592
              :|.| :.|||.           :.|.|..||..|.           .|:.:|.|....     
Human   203 --KKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPI----- 260

  Fly   593 CKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNGAG----ADHCQECVHVRDGQHCVSE 653
                   |.||...||   ..|.|  ||:.|        |.|    :....:|          |.
Human   261 -------GKCICKAGY---QQKGD--TCEPC--------GRGFYKSSSQDLQC----------SR 295

  Fly   654 CPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACT-----TCNLAIINNDATVKRCLLKDDKCPD 713
            ||.:.::|:.....|.........|.|...: |||     ..||....|..||.           
Human   296 CPTHSFSDKEGSSRCECEDGYYRAPSDPPYV-ACTRPPSAPQNLIFNINQTTVS----------- 348

  Fly   714 GYFWEYVHPQEQGSLKPLAGRAVCRKC---HPLCELC-TNYGYHEQVCSKCTHY----------- 763
               .|:..|.:.|....:..|.:|::|   ...|..| :|.||..|......:|           
Human   349 ---LEWSPPADNGGRNDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHAN 410

  Fly   764 ---------------------------------------------KRREQCETECPADH------ 777
                                                         :|..:...:.| :|      
Human   411 YTFEVEAVNGVSDLSRSQRLFAAVSITTGQAAPSQVSGVMKERVLQRSVELSWQEP-EHPNGVIT 474

  Fly   778 -----YTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNS----TMFNCTSKC 833
                 |.:::|||                      |.:.......|...:|:    |::      
Human   475 EYEIKYYEKDQRE----------------------RTYSTVKTKSTSASINNLKPGTVY------ 511

  Fly   834 PLEMRHVNYQYTAIGPYCAASPPRSSKITANLDV--------------------NMIFIITGAVL 878
            ..::|    .:||.| |...||        .|||                    |.:.||....:
Human   512 VFQIR----AFTAAG-YGNYSP--------RLDVATLEEATGKMFEATAVSSEQNPVIIIAVVAV 563

  Fly   879 VPTICILCVV-TYICRQK----QKAKK---ETVKMTMALSGCE---DSEPLRPSNIGANLCKLRI 932
            ..||.::.:| .:|..::    .||.:   |.:.......|.:   |.|.....|...:    :.
Human   564 AGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFKFPGTKTYIDPETYEDPNRAVH----QF 624

  Fly   933 VKDAE---LRKGGVLGMGAFGRVYKGVWVPEGENVKIP------VAIKELLKSTGAESSEEFLRE 988
            .|:.:   ::...|:|.|.||.|..|       .:|:|      ||||.|......:...:||.|
Human   625 AKELDASCIKIERVIGAGEFGEVCSG-------RLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCE 682

  Fly   989 AYIMASVEHVNLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMS 1052
            |.||...:|.|::.|..|....: :|::.:.|..|.|..::|.:..:.....|:.....||.||.
Human   683 ASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMR 747

  Fly  1053 YLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNE-YKAAGGKMPIKWLALECIRNRV 1116
            ||.:...|||||||||:||.:..:.|::||||::::..|... |...|||:|::|.|.|.|:.|.
Human   748 YLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK 812

  Fly  1117 FTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDA 1181
            |||.||||::|:.:||::::|:||:.::..:|:...||.|.:|..|..|...::..:|.||..:.
Human   813 FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKER 877

  Fly  1182 AMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAEPDDY 1246
            |.||.|:|:..:..:..|:|..         .:.|..|..      |.::|..|.:.        
Human   878 AERPKFEQIVGILDKMIRNPNS---------LKTPLGTCS------RPISPLLDQNT-------- 919

  Fly  1247 LQPKAAPGPSHRTDCTD----EIPKLNRYCKDPSNKNSSTGDDETDSSAR 1292
                    |...|.|:.    :..|:.|| ||   ..::.|.:..:|.||
Human   920 --------PDFTTFCSVGEWLQAIKMERY-KD---NFTAAGYNSLESVAR 957

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032 24/181 (13%)
GF_recep_IV 572..684 CDD:464344 24/126 (19%)
FU 662..716 CDD:214589 11/58 (19%)
GF_recep_IV 740..>834 CDD:464344 19/168 (11%)
PTKc_EGFR_like 930..1208 CDD:270648 94/288 (33%)
EPHA7NP_004431.1 EphR_LBD_A7 30..206 CDD:198453 25/192 (13%)
FN3 <314..>539 CDD:442628 44/281 (16%)
FN3 443..534 CDD:238020 21/132 (16%)
EphA2_TM 565..630 CDD:464211 12/68 (18%)
PTKc_EphR_A 628..894 CDD:270651 91/272 (33%)
SAM_EPH-A7 919..988 CDD:188947 12/59 (20%)
PDZ-binding. /evidence=ECO:0000255 996..998
Blue background indicates that the domain is not in the aligned region.

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