Protein Alignment Egfr and EPHA5

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001268694.1
• Gene: EPHA5 / 2044
• HGNCID: 3389
• Length: 1038
• Species: Homo sapiens
• Alignment Length: 1003
• Identity: 217/1003 - (21%)
• Similarity: 362/1003 - (36%)
• Gaps: 298/1003 - (29%)

  Fly   416 SFRNCTVIDGNIRILDQTFSGF----QDVYANYTMGPRYIPLDP-------------ERLEVFST 463
            :.|:|..:.|.:....:||:.:    .|.........:||.:|.             :|:...:|
Human   133 TLRDCNSLPGGLGTCKETFNMYYFESDDQNGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNT 197

  Fly   464 VKEITGYLNIEGTHPQFRNLS----------YFRNLETIHGRQLMESMFAALAIVKSSLYSLEMR 518
            .....|.|:.:|.:..|:::.          |::.         ..|:...||:...::...:..
Human   198 EVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKK---------CPSVVRHLAVFPDTITGADSS 253

  Fly   519 NLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCW 583
            .|.:: |||.| .|             ::..||.:.                     .|:.:|.|
Human   254 QLLEV-SGSCV-NH-------------SVTDEPPKM---------------------HCSAEGEW 282

  Fly   584 GAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNG--AGADHCQECVHVRD 646
            .....:|: ||                ..|:..|.||::|.|      |  ..:.|.|.|
Human   283 LVPIGKCM-CK----------------AGYEEKNGTCQVCRP------GFFKASPHIQSC----- 319

  Fly   647 GQHCVSECPKNKYNDRGVCRECHATCD-------------GCTGPKDTIGIGACTTCNLAIIN-N 697
                 .:||.:.|........|  .|:             .||.|.        :....||.| |
Human   320 -----GKCPPHSYTHEEASTSC--VCEKDYFRRESDPPTMACTRPP--------SAPRNAISNVN 369

  Fly   698 DATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTH 762
            :.:|              |.|::.|.:.|..|.::....|:||:....:|...|.|.:...:.:.
Human   370 ETSV--------------FLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSG 420

  Fly   763 YKRREQCETECPA-DHYTDEEQRECFQCHPECNGCT--GPGADDC-------------------- 804
            .|.......:..| .:||.|.:        ..||.:  .|||...
Human   421 LKNTSVMMVDLLAHTNYTFEIE--------AVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKK 477

  Fly   805 -KSCRN--------------------FKLFDANETGPYV----NSTMFNCTSKCPLEM------- 837
             |..:|                    .|.|:.::...|.    ..|........|..:
Human   478 GKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPASVYVFQIRA 542

  Fly   838 ----------RHVNYQYTAIGPYCAASPPRSS----KITANLDVNMIFIITGAVLVPTIC----- 883
                      |...::.|.:.  .|||..:|.    .::..:.|.::.::.|.:|..:.|
Human   543 RTAAGYGVFSRRFEFETTPVS--VAASSDQSQIPVIAVSVTVGVILLAVVIGVLLSGSCCECGCG 605

  Fly   884 ---ILCVVTY---ICR---QKQKAKKETVKM-----TMALSGCE---DSEPLRPSNIGANLCKLR 931
               .||.|.:   |.|   .|.|...|..||     .:.|.|..   |.......|...:    .
Human   606 RASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVH----E 666

  Fly   932 IVKDAE---LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMA 993
            ..|:.|   :....|:|.|.||.|..|.....|:. ::|||||.|......:...:||.||.||.
Human   667 FAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKR-ELPVAIKTLKVGYTEKQRRDFLGEASIMG 730

  Fly   994 SVEHVNLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEK 1057
            ..:|.|::.|..|...|: :|::|:.|..|.|..:::.|..:.....|:.....|:.||.||.:.
Human   731 QFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDM 795

  Fly  1058 RLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSN-EYKAAGGKMPIKWLALECIRNRVFTSKS 1121
            ..|||||||||:|:.:..:.|::||||:::|..|.. .|...|||:||:|.|.|.|..|.|||.|
Human   796 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSAS 860

  Fly  1122 DVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPT 1186
            |||::|:.:||::::|:||:..:..:|:...:|.|.:|..|..|...:|..:|.||..:...||.
Human   861 DVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPK 925

  Fly  1187 FKQLTTVFAEFARDP-------------------------------GRYL-AIPGDKFTRL---P 1216
            |.::..:..:..|:|                               |.:| ||...::|.:   .
Human   926 FDEIVNMLDKLIRNPSSLKTLVNASCRVSNLLAEHSPLGSGAYRSVGEWLEAIKMGRYTEIFMEN 990

  Fly  1217 AYTSQDE------KDLIRKLAPTTDGSE 1238
            .|:|.|.      :|| |:|..|..|.:
Human   991 GYSSMDAVAQVTLEDL-RRLGVTLVGHQ 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032	24/154 (16%)
		GF_recep_IV	572..684	CDD:464344	24/126 (19%)
		FU	662..716	CDD:214589	10/67 (15%)
		GF_recep_IV	740..>834	CDD:464344	20/141 (14%)
		PTKc_EGFR_like	930..1208	CDD:270648	98/314 (31%)
EPHA5	NP_001268694.1	EphR_LBD_A5	60..232	CDD:198451	16/98 (16%)
		FN3	<355..>598	CDD:442628	44/274 (16%)
		FN3	469..559	CDD:238020	8/89 (9%)
		EphA2_TM	576..673	CDD:464211	19/100 (19%)
		PTKc_EphR_A	671..937	CDD:270651	92/266 (35%)
		SAM_EPH-A5	966..1031	CDD:188945	14/53 (26%)