DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egfr and EGFR

DIOPT Version :9

Sequence 1:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_005219.2	Gene:	EGFR / 1956	HGNCID:	3236	Length:	1210	Species:	Homo sapiens

Alignment Length:	1383	Identity:	507/1383 - (36%)
Similarity:	702/1383 - (50%)	Gaps:	308/1383 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 RQRGGANFALGLGANGVTIPTS--LEDKNKNEFVKGKICIGTKSRLSVPSNKEHHYRNLRDRYTN 128
            |..|.|..|| |.......|.|  ||:|        |:|.||.::|:.....|.|:.:|:..:.|
Human     2 RPSGTAGAAL-LALLAALCPASRALEEK--------KVCQGTSNKLTQLGTFEDHFLSLQRMFNN 57

  Fly   129 CTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEK 193
            |..|.||||:|:: ..|.|||||..|:||.||:||:...|:::....||||||...:     |..
Human    58 CEVVLGNLEITYV-QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYY-----ENS 116

  Fly   194 YALFV--TY--SKMYTLEIP--DLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFT 252
            |||.|  .|  :|....|:|  :|:::|:|.|.|.||..||::.:|||.:|||:...:..:.||.
Human   117 YALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQ 181

  Fly   253 APERECPKCHESCTHG-CWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQ 316
            .....|.||..||.:| |||.|.:||||.:|:.|:.||: |||.|..|.:|||..||.|||||.:
Human   182 NHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCS-GRCRGKSPSDCCHNQCAAGCTGPRE 245

  Fly   317 KDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECP-GHLLRDNGACVRS 380
            .||:.|:.|.||..||:.|||:..||||||.::.||||||::||||||:|| .:::.|:|:|||:
Human   246 SDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRA 310

  Fly   381 CPQD--KMDKGG--ECVPCNGPCPKTCPGVTV--------LHAGNIDSFRNCTVIDGNIRILDQT 433
            |..|  :|::.|  :|..|.|||.|.|.|:.:        ::|.||..|:|||.|.|::.||...
Human   311 CGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVA 375

  Fly   434 FSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLM 498
            |.|     .::|..|   ||||:.|::..|||||||:|.|:.......:|..|.|||.|.||...
Human   376 FRG-----DSFTHTP---PLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQ 432

  Fly   499 ESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRA 563
            ...| :||:|..::.||.:|:||:||.|.|:|..|::|||.:.|.|..:.....||..:..|...
Human   433 HGQF-SLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGE 496

  Fly   564 DLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYK--FDNRTCKICHPE 626
            :.|:..|.:|...|:.:||||.....|::|:|.:....|:..|..:....:  .:|..|..||||
Human   497 NSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPE 561

  Fly   627 CR------TCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIG 685
            |.      ||.|.|.|:|.:|.|..||.|||..||.                 |..|..:|:
Human   562 CLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPA-----------------GVMGENNTL--- 606

  Fly   686 ACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNY 750
                                          .|:|..          ||. ||..|||
Human   607 ------------------------------VWKYAD----------AGH-VCHLCHP-------- 622

  Fly   751 GYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDA 815
                    .||:                                ||||||.:.|.:
Human   623 --------NCTY--------------------------------GCTGPGLEGCPT--------- 638

  Fly   816 NETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVP 880
              .||.:.|                                               |.||  :|.
Human   639 --NGPKIPS-----------------------------------------------IATG--MVG 652

  Fly   881 TICILCVVT----YICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKG 941
            .:.:|.||.    ...|::...:|.|::  ..|...|..|||.||....|...|||:|:.|.:|.
Human   653 ALLLLLVVALGIGLFMRRRHIVRKRTLR--RLLQERELVEPLTPSGEAPNQALLRILKETEFKKI 715

  Fly   942 GVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAV 1006
            .|||.||||.||||:|:||||.||||||||||.::|..::::|.|.|||:||||::.::.:||.:
Human   716 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI 780

  Fly  1007 CMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLV 1071
            |::|.:.|||||||.||||||||.::|.|||:.||||..||||||:|||::||||||||||||||
Human   781 CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV 845

  Fly  1072 QTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTF 1136
            :||..||||||||||||.::..||.|.|||:||||:|||.|.:|::|.:||||::|||:|||:||
Human   846 KTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTF 910

  Fly  1137 GQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDP 1201
            |.:|::.|||.:|..::|.|.:|.||.||::|:|..::.||.:||..||.|::|...|::.||||
Human   911 GSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDP 975

  Fly  1202 GRYLAIPGDKFTRLPAYTS-------QDEKDLIRKLAPTTDGSEAIAEPDDYLQPK----AAPGP 1255
            .|||.|.||:...||:.|.       .||:|:           :.:.:.|:||.|:    ::|..
Human   976 QRYLVIQGDERMHLPSPTDSNFYRALMDEEDM-----------DDVVDADEYLIPQQGFFSSPST 1029

  Fly  1256 SHRTD---------------CTD----------EIPKLNRYCKDPSNKNSSTGDDETDSSAREVG 1295
            | ||.               |.|          |...|.||..||:...:....|:|
Human  1030 S-RTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDT-------- 1085

  Fly  1296 VGNLRLDLPVDEDDYLMPTCQPGPNNNNNINNP---NQNNMAAVGVAAGYMDLIGVP--VSVDNP 1355
                  .|||.|  |:..:....|  ..::.||   ||....|......|.|    |  .:|.||
Human  1086 ------FLPVPE--YINQSVPKRP--AGSVQNPVYHNQPLNPAPSRDPHYQD----PHSTAVGNP 1136

  Fly  1356 EYLLNAQTLGVG---ESP 1370
            |||...|...|.   :||
Human  1137 EYLNTVQPTCVNSTFDSP 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	53/127 (42%)
		GF_recep_IV	572..684	CDD:291509	36/119 (30%)
		FU	573..>606	CDD:238021	10/32 (31%)
		FU	617..659	CDD:214589	22/47 (47%)
		FU	662..716	CDD:214589	3/53 (6%)
		FU	739..786	CDD:238021	5/46 (11%)
		FU	784..834	CDD:214589	10/49 (20%)
		PTKc_EGFR_like	930..1208	CDD:270648	165/277 (60%)
		STYKc	938..1194	CDD:214568	152/255 (60%)
		Recep_L_domain	128..239	CDD:279382	49/116 (42%)
		Furin-like	253..401	CDD:279142	78/153 (51%)
		FU	255..292	CDD:214589	18/37 (49%)
		FU	302..345	CDD:238021	24/42 (57%)
EGFR	NP_005219.2	Recep_L_domain	57..168	CDD:279382	49/116 (42%)
		Approximate	75..300		109/230 (47%)
		Furin-like	185..335	CDD:279142	78/150 (52%)
		FU	231..274	CDD:238021	24/42 (57%)
		Recep_L_domain	361..481	CDD:279382	53/128 (41%)
		Approximate	390..600		77/227 (34%)
		GF_recep_IV	505..637	CDD:291509	53/240 (22%)
		FU	506..559	CDD:238021	13/52 (25%)
		FU	552..598	CDD:214589	22/62 (35%)
		TM_ErbB1	634..677	CDD:213054	12/102 (12%)
		Important for dimerization, phosphorylation and activation	688..704		6/15 (40%)
		PTKc_EGFR	704..1016	CDD:270683	175/322 (54%)
		TyrKc	713..968	CDD:197581	152/254 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1097..1137		11/45 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	339	1.000	Domainoid score	I1096
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	607	1.000	Inparanoid score	I933
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm40594
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5222
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870