DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and nipi-4

DIOPT Version :9

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_505028.3 Gene:nipi-4 / 179167 WormBaseID:WBGene00077712 Length:396 Species:Caenorhabditis elegans


Alignment Length:348 Identity:96/348 - (27%)
Similarity:152/348 - (43%) Gaps:70/348 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   885 LCVVTYICRQKQKAKKETVKMTMALSGCED-SEPLRPSNIGANLCKL-RIVKDAELRKGGV---- 943
            |..:.|.|::.:|.             |:. |:.:.|..  ..|.:| |.:|:..:.:..:    
 Worm    35 LLAIFYFCKKSKKM-------------CQPMSDSIYPYQ--KRLTQLERELKNYLIDEESIEVDD 84

  Fly   944 --LGMGAFGRVYKGVWVPEGE---NVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKL 1003
              :|..|.|.:::|...|:..   |.|:..|:|  :.......|...|.:|..::.::|.||::|
 Worm    85 FQIGQTADGFIFRGGVFPKTRNRFNAKVTTAVK--ISFPIVSKSISLLEDALRLSKLDHPNLIRL 147

  Fly  1004 LAVCMSS----QMMLITQLMPLGCLLDYVR--------NNRDKIGSKALLNWSTQIAKGMSYLEE 1056
            |||...|    :.|:..:.:|.|.|.||.:        :.|..|..|.:|:...|:::.:.|:..
 Worm   148 LAVSQLSFTVFRPMIALEWLPGGTLADYFQFKVREKDDSERSPIQLKDMLSILYQVSQALKYIHS 212

  Fly  1057 ------KRLVHRDLAARNVLVQTPSL----VKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALEC 1111
                  :.|.|..:..|||||..|.|    ||:.|||.|.:....|....|   .||.:.|   |
 Worm   213 QLDEFGQELTHGRIFTRNVLVTEPDLRKCEVKLGDFGDAPMGLEYSTPIIA---YMPPEIL---C 271

  Fly  1112 IRNRV--FTSKSDVWAFGVTIWELLTFGQRPHENIPAKDI------PDLIEVGLKLEQPEICSLD 1168
            ...|:  ...::|||.|||.|||.||.|.:||.....::|      ||.   ||..  |..|.||
 Worm   272 CAERIPPHRPENDVWMFGVFIWECLTLGAQPHFRKSVEEIKKSFRLPDR---GLSC--PPTCPLD 331

  Fly  1169 IYCTLLSCWHLDAAMRPTFKQLT 1191
            :: ||:|....:..|||.|...|
 Worm   332 VW-TLVSDCLSEPHMRPRFASTT 353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382
GF_recep_IV 572..684 CDD:291509
FU 573..>606 CDD:238021
FU 617..659 CDD:214589
FU 662..716 CDD:214589
FU 739..786 CDD:238021
FU 784..834 CDD:214589
PTKc_EGFR_like 930..1208 CDD:270648 88/302 (29%)
STYKc 938..1194 CDD:214568 85/293 (29%)
Recep_L_domain 128..239 CDD:279382
Furin-like 253..401 CDD:279142
FU 255..292 CDD:214589
FU 302..345 CDD:238021
nipi-4NP_505028.3 PKc_like 86..350 CDD:304357 83/277 (30%)
Pkinase_Tyr 87..350 CDD:285015 83/276 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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