DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and F57B9.8

DIOPT Version :9

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_498511.1 Gene:F57B9.8 / 175967 WormBaseID:WBGene00018999 Length:444 Species:Caenorhabditis elegans


Alignment Length:373 Identity:92/373 - (24%)
Similarity:163/373 - (43%) Gaps:72/373 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   936 AELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNL 1000
            |::....|||.||||.|..|........|.:.:.:.:|.|.| .|..:|.:.||.:|...:|.|:
 Worm   113 ADITMTKVLGEGAFGEVKLGTLKMGSTTVDVAIKVAKLEKVT-KEQIKEIITEARLMRGFDHKNV 176

  Fly  1001 LKLLAV-CMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWS------TQIAKGMSYLEEKR 1058
            :|...| .:...::::.:|:|.|.|..|::.|       :.:.|.      .|:|.|::|:..|.
 Worm   177 VKCYGVAAIDEPLLVVMELVPGGALDKYLQKN-------SSVQWPEKLDIIAQVAAGLAYIHSKN 234

  Fly  1059 LVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGK-MPIKWLALECIRNRVFTSKSD 1122
            ::|||:||||:| ....:.|::||||:::    ..||:....| :||:||:.|.|.:.::|.::|
 Worm   235 IIHRDIAARNIL-YGKGVAKVSDFGLSRV----GTEYQMDPSKRVPIRWLSPETIVSFLYTPQTD 294

  Fly  1123 VWAFGVTIWELLTFGQRP---------HENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWH 1178
            |:||.:..||::..|.:|         |:.:...|    ..:.:..:.|.:.: |:   :..||.
 Worm   295 VFAFSILCWEVIENGAQPYPEMLVVQVHQKVGRDD----YRMPISQKAPAMLA-DV---IKKCWI 351

  Fly  1179 LDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAEP 1243
            .|...|||..|:..:..|.                     |.:.:|..:.|.............|
 Worm   352 RDPQQRPTMSQVVQMMYEI---------------------TGKKDKTSVNKSTGQLRAKMMSTGP 395

  Fly  1244 -DDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDETDSS 1290
             .|.::.|.|.....|..            |.||:.::..|.:...||
 Worm   396 MSDPMRDKTAKKTGRRNK------------KKPSSASNGPGGNSGPSS 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382
GF_recep_IV 572..684 CDD:291509
FU 573..>606 CDD:238021
FU 617..659 CDD:214589
FU 662..716 CDD:214589
FU 739..786 CDD:238021
FU 784..834 CDD:214589
PTKc_EGFR_like 930..1208 CDD:270648 78/288 (27%)
STYKc 938..1194 CDD:214568 76/272 (28%)
Recep_L_domain 128..239 CDD:279382
Furin-like 253..401 CDD:279142
FU 255..292 CDD:214589
FU 302..345 CDD:238021
F57B9.8NP_498511.1 SH2_Fps_family 1..91 CDD:198224
STYKc 115..367 CDD:214568 76/272 (28%)
PTKc 119..367 CDD:270623 76/268 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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