DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and Erbb4

DIOPT Version :9

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_006495755.1 Gene:Erbb4 / 13869 MGIID:104771 Length:1308 Species:Mus musculus


Alignment Length:1447 Identity:506/1447 - (34%)
Similarity:692/1447 - (47%) Gaps:354/1447 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 LGANGVTIPTSLEDKNKNEFVKGKICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWL 141
            |.|.|...|::.:          .:|.||:::||..|:.|..||.||..|.||..|.||||:|.:
Mouse    14 LMAAGTVQPSASQ----------SVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSI 68

  Fly   142 PNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYAL--FVTYSK-- 202
             ..|.|||||.:|||||||:|::....:.:....|:||||..|:     |::|||  |:.|.|  
Mouse    69 -EHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLY-----EDRYALAIFLNYRKDG 127

  Fly   203 ---MYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHES 264
               :..|.:.:|.::|||.|....|..||:..||.|.:||.|...:......|.....|.:||:|
Mouse   128 NFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTNGSSGCGRCHKS 192

  Fly   265 CTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEG 329
            ||..|||....:||..::..|:.|| .||||||...:|||..|||||:||...||.||.||.|.|
Mouse   193 CTGRCWGPTENHCQTLTRTVCAEQC-DGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSG 256

  Fly   330 VCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKM--DKGG-- 390
            .|..:||....|||||:.||.|...||.|||.|||:||.:.:.|:.:|||:||..||  ::.|  
Mouse   257 ACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIK 321

  Fly   391 ECVPCNGPCPKTCPGV--------TVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMG 447
            .|.||...|||.|.|:        ..:.:.|||.|.|||.|:||:..|.....|  |.|....  
Mouse   322 MCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHG--DPYNAID-- 382

  Fly   448 PRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSL 512
                .:|||:|.||.||:||||:|||:...|...:.|.|.||.||.||.|...: :.|.:.:..:
Mouse   383 ----AIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGL-SLLILKQQGI 442

  Fly   513 YSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQC 577
            .||:.::||:||:|::.|..|.:|||...|.|..:.....|::.:.:|.||:.|...|.:|:..|
Mouse   443 TSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLC 507

  Fly   578 NEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYK-FDNRT-CKICHPECR-------TCNGA 633
            :.|||||.|.||||:|:.|:....||..|......:: |:|.: |..|..:|.       ||:|.
Mouse   508 SNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGP 572

  Fly   634 GADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINND 698
            |.|:|.:|.|.:||.:||.:||                 ||..|....|                
Mouse   573 GPDNCTKCSHFKDGPNCVEKCP-----------------DGLQGANSFI---------------- 604

  Fly   699 ATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHY 763
                                                                            :
Mouse   605 ----------------------------------------------------------------F 605

  Fly   764 KRREQCETECPADHYTDEEQRECFQCHPEC-NGCTGPGADDCKSCRNFKLFDANETGPYVNSTMF 827
            |             |.|:: |||..|||.| .||.||.:.||                       
Mouse   606 K-------------YADQD-RECHPCHPNCTQGCNGPTSHDC----------------------- 633

  Fly   828 NCTSKCPLEMRHVNYQYTAIG--PYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTY 890
                        :.|.:|...  |..|.:|..::.:...|.:.:|..:|.||.|           
Mouse   634 ------------IYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYV----------- 675

  Fly   891 ICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKG 955
              |:|...||..::..:.   .|..|||.||....|..:|||:|:.||::..|||.||||.||||
Mouse   676 --RRKSIKKKRALRRFLE---TELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKG 735

  Fly   956 VWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMP 1020
            :||||||.||||||||.|.::||.:::.||:.||.||||::|.:|::||.||:|..:.|:|||||
Mouse   736 IWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMP 800

  Fly  1021 LGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLA 1085
            .|||||||..::|.|||:.||||..||||||.||||:||||||||||||||::|:.|||||||||
Mouse   801 HGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLA 865

  Fly  1086 KLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIP 1150
            :||..|..||.|.||||||||:|||||..|.||.:||||::|||||||:|||.:|::.||.::||
Mouse   866 RLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIP 930

  Fly  1151 DLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRL 1215
            ||:|.|.:|.||.||::|:|..::.||.:||..||.||:|...|:..||||.|||.|.||...:|
Mouse   931 DLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKL 995

  Fly  1216 PAYTSQ-------DEKDLIRKLAPTTDGSEAIAEPDDYLQPKA--APGP---------SHRTDCT 1262
            |:....       ||:||           |.:.:.::||.|:|  .|.|         |:|::..
Mouse   996 PSPNDSKFFQNLLDEEDL-----------EDMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRSEIG 1049

  Fly  1263 DEIPKL------NRYCKD------------PSNKNSST--------------GDD---------- 1285
            ...|..      |::...            |....:||              .||          
Mouse  1050 HSPPPAYTPMSGNQFVYQDGGFATQQGMPMPYRATTSTIPEAPVAQGATAEMFDDSCCNGTLRKP 1114

  Fly  1286 -----ETDSSAREVGVG--------NLRLDLPVDEDDYLMPTCQPGPNNNNNINNPNQNNMAAVG 1337
                 :.|||.:.....        |.|.:|  ||:.|:.|.   .........||.:.|.....
Mouse  1115 VAPHVQEDSSTQRYSADPTVFAPERNPRGEL--DEEGYMTPM---HDKPKQEYLNPVEENPFVSR 1174

  Fly  1338 VAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPVMGVPGTMEVKVPMPGSEPTSSD 1402
            ...|.:.      ::|||||                                  ....|.|..::
Mouse  1175 RKNGDLQ------ALDNPEY----------------------------------HSASSGPPKAE 1199

  Fly  1403 HEYYNDTQRELQPLHRN 1419
            .||.|      :||:.|
Mouse  1200 DEYVN------EPLYLN 1210

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382 50/127 (39%)
GF_recep_IV 572..684 CDD:291509 40/120 (33%)
FU 573..>606 CDD:238021 16/32 (50%)
FU 617..659 CDD:214589 18/49 (37%)
FU 662..716 CDD:214589 4/53 (8%)
FU 739..786 CDD:238021 4/46 (9%)
FU 784..834 CDD:214589 13/50 (26%)
PTKc_EGFR_like 930..1208 CDD:270648 173/277 (62%)
STYKc 938..1194 CDD:214568 160/255 (63%)
Recep_L_domain 128..239 CDD:279382 47/117 (40%)
Furin-like 253..401 CDD:279142 72/151 (48%)
FU 255..292 CDD:214589 14/36 (39%)
FU 302..345 CDD:238021 24/42 (57%)
Erbb4XP_006495755.1 Recep_L_domain 55..165 CDD:366426 47/115 (41%)
Furin-like 186..334 CDD:366287 74/148 (50%)
Recep_L_domain 358..475 CDD:366426 49/125 (39%)
GF_recep_IV 502..634 CDD:373332 56/277 (20%)
TM_ErbB4 642..685 CDD:213053 13/55 (24%)
PTKc_HER4 710..1012 CDD:173655 180/301 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 341 1.000 Domainoid score I1078
eggNOG 1 0.900 - - E1_KOG1025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45861
OrthoDB 1 1.010 - - D51516at33208
OrthoFinder 1 1.000 - - FOG0000755
OrthoInspector 1 1.000 - - otm42670
orthoMCL 1 0.900 - - OOG6_101159
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5222
SonicParanoid 1 1.000 - - X448
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.820

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