DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egfr and Erbb3

DIOPT Version :9

Sequence 1:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_034283.1	Gene:	Erbb3 / 13867	MGIID:	95411	Length:	1339	Species:	Mus musculus

Alignment Length:	1446	Identity:	467/1446 - (32%)
Similarity:	648/1446 - (44%)	Gaps:	351/1446 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 ICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISH 165
            :|.||.:.|||..:.::.|:.|...|..|..|.||||:. |...|.|||||..|||||||:|::.
Mouse    28 VCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEIV-LTGHNADLSFLQWIREVTGYVLVAM 91

  Fly   166 VDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYS-------KMYTLEIPDLRDVLNGQVGFHN 223
            .:...:..|.|:::||..::     :.|:|:||..:       .:..|....|.::|.|.|....
Mouse    92 NEFSVLPLPNLRVVRGTQVY-----DGKFAIFVMLNYNTNSSHALRQLRFTQLTEILLGGVYIEK 151

  Fly   224 NYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERE---------CPKCHESCTHGCWGEGPKNCQK 279
            |..||||.||.|.:||            ..|:.|         ||.|||.|...|||.||::||.
Mouse   152 NDKLCHMDTIDWRDIV------------RVPDAEIVVKNNGGNCPPCHEVCKGRCWGPGPEDCQI 204

  Fly   280 FSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPT 344
            .:|..|:||| .|||:||.|.:|||..|||||:||...||.||::|.|.|.|...||....||..
Mouse   205 LTKTICAPQC-NGRCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKL 268

  Fly   345 TYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKM--DKGG--ECVPCNGPCPKTCPG 405
            |:.||.||..||.||..||..||.:.:.|...|||:||.|||  ||.|  .|.||.|.|||.|.|
Mouse   269 TFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGLKMCEPCRGLCPKACEG 333

  Fly   406 V------TVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIP-LDPERLEVFST 463
            .      ..:.:.|||.|.|||.|.||:..|....:|  |.:       ..|| ||||:|.||.|
Mouse   334 TGSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNG--DPW-------HKIPALDPEKLNVFRT 389

  Fly   464 VKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSV 528
            |:||||||||:...|...|.|.|.||.||.||.|....|:.|.:...::.||..|:||:||:|.|
Mouse   390 VREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRV 454

  Fly   529 VIQHNRDLCYVSNIRWPAIQKEP-EQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLT 592
            .|..|:.|||..::.|..:.:.| |:::.:..|.....|...|.:|...|:..||||.|..|||:
Mouse   455 YISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGECVAEGKVCDPLCSSGGCWGPGPGQCLS 519

  Fly   593 CKNFNFNGTCIADCG--------YISNAYKFDNRTCKICHPECR------TCNGAGADHCQECVH 643
            |:|::..|.|:..|.        ::..|:      |..|||||:      ||||:|:|.|..|.|
Mouse   520 CRNYSREGVCVTHCNVLQGEPREFVHEAH------CFSCHPECQPMEGTSTCNGSGSDACARCAH 578

  Fly   644 VRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKD 708
            .|||.|||:.||                 .|..|.|..|
Mouse   579 FRDGPHCVNSCP-----------------HGILGAKGPI-------------------------- 600

  Fly   709 DKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETEC 773
                      |.:|..|..         ||.||   |.||
Mouse   601 ----------YKYPDAQNE---------CRPCH---ENCT------------------------- 618

  Fly   774 PADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMR 838
                                .||.||...||                              |...
Mouse   619 --------------------QGCKGPELQDC------------------------------LGQA 633

  Fly   839 HVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETV 903
            .|          ..:.|.....:|..|.|  ||:|.|...:          |...::.:.|:
Mouse   634 EV----------LMSKPHLVIAVTVGLTV--IFLILGGSFL----------YWRGRRIQNKR--- 673

  Fly   904 KMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPV 968
            .|...|...|..|||.||. .||....||.|:.||||..|||.|.||.|:||:|:||||::||||
Mouse   674 AMRRYLERGESIEPLDPSE-KANKVLARIFKETELRKLKVLGSGVFGTVHKGIWIPEGESIKIPV 737

  Fly   969 AIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRD 1033
            .||.:...:|.:|.:........:.|::|.::::||.:|..|.:.|:||.:|||.|||:||.:|:
Mouse   738 CIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRE 802

  Fly  1034 KIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAA 1098
            .:|.:.||||..||||||.||||..:||||||.|||::::||.|::.|||:|.||..|..:...:
Mouse   803 TLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHS 867

  Fly  1099 GGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPE 1163
            ..|.||||:|||.|....:|.:||||::|||:|||:|||..|:..:...:||||:|.|.:|.||:
Mouse   868 EAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQ 932

  Fly  1164 ICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAI-----PGDKFTRLP-AYTSQD 1222
            ||::|:|..::.||.:|..:|||||:|...|...||||.|||.|     ||......| |.::::
Mouse   933 ICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRASGPGIPPAAEPSALSTKE 997

  Fly  1223 EKDLIRKLAPTTD-------------------------------GSEAIAEPDDYLQP------- 1249
            .:|  .:|.|..|                               ||:::..|.....|
Mouse   998 LQD--AELEPDLDLDLDVEVEEEGLATTLGSALSLPTGTLTRPRGSQSLLSPSSGYMPMNQSNLG 1060

  Fly  1250 -------------------KAAPGP----------SHRTDCTDEIPKLNRYCKDPSNKNS--STG 1283
                               ...|.|          .|.|....|:.:....|:..|...|  ..|
Mouse  1061 EACLDSAVLGGREQFSRPISLHPIPRGRQTSESSEGHVTGSEAELQERVSMCRSRSRSRSPRPRG 1125

  Fly  1284 DDETDSSAREVGVGNLRLDLP-VDEDD---YLMPTCQPGPNNNNNINNPNQNNMAAVGVAAGYMD 1344
            |....|....:......|..| ::|:|   |:||     ..:....::..:..:::||:::
Mouse  1126 DSAYHSQRHSLLTPVTPLSPPGLEEEDGNGYVMP-----DTHLRGTSSSREGTLSSVGLSS---- 1181

  Fly  1345 LIGVPVSVDNPEY-LLNAQTLG-VGESPIP--TQTIGIPVMGVPGTMEVK--------------V 1391
            ::|.....::.|| .:|.:..| ....|.|  .:.:|...|.|...:...              |
Mouse  1182 VLGTEEEDEDEEYEYMNRKRRGSPARPPRPGSLEELGYEYMDVGSDLSASLGSTQSCPLHPMAIV 1246

  Fly  1392 PMPGSEPTSSDHEYYN 1407
            |..|:.| ..|:||.|
Mouse  1247 PSAGTTP-DEDYEYMN 1261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	56/128 (44%)
		GF_recep_IV	572..684	CDD:291509	43/125 (34%)
		FU	573..>606	CDD:238021	14/32 (44%)
		FU	617..659	CDD:214589	23/47 (49%)
		FU	662..716	CDD:214589	4/53 (8%)
		FU	739..786	CDD:238021	5/46 (11%)
		FU	784..834	CDD:214589	6/49 (12%)
		PTKc_EGFR_like	930..1208	CDD:270648	136/282 (48%)
		STYKc	938..1194	CDD:214568	123/255 (48%)
		Recep_L_domain	128..239	CDD:279382	42/117 (36%)
		Furin-like	253..401	CDD:279142	78/160 (49%)
		FU	255..292	CDD:214589	19/45 (42%)
		FU	302..345	CDD:238021	22/42 (52%)
Erbb3	NP_034283.1	Recep_L_domain	56..167	CDD:279382	42/116 (36%)
		Furin-like	179..329	CDD:279142	76/150 (51%)
		FU	180..215	CDD:214589	18/35 (51%)
		FU	226..266	CDD:238021	20/39 (51%)
		Recep_L_domain	353..474	CDD:279382	56/129 (43%)
		GF_recep_IV	499..630	CDD:291509	59/276 (21%)
		FU	500..542	CDD:238021	15/41 (37%)
		FU	548..592	CDD:214589	23/66 (35%)
		TM_ErbB3	638..674	CDD:213056	10/50 (20%)
		PKc_like	699..977	CDD:304357	135/277 (49%)
		Pkinase_Tyr	707..963	CDD:285015	123/255 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1028..1052		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1077..1156		15/78 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1212		6/34 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6228
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm42670
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.790