Protein Alignment Egfr and Ephb4

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001153043.1
• Gene: Ephb4 / 13846
• MGIID: 104757
• Length: 996
• Species: Mus musculus
• Alignment Length: 730
• Identity: 188/730 - (25%)
• Similarity: 283/730 - (38%)
• Gaps: 183/730 - (25%)

  Fly   577 CNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHCQEC 641
            |.|||.|   .:|.:|        .|....||.:..   .|:.|:.|        |.|....|
Mouse   239 CREDGQW---AEQQVT--------GCSCAPGYEAAE---SNKVCRAC--------GQGTFKPQ-- 279

  Fly   642 VHVRDGQHCVSECPKNKY-NDRG----VCR--ECHATCDGCTGPKDTIGIGACTT---CNLAIIN 696
                .|......||.|.: |:.|    :||  ...|..|..:.|        |||   ...::::
Mouse   280 ----IGDESCLPCPANSHSNNIGSPVCLCRIGYYRARSDPRSSP--------CTTPPSAPRSVVH 332

  Fly   697 --NDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHP--LCELC---------- 747
              |.:|::              .|:..|.|.|..:.|.....||:|.|  .|..|
Mouse   333 HLNGSTLR--------------LEWSAPLESGGREDLTYAVRCRECRPGGSCLPCGGDMTFDPGP 383

  Fly   748 ----------------TNYGYH----EQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPE 792
                            ..|.:.    ..|.:..|.....|      |.:..||.|.|..|
Mouse   384 RDLVEPWVAIRGLRPDVTYTFEVAALNGVSTLATGPPPFE------PVNVTTDREGRIGF----- 437

  Fly   793 CNGCTGPGADDCKSCRN-----------------------FKLFDANETGPYVNSTMFNCTSKCP 834
            .:....|...|.:..|:                       .|..:....||  :|..|..||:..
Mouse   438 LSPAVPPAVSDIRVTRSSPSSLILSWAIPRAPSGAVLDYEVKYHEKGAEGP--SSVRFLKTSENR 500

  Fly   835 LEMRHV----NY-------QYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVV 888
            .|:|.:    :|       .....||:......::....:......:.:|.|..:|..:.:|.||
Mouse   501 AELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESESWREQLALIAGTAVVGVVLVLVVV 565

  Fly   889 --TYICRQKQKAKKET--------------VKMTMALSGCED-SEPLRPSNIGANLCKLRIVKDA 936
              ..:|.:||...:|.              .|:.:.....|| :|.:|..   |....:..||..
Mouse   566 IIAVLCLRKQSNGREVEYSDKHGQYLIGHGTKVYIDPFTYEDPNEAVREF---AKEIDVSYVKIE 627

  Fly   937 ELRKGGVLGMGAFGRVYKGVWVPEGENVKIP------VAIKELLKSTGAESSEEFLREAYIMASV 995
            |     |:|.|.||.|.:|       .:|.|      ||||.|..........|||.||.||...
Mouse   628 E-----VIGAGEFGEVCRG-------RLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQF 680

  Fly   996 EHVNLLKLLAVCMSS-QMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRL 1059
            ||.|:::|..|..:| .:|::|:.|..|.|..::|.|..:.....|:.....||.||.||.|...
Mouse   681 EHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSY 745

  Fly  1060 VHRDLAARNVLVQTPSLVKITDFGLAKLL---SSDSNEYKAAGGKMPIKWLALECIRNRVFTSKS 1121
            |||||||||:||.:..:.|::||||::.|   |||.....:.|||:||:|.|.|.|..|.|||.|
Mouse   746 VHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSAS 810

  Fly  1122 DVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPT 1186
            |.|::|:.:||:::||:||:.::..:|:.:.||...:|..|..|...::..:|.||..|...||.
Mouse   811 DAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPR 875

  Fly  1187 FKQLTTVFAEFARDP 1201
            |.|:.:...:..|:|
Mouse   876 FPQVVSALDKMIRNP 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032
		GF_recep_IV	572..684	CDD:464344	27/113 (24%)
		FU	662..716	CDD:214589	11/64 (17%)
		GF_recep_IV	740..>834	CDD:464344	24/148 (16%)
		PTKc_EGFR_like	930..1208	CDD:270648	104/282 (37%)
Ephb4	NP_001153043.1	EphR_LBD_B4	17..196	CDD:198442
		FN3	324..429	CDD:238020	18/124 (15%)
		fn3	444..527	CDD:394996	14/84 (17%)
		EphA2_TM	<573..621	CDD:464211	9/50 (18%)
		PTKc_EphR_B	619..887	CDD:173638	102/279 (37%)
		SAM_EPH-B4	916..982	CDD:188953
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	974..996
		PDZ-binding. /evidence=ECO:0000255	994..996