Protein Alignment Egfr and Epha5

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_006534832.1
• Gene: Epha5 / 13839
• MGIID: 99654
• Length: 1040
• Species: Mus musculus
• Alignment Length: 1007
• Identity: 219/1007 - (21%)
• Similarity: 359/1007 - (35%)
• Gaps: 306/1007 - (30%)

  Fly   416 SFRNCTVIDGNIRILDQTFSGF----QDVYANYTMGPRYIPLDP-------------ERLEVFST 463
            :.|:|..:.|.:....:||:.:    .|.........:||.:|.             :|:...:|
Mouse   135 TLRDCNSLPGGLGTCKETFNMYYFESDDENGRSIKENQYIKIDTIAADESFTELDLGDRVMKLNT 199

  Fly   464 VKEITGYLNIEGTHPQFRNLS----------YFRNLETIHGRQLMESMFAALAIVKSSLYSLEMR 518
            .....|.|:.:|.:..|:::.          |::.         ..|:...|||...::...:..
Mouse   200 EVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKK---------CPSVVRHLAIFPDTITGADSS 255

  Fly   519 NLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSD----QCNE 579
            .|.:: |||.|                                       |.::..|    .|:.
Mouse   256 QLLEV-SGSCV---------------------------------------NHSVTDDPPKMHCSA 280

  Fly   580 DGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNG--AGADHCQECV 642
            :|.|.....:|: ||                ..|:..|.||::|.|      |  ..:.|.|.|
Mouse   281 EGEWLVPIGKCM-CK----------------AGYEEKNGTCQVCRP------GFFKASPHSQTC- 321

  Fly   643 HVRDGQHCVSECPKNKYNDRGVCRECHATCD-------------GCTGPKDTIGIGACTTCNLAI 694
                     |:||.:.|........|  .|:             .||.|.        :....||
Mouse   322 ---------SKCPPHSYTHEEASTSC--VCEKDYFRKDSDPPTMACTRPP--------SAPRNAI 367

  Fly   695 IN-NDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCS 758
            .| |:.:|              |.|::.|.:.|..|.::....|:||:....:|...|.|.:...
Mouse   368 SNVNETSV--------------FLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLP 418

  Fly   759 KCTHYKRREQCETECPA-DHYTDEEQRECFQCHPECNGCT--GPGADDC---------------- 804
            :....|.......:..| .:||.|.:        ..||.:  .||....
Mouse   419 QQIGLKNTSVMMVDLLAHTNYTFEIE--------AVNGVSDLSPGTRQYVSVNVTTNQAAPSPVT 475

  Fly   805 -----KSCRN--------------------FKLFDANETGPYV----NSTMFNCTSKCPLEM--- 837
                 |..:|                    .|.|:.::...|.    ..|........|..:
Mouse   476 NVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETSITAEGLKPASVYVF 540

  Fly   838 --------------RHVNYQYTAIGPYCAASPPRSS----KITANLDVNMIFIITGAVLVPTIC- 883
                          |...::.|.:.  .|||..:|.    .::..:.|.::.::.|.:|..:.|
Mouse   541 QIRARTAAGYGVFSRRFEFETTPVS--VAASNDQSQIPIIAVSVTVGVILLAVMIGFLLSGSCCD 603

  Fly   884 -------ILCVVTY---ICR---QKQKAKKETVKM-----TMALSGCE---DSEPLRPSNIGANL 927
                   .||.|.:   |.|   .|.|...|..||     .:.|.|..   |.......|...:
Mouse   604 CGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVH- 667

  Fly   928 CKLRIVKDAE---LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREA 989
               ...|:.|   :....|:|.|.||.|..|.....|:. ::|||||.|......:...:||.||
Mouse   668 ---EFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKR-ELPVAIKTLKVGYTEKQRRDFLGEA 728

  Fly   990 YIMASVEHVNLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSY 1053
            .||...:|.|::.|..|...|: :|::|:.|..|.|..:::.|..:.....|:.....||.||.|
Mouse   729 SIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKY 793

  Fly  1054 LEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSN-EYKAAGGKMPIKWLALECIRNRVF 1117
            |.:...|||||||||:|:.:..:.|::||||:::|..|.. .|...|||:||:|.|.|.|..|.|
Mouse   794 LSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKF 858

  Fly  1118 TSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAA 1182
            ||.||||::|:.:||::::|:||:..:..:|:...:|.|.:|..|..|...:|..:|.||..|..
Mouse   859 TSSSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRN 923

  Fly  1183 MRPTFKQLTTVFAEFARDP-------------------------------GRYL-AIPGDKFTRL 1215
            .||.|.::..:..:..|:|                               |.:| ||...::|.:
Mouse   924 SRPKFDEIVNMLDKLIRNPSSLKTLVNASSRVSTLLAEHGSLGSGAYRSVGEWLEAIKMGRYTEI 988

  Fly  1216 ---PAYTSQDE------KDLIRKLAPTTDGSE 1238
               ..|:|.|.      :|| |:|..|..|.:
Mouse   989 FMENGYSSMDAVAQVTLEDL-RRLGVTLVGHQ 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032	24/154 (16%)
		GF_recep_IV	572..684	CDD:464344	26/130 (20%)
		FU	662..716	CDD:214589	10/67 (15%)
		GF_recep_IV	740..>834	CDD:464344	19/141 (13%)
		PTKc_EGFR_like	930..1208	CDD:270648	100/314 (32%)
Epha5	XP_006534832.1	EphR_LBD	62..234	CDD:470656	16/98 (16%)
		FN3	<357..>600	CDD:442628	43/274 (16%)
		FN3	471..561	CDD:238020	8/89 (9%)
		EphA2_TM	578..675	CDD:464211	19/100 (19%)
		PTKc_EphR_A	673..939	CDD:270651	94/266 (35%)
		SAM_EPH-A5	968..1033	CDD:188945	14/53 (26%)