Protein Alignment Egfr and Epha2

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_034269.2
• Gene: Epha2 / 13836
• MGIID: 95278
• Length: 977
• Species: Mus musculus
• Alignment Length: 937
• Identity: 215/937 - (22%)
• Similarity: 333/937 - (35%)
• Gaps: 247/937 - (26%)

  Fly   418 RNCTVIDGNIRILDQTFSGF---QDV-YANYTMGPRYIPLD---PERLEVFSTVKEITGYLNIEG 475
            |:|....|......:||:.:   .|| |.......::..:|   |:.:.|.|..:.....||:|.
Mouse   102 RDCNSFPGGASSCKETFNLYYAESDVDYGTNFQKRQFTKIDTIAPDEITVSSDFEARNVKLNVEE 166

  Fly   476 --THPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCY 538
              ..|..|...|.          ..:.:.|.:|::...:|..:...:.|
Mouse   167 RMVGPLTRKGFYL----------AFQDIGACVALLSVRVYYKKCPEMLQ---------------- 205

  Fly   539 VSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSD-------------QCNEDGCWGAGTDQC 590
             |..|:|       :.:.|..:....|....|| |.|             .|..||.|.....||
Mouse   206 -SLARFP-------ETIAVAVSDTQPLATVAGT-CVDHAVVPYGGEGPLMHCTVDGEWLVPIGQC 261

  Fly   591 LTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHP----------ECRTC------NGAGADHCQ 639
            | |:                ..|:.....|:.|.|          .|..|      :..||..||
Mouse   262 L-CQ----------------EGYEKVEDACRACSPGFFKSEASESPCLECPEHTLPSTEGATSCQ 309

  Fly   640 ECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKD------TIGIGACTTCNLAIINND 698
             |   .:|.....|.|.:.               .||.|..      .||:||....
Mouse   310 -C---EEGYFRAPEDPLSM---------------SCTRPPSAPNYLTAIGMGAKVEL-------- 347

  Fly   699 ATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHP------LCELCTNYGYHEQVC 757
                               .:..|::.|..:.:.....|.:|.|      .||....|
Mouse   348 -------------------RWTAPKDTGGRQDIVYSVTCEQCWPESGECGPCEASVRY------- 386

  Fly   758 SKCTHYKRREQCETEC--PADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKL--FDANET 818
            |:..|...|.......  |..:||...:..        ||.:|     ..:.|:|:.  ...|:|
Mouse   387 SEPPHALTRTSVTVSDLEPHMNYTFAVEAR--------NGVSG-----LVTSRSFRTASVSINQT 438

  Fly   819 GPYV------NSTMFNCTSKCPLEMRHVNYQYTAI----GPYCAASPPRSSKITANLD------- 866
            .|..      ::|..:.|...|:..:...::|...    |...:.:..|:...:..||
Mouse   439 EPPKVRLEDRSTTSLSVTWSIPVSQQSRVWKYEVTYRKKGDANSYNVRRTEGFSVTLDDLAPDTT 503

  Fly   867 ------------------------------VNMIFIITGAVLVPTICILC---VVTYICRQKQKA 898
                                          .||..|  |.|.|..:.:|.   |..:|.|:::..
Mouse   504 YLVQVQALTQEGQGAGSKVHEFQTLSTEGSANMAVI--GGVAVGVVLLLVLAGVGLFIHRRRRNL 566

  Fly   899 KKETVKMTMALSGCEDSEPLR----PSNI-GANLCKLRIVKDAE---LRKGGVLGMGAFGRVYKG 955
            :.......:..|..|..:||:    |... ..|...|:...:..   :.:..|:|.|.||.||||
Mouse   567 RARQSSEDVRFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVARQKVIGAGEFGEVYKG 631

  Fly   956 VWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMS-SQMMLITQLM 1019
            .........:||||||.|......:...:||.||.||....|.|:::|..|... ..||:||:.|
Mouse   632 TLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIRLEGVVSKYKPMMIITEYM 696

  Fly  1020 PLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGL 1084
            ..|.|..::|....:.....|:.....||.||.||.....|||||||||:||.:..:.|::||||
Mouse   697 ENGALDKFLREKDGEFSVLQLVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGL 761

  Fly  1085 AKLLSSDSN-EYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKD 1148
            :::|..|.. .|..:|||:||:|.|.|.|..|.|||.||||::|:.:||::|:|:||:..:...:
Mouse   762 SRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSYGIVMWEVMTYGERPYWELSNHE 826

  Fly  1149 IPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFT 1213
            :...|..|.:|..|..|...||..::.||..:.:.||.|..:.::..:..|.|        |...
Mouse   827 VMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERSRRPKFADIVSILDKLIRAP--------DSLK 883

  Fly  1214 RLPAYTSQDEKDLIRKLAPTTDGSEAI 1240
            .|..:   |.:..||  .|:|.|||.:
Mouse   884 TLADF---DPRVSIR--LPSTSGSEGV 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032	24/136 (18%)
		GF_recep_IV	572..684	CDD:464344	28/146 (19%)
		FU	662..716	CDD:214589	7/59 (12%)
		GF_recep_IV	740..>834	CDD:464344	21/109 (19%)
		PTKc_EGFR_like	930..1208	CDD:270648	99/282 (35%)
Epha2	NP_034269.2	Mediates interaction with CLDN4. /evidence=ECO:0000250	1..205		21/112 (19%)
		EphR_LBD_A2	27..200	CDD:198448	21/107 (20%)
		fn3	331..425	CDD:394996	21/140 (15%)
		fn3	439..520	CDD:394996	9/80 (11%)
		EphA2_TM	<570..611	CDD:464211	7/40 (18%)
		Mediates interaction with ARHGEF16. /evidence=ECO:0000250	607..907		108/312 (35%)
		Protein Kinases, catalytic domain	608..876	CDD:473864	96/267 (36%)
		Negatively regulates interaction with ARHGEF16. /evidence=ECO:0000250	887..977		8/24 (33%)
		SAM_EPH-A2	903..972	CDD:188942	1/3 (33%)
		PDZ-binding. /evidence=ECO:0000255	975..977