DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egfr and Egfr

DIOPT Version :9

Sequence 1:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_997538.1	Gene:	Egfr / 13649	MGIID:	95294	Length:	1210	Species:	Mus musculus

Alignment Length:	1417	Identity:	500/1417 - (35%)
Similarity:	698/1417 - (49%)	Gaps:	341/1417 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 SLEDKNKNEFVKGKICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFL 151
            :||:|        |:|.||.:||:.....|.|:.:|:..|.||..|.||||:|:: ..|.|||||
Mouse    24 ALEEK--------KVCQGTSNRLTQLGTFEDHFLSLQRMYNNCEVVLGNLEITYV-QRNYDLSFL 79

  Fly   152 DNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFV--TYSKMYT--LEIP--D 210
            ..|:||.||:||:...|:::....||||||..|:     |..|||.:  .|....|  .|:|  :
Mouse    80 KTIQEVAGYVLIALNTVERIPLENLQIIRGNALY-----ENTYALAILSNYGTNRTGLRELPMRN 139

  Fly   211 LRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHG-CWGEGP 274
            |:::|.|.|.|.||..||:|.||||.:||.|...:..:.|..:....||||..||.:| |||.|.
Mouse   140 LQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDLQSHPSSCPKCDPSCPNGSCWGGGE 204

  Fly   275 KNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMR 339
            :||||.:|:.|:.||: .||.|..|.:|||..||.|||||.:.||:.|:.|.||..||:.|||:.
Mouse   205 ENCQKLTKIICAQQCS-HRCRGRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLM 268

  Fly   340 KYNPTTYVLETNPEGKYAYGATCVKECP-GHLLRDNGACVRSCPQD--KMDKGG--ECVPCNGPC 399
            .||||||.::.||||||::||||||:|| .:::.|:|:|||:|..|  ::::.|  :|..|:|||
Mouse   269 LYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPC 333

  Fly   400 PKTCPGVTV--------LHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPE 456
            .|.|.|:.:        ::|.||..|:.||.|.|::.||...|.|     .::|..|   ||||.
Mouse   334 RKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKG-----DSFTRTP---PLDPR 390

  Fly   457 RLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLK 521
            .||:..|||||||:|.|:.....:.:|..|.|||.|.||......| :||:|..::.||.:|:||
Mouse   391 ELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQF-SLAVVGLNITSLGLRSLK 454

  Fly   522 QISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAG 586
            :||.|.|:|..||:|||.:.|.|..:...|.||..:..|.....|:....:|:..|:.:||||..
Mouse   455 EISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPE 519

  Fly   587 TDQCLTCKNFNFNGTCIADCGYISNAYK--FDNRTCKICHPECR------TCNGAGADHCQECVH 643
            ...|::|:|.:....|:..|..:....:  .:|..|..|||||.      ||.|.|.|:|.:|.|
Mouse   520 PRDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAH 584

  Fly   644 VRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKD 708
            ..||.|||..||.                 |..|..:|:
Mouse   585 YIDGPHCVKTCPA-----------------GIMGENNTL-------------------------- 606

  Fly   709 DKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETEC 773
                   .|:|.....           ||..||                :.||:
Mouse   607 -------VWKYADANN-----------VCHLCH----------------ANCTY----------- 626

  Fly   774 PADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMR 838
                                 ||.|||...|            |..|
Mouse   627 ---------------------GCAGPGLQGC------------EVWP------------------ 640

  Fly   839 HVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETV 903
                           |.|:...|...:...::||:..|:         .:....|::...:|.|:
Mouse   641 ---------------SGPKIPSIATGIVGGLLFIVVVAL---------GIGLFMRRRHIVRKRTL 681

  Fly   904 KMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPV 968
            :  ..|...|..|||.||....|...|||:|:.|.:|..|||.||||.||||:|:||||.|||||
Mouse   682 R--RLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPV 744

  Fly   969 AIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRD 1033
            |||||.::|..::::|.|.|||:||||::.::.:||.:|::|.:.|||||||.||||||||.::|
Mouse   745 AIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKD 809

  Fly  1034 KIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAA 1098
            .|||:.||||..||||||:|||::||||||||||||||:||..||||||||||||.::..||.|.
Mouse   810 NIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE 874

  Fly  1099 GGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPE 1163
            |||:||||:|||.|.:|::|.:||||::|||:|||:|||.:|::.|||.||..::|.|.:|.||.
Mouse   875 GGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPP 939

  Fly  1164 ICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTS-------Q 1221
            ||::|:|..::.||.:||..||.|::|...|::.||||.|||.|.||:...||:.|.       .
Mouse   940 ICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALM 1004

  Fly  1222 DEKDLIRKLAPTTDGSEAIAEPDDYLQPKA----APGPSHRTDCTDEIPK--------------- 1267
            ||:|:           |.:.:.|:||.|:.    :|..| ||.....:..
Mouse  1005 DEEDM-----------EDVVDADEYLIPQQGFFNSPSTS-RTPLLSSLSATSNNSTVACINRNGS 1057

  Fly  1268 --------LNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLDLPVDE----------------D 1308
                    |.||..||:   .:..:|..|.:.           |||.|                .
Mouse  1058 CRVKEDAFLQRYSSDPT---GAVTEDNIDDAF-----------LPVPEYVNQSVPKRPAGSVQNP 1108

  Fly  1309 DYLMPTCQPGPNNNNNINNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPIPT 1373
            .|......|.|..:.:..||:.|   |||                |||||..||         ||
Mouse  1109 VYHNQPLHPAPGRDLHYQNPHSN---AVG----------------NPEYLNTAQ---------PT 1145

  Fly  1374 ---QTIGIPVMGV-PGTMEVKVPMPGSE----------------PTSSDHEY 1405
               .....|.:.: .|:.::.:..|..:                ||:.:.||
Mouse  1146 CLSSGFNSPALWIQKGSHQMSLDNPDYQQDFFPKETKPNGIFKGPTAENAEY 1197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	54/127 (43%)
		GF_recep_IV	572..684	CDD:291509	36/119 (30%)
		FU	573..>606	CDD:238021	10/32 (31%)
		FU	617..659	CDD:214589	22/47 (47%)
		FU	662..716	CDD:214589	3/53 (6%)
		FU	739..786	CDD:238021	4/46 (9%)
		FU	784..834	CDD:214589	8/49 (16%)
		PTKc_EGFR_like	930..1208	CDD:270648	166/277 (60%)
		STYKc	938..1194	CDD:214568	153/255 (60%)
		Recep_L_domain	128..239	CDD:279382	51/116 (44%)
		Furin-like	253..401	CDD:279142	77/153 (50%)
		FU	255..292	CDD:214589	19/37 (51%)
		FU	302..345	CDD:238021	24/42 (57%)
Egfr	NP_997538.1	Recep_L_domain	57..168	CDD:279382	48/116 (41%)
		Approximate	75..300		107/231 (46%)
		Furin-like	184..335	CDD:279142	75/156 (48%)
		FU	231..274	CDD:238021	22/42 (52%)
		Recep_L_domain	362..481	CDD:279382	50/118 (42%)
		Approximate	390..600		81/217 (37%)
		GF_recep_IV	505..636	CDD:291509	36/138 (26%)
		FU	506..559	CDD:238021	13/54 (24%)
		FU	552..598	CDD:214589	22/51 (43%)
		TM_ErbB1	634..679	CDD:213054	5/44 (11%)
		Important for dimerization, phosphorylation and activation. /evidence=ECO:0000250	690..706		2/15 (13%)
		PTKc_EGFR	706..1018	CDD:270683	122/311 (39%)
		TyrKc	715..970	CDD:197581	86/254 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1113..1137		10/23 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	341	1.000	Domainoid score	I1078
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm42670
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5222
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.820