DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and Alk

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_031465.2 Gene:Alk / 11682 MGIID:103305 Length:1621 Species:Mus musculus


Alignment Length:135 Identity:28/135 - (20%)
Similarity:49/135 - (36%) Gaps:41/135 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 LVSFIRKVQPIVEEELSHGMTPMFDCNDNLYDASERYRVCRHQELTLRSLNPDHAVERPFYVGAA 143
            |..|.:::|.:::                    |....:|....|.|:.|||:.||         
Mouse   117 LAPFTKQLQTVLQ--------------------SNTQNLCEKLNLNLQELNPEDAV--------- 152

  Fly   144 AWLSILTRDA-PLLVVAGSPNH----AAWCDHVSSTVTVFCPKRDRYGASVQWVELSSS-PVKAC 202
                 |.::| ..:..|...:|    ||:.|..:........:||..|..: |.|:::. ..:.|
Mouse   153 -----LYQEAVQKITTALDESHQKRTAAFEDFKTKAFEAVEEERDSSGKEL-WEEVTARLGQEVC 211

  Fly   203 IESLE 207
            ..|||
Mouse   212 TFSLE 216

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032 21/86 (24%)
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032
GF_recep_IV 572..684 CDD:464344
FU 662..716 CDD:214589
GF_recep_IV 740..>834 CDD:464344
PTKc_EGFR_like 930..1208 CDD:270648
AlkNP_031465.2 Heparin-binding region. /evidence=ECO:0000250|UniProtKB:Q9UM73 48..70
MAM 270..428 CDD:99706
LDLa 445..471 CDD:197566
MAM 484..639 CDD:459878
EGF-like. /evidence=ECO:0000250|UniProtKB:Q9UM73 991..1029
FXa_inhibition 991..1025 CDD:464251
PTKc_ALK_LTK 1113..1389 CDD:270632
PHA03247 <1374..1580 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1412..1556
Blue background indicates that the domain is not in the aligned region.

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