Protein Alignment Egfr and ltk

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_002933782.3
• Gene: ltk / 100498306
• XenbaseID: XB-GENE-22068681
• Length: 1314
• Species: Xenopus tropicalis
• Alignment Length: 1539
• Identity: 303/1539 - (19%)
• Similarity: 491/1539 - (31%)
• Gaps: 533/1539 - (34%)

  Fly    24 CIWPASAARD-----------RYARQNNRQ--------RHQDIDRDRDRDRFLYRSSSAQN---- 65
            |.|.:|..||           ..|.:..|:        ||:     :|...||..|.|.:|
 Frog    63 CPWVSSIKRDGKPHWVHTVVGELASEKQRELLESQSTPRHK-----QDEILFLNTSQSTENCAVT 122

  Fly    66 ---------------------RQRGGANFAL--GLGANGVTIPTSLEDKNKNEFVKGKI------ 101
                                 .|......|:  .:.||. ::|.||::|..|:....|:
 Frog   123 WLLSPILTAGSEMCQLELVLYSQEDAIMTAMVHNIKANS-SLPLSLKEKTVNKRSNWKMLSAEIA 186

  Fly   102 --------------------------------------------CIGTKSRLSVPSNKEHHYRNL 122
                                                        |:|..| ....:....:|.||
 Frog   187 GVNEPFQISLDYIHCVQTADHPIVLESLTLRHCSAGYQDSFMPTCVGENS-FFCDNGDCINYVNL 250

  Fly   123 RDRYTN---------------------CTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISHV 166
            .| :||                     |::.||.  ..|.|.:..|.::|             :.
 Frog   251 CD-FTNDCPTGEDEGALCEIILPSGSYCSFDDGT--CGWTPYDGNDTTWL-------------YT 299

  Fly   167 DVKKV--VFPK-LQIIRGRTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLC 228
            |..::  ..|. |::::|..|: |||:.::.....|   :|:...|.:  |.|         |:|
 Frog   300 DATQIEDTSPSDLKLVKGHFLY-LSVQSKRSDGSAT---IYSAVFPKV--VTN---------NVC 349

  Fly   229 HMRTIQWSEIVS---NGTDAYYNYDFTAPERECPKCHESCTHGCWGEGPKNCQKFSKLTCSPQCA 290
            .   :.:..::|   ||:...|..:.                   |:|..:..|
 Frog   350 Q---LSFKFLISGIYNGSLGIYGLED-------------------GKGMGSSVK----------- 381

  Fly   291 GGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGK 355
                          |:...|.:|          ||::.|              |..:.:.....:
 Frog   382 --------------LWVKQGASG----------NFWNSG--------------TLQIPQFQNRFR 408

  Fly   356 YAYGATCVKECPGHLLRDNGACVRSCPQDKMDKGGECVPCNGPCPKTCPGVTVLHAGNID-SFRN 419
            ....||.......|:..||......|                           .|||.|: .:.|
 Frog   409 LLVVATWGWNSLAHIALDNVTFSVDC---------------------------FHAGRIEIGYEN 446

  Fly   420 CTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEG-THPQFRNL 483
            ..::|           .|:|........|.|...:.| ||:..|   ..|.....| |..|..|.
 Frog   447 HGLVD-----------DFEDDTVMPLSEPSYTDENSE-LELQFT---SCGASGPHGPTQTQCDNA 496

  Fly   484 SYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISS-----GSVVIQHNRDL--CYVSN 541
            ....|:..:.|::      ..|..|:  |:.:...::.|||:     |.....||...  .::|.
 Frog   497 YRSSNISVVVGKE------GPLRGVQ--LWKVPFTSVYQISAYGAAGGKGAKNHNNPAHGVFISA 553

  Fly   542 IRWPAIQKEPEQKVWVNE----------NLRADLCEKNGTICSDQCNED---------GCWGAGT 587
            | :| :||:....:.|.:          .|..::|....:|..|..::.         |..|.|.
 Frog   554 I-FP-LQKDEILYILVGQQGEDACPGKNELTKEICMGKSSIIEDNYDDQNRFSEWAGGGGGGGGA 616

  Fly   588 DQCLTCKNFNFNGTCIADCGYISNAYKFDNR-TCKICHPECRTCN---------------GAGAD 636
            .......|..|....:| .|....||..|.. .....|||....|               |.|.:
 Frog   617 SYVFKEVNGEFIPLLVA-AGGGGKAYLEDQEDPLDFIHPERFENNTAVPGPNGMSGAAGGGGGWN 680

  Fly   637 HCQE--------CVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTT---- 689
            ...|        ......||.|.....|.:::..|          |..|     |.|.||:
 Frog   681 DITELPVAGKSLLFGAEGGQTCYKAITKLQWHTSG----------GFGG-----GGGPCTSGGGG 730

  Fly   690 -----CNLAIINNDATVKRCLLKDDKCPDG-YFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCT 748
                 .|.:.:            ||...|| |...:.||..:..|.|||...
 Frog   731 GGYQGGNASEL------------DDIFTDGQYGVSFFHPSVKIFLHPLAAME------------- 770

  Fly   749 NYGYHEQV-------CSKCTHYKRREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKS 806
               .|.:|       ||.|                 |||..:|:.......|            .
 Frog   771 ---SHGEVQIKLFVNCSHC-----------------YTDNCKRDPINRSVVC------------L 803

  Fly   807 CRNFKLFDANETGPYVNSTMFNC-TSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMI 870
            |         |.|..:.|....| ..|.||..:                         .|.:::|
 Frog   804 C---------EVGTVLASDNTTCVVPKWPLAEK-------------------------QLPLSLI 834

  Fly   871 FIITGAVLVPTICILCVVTYIC--------RQKQKAKKETVKMTMA---LSGCEDSEPLRPSN-- 922
            .    |||:.|: ||.:: :.|        |:|::.:...|::...   ||....|..:...|
 Frog   835 L----AVLIATV-ILGII-FACGSLSFVYHRKKKQLEGARVRLQSTEYKLSKIRSSIIMTDYNPN 893

  Fly   923 -----IGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVP-EGENVKIPVAIKELLKSTGAES 981
                 .||:|.:|:.|....:.....||.||||.||:|:.|. .|:...:.||||.|.:....:.
 Frog   894 YCFAGKGASLSELKEVPRKNITLLRALGHGAFGEVYEGMVVGISGDPNPLQVAIKTLPEICSEQD 958

  Fly   982 SEEFLREAYIMASVEHVNLLKLLAVCMSS-QMMLITQLMPLGCLLDYVRNNRDKIGSKA------ 1039
            ..:||.||.|::...|.|:::.:.|.:.: ...::.:||..|.:..::|.||..|...:
 Frog   959 EMDFLMEALIISKFSHQNIVRCIGVSLQTLPRFILLELMSGGDMKSFLRQNRPWINQPSTLSMLD 1023

  Fly  1040 LLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQ---TPSLVKITDFGLAKLLSSDSNEYKAAGGK 1101
            |||.:..||.|..||||...:|||:||||.|:.   |..:.||.|||:|:.:...|...|.....
 Frog  1024 LLNMARDIACGCKYLEENHFIHRDIAARNCLLTYSGTGRVAKIGDFGMARDIYRASYYRKGGRAM 1088

  Fly  1102 MPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICS 1166
            :|:||:..|.....|||||:|.|:|||.:||:.:.|..|:.....:::.:.:..|.:::.|:.|.
 Frog  1089 LPVKWMPPEAFLEGVFTSKTDTWSFGVLLWEIFSLGYMPYPCKTNQEVLEFVTSGGRMDPPKNCP 1153

  Fly  1167 LDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLA 1231
            ..:|..:..||......||.|   :|:....                   :|.:|| .|:|....
 Frog  1154 GPVYRIMTQCWQHTPEHRPNF---STILERI-------------------SYCTQD-PDVINTPL 1195

  Fly  1232 PTTDGSEAIAEPDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGV 1296
            |...|.....|....::|.:..|.:.........|.|     |..:.....||...:.....:..
 Frog  1196 PVESGPAPEDEGSTSIRPNSCNGLNPIMSSQPIAPLL-----DTQSTEQKLGDVPQELLVENLAG 1255

  Fly  1297 GNLR---LDLPVDEDD------YLMPTCQPGPNNNNNINNPNQN 1331
            .|::   |....:..:      .|..|.:|.....:.:.|.::|
 Frog  1256 WNIKTPGLQTVAESTEGSWFQSNLSTTTEPKLQTTHKLKNKSKN 1299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032	23/134 (17%)
		Furin-like	253..401	CDD:395614	16/147 (11%)
		Recep_L_domain	419..547	CDD:460032	29/135 (21%)
		GF_recep_IV	572..684	CDD:464344	26/144 (18%)
		FU	662..716	CDD:214589	12/63 (19%)
		GF_recep_IV	740..>834	CDD:464344	16/101 (16%)
		PTKc_EGFR_like	930..1208	CDD:270648	88/288 (31%)
ltk	XP_002933782.3	LDLa	230..263	CDD:197566	9/34 (26%)
		MAM	277..431	CDD:99706	41/254 (16%)
		PTKc_ALK_LTK	907..1183	CDD:270632	87/297 (29%)