Protein Alignment Egfr and ephb4

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_031755496.1
• Gene: ephb4 / 100497297
• XenbaseID: XB-GENE-5881604
• Length: 945
• Species: Xenopus tropicalis
• Alignment Length: 895
• Identity: 218/895 - (24%)
• Similarity: 313/895 - (34%)
• Gaps: 279/895 - (31%)

  Fly   531 QHNRDLCYVSNIRWPAIQKEPEQKVWVN-ENLRADLC---EKNGTICSDQCN----------EDG 581
            |.|.||   :|..:|...:.|    ||. :.:.||..   .:.|:..|.:.|          .||
 Frog   116 QANHDL---ANDHFPPWMENP----WVRVDTVAADFLGRPNRRGSPGSTRLNVKTLRIGPLSGDG 173

  Fly   582 CWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHCQECVHVRD 646
            .:.|..||          |.|:|            ....::.:   |.|....|.
 Frog   174 FYLAFQDQ----------GACMA------------LLAVRVFY---RVCPAVVAS---------- 203

  Fly   647 GQHCVSECPKNKYNDRGVCRECHATC-DGCTGP---KDTI-----------GIGACTTCNLAIIN 696
                ::..||..  ..|:......:| :|..||   |.|:           .:|.| .|......
 Frog   204 ----LASFPKTV--SEGLVVSAEGSCVEGAEGPLGRKPTMYCREDGEWAKPAVGEC-ACVAGREE 261

  Fly   697 NDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCT 761
            .|...| |    ..|..|||            ||..|...|:.| |...|.|..|  ..||....
 Frog   262 KDGRTK-C----TACAPGYF------------KPTVGEKPCQPC-PANGLSTAPG--ATVCGCKP 306

  Fly   762 HYKRREQ------CETECPADHY---------TDEEQRECFQC--------HPECNGCTGPGADD 803
            .|.|...      |.|...|...         .|.|..|....        ..:|:.|.|.|  .
 Frog   307 GYYRAAMDPPTAACSTPPSAPRSIVARVNGSGVDLEWSEPLDAGGRGDLYYEVQCSECAGGG--P 369

  Fly   804 CKSCR---------------------------NFKLFDAN---------ETGPYVNSTMFN---- 828
            |..|.                           ||::...|         ..|..||.|...
 Frog   370 CIPCSRLNFTPRPQRLVDRRLRVAGLRPRVTYNFRVLALNGVSERSTSGALGEEVNVTTDRDVPL 434

  Fly   829 --------CTSKCPLEMRHVNYQYTAIGP-----------YCAASPPRS----SKITAN------ 864
                    ..|:..|.:|.....::|  |           |.|....:.    .|.|:|
 Frog   435 PVSGIQQMAASETTLTLRWATPLHSA--PTKGNILDYEVKYYAKDQEKPLIKFMKTTSNEALLAE 497

  Fly   865 --------LDVN---------------------------MIFIITGAVLVPTICILCVV--TYIC 892
                    :.|.                           .:.:|.|...|.|:.:|.|:  ..:|
 Frog   498 LLSGTVYVVQVRARTEAGYGAFSGDTLVQTLEGPEKAQPQVALIAGTAGVGTLLVLAVIVTAVVC 562

  Fly   893 RQKQKAKKETV---KMTMALSG-----------CED-SEPLRPSNIGANLCKLRIVKDAELRKGG 942
            .:|..:.||..   |....|.|           .|| :|.:|..   |....:..||..|
 Frog   563 IRKHGSSKEPEYCDKPGQYLIGHNSKVYIDPFTYEDPNEAVREF---AKEIDVSCVKIEE----- 619

  Fly   943 VLGMGAFGRVYKGVWVPEGENVKIP------VAIKELLKSTGAESSEEFLREAYIMASVEHVNLL 1001
            |:|.|.||.|.:|       .:|:|      ||||.|..........|||.||.||....|.|::
 Frog   620 VIGAGEFGEVCRG-------RLKVPGKKENYVAIKTLKGGYTERQRREFLSEASIMGQFNHPNII 677

  Fly  1002 KLLAVCMSS-QMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLA 1065
            .|..|..:: .:|:||:.|..|.|..::|.|..:.....|:.....||.||.||.|...||||||
 Frog   678 HLEGVITNNCPVMIITEYMENGALDSFLRQNDGQFTPIQLVGMLRGIASGMRYLAEMNYVHRDLA 742

  Fly  1066 ARNVLVQTPSLVKITDFGLAKLL---SSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFG 1127
            |||:||.:..:.|::||||::.|   |:|.......|||:||:|.|.|.|..|.|||.||||.:|
 Frog   743 ARNILVNSNLVCKVSDFGLSRFLQEGSTDPTYTSCLGGKIPIRWTAPEAIAFRKFTSASDVWGYG 807

  Fly  1128 VTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTT 1192
            :.:||:::||:||:.::..:|:.:.||...:|..|..|...::..:|.||..|.|:||.|..:.:
 Frog   808 IVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPAPPDCPTALHQLMLDCWQRDRALRPRFADIVS 872

  Fly  1193 VFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAE 1242
            ...:..|:|.. |.|.    ||....|||   .|:.:..|......:::|
 Frog   873 SLDKLIRNPAS-LKIT----TREQLGTSQ---PLLDQRTPHYSSFSSVSE 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032	6/15 (40%)
		GF_recep_IV	572..684	CDD:464344	22/136 (16%)
		FU	662..716	CDD:214589	15/68 (22%)
		GF_recep_IV	740..>834	CDD:464344	29/164 (18%)
		PTKc_EGFR_like	930..1208	CDD:270648	104/287 (36%)
ephb4	XP_031755496.1	EphR_LBD_B4	17..196	CDD:198442	22/111 (20%)
		FN3	<321..>548	CDD:442628	31/230 (13%)
		EphA2_TM	541..612	CDD:464211	18/73 (25%)
		PTKc_EphR_B	610..878	CDD:173638	101/279 (36%)
		SAM_superfamily	907..>945	CDD:472832	1/8 (13%)