Protein Alignment Egfr and LOC100496572

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001415012.1
• Gene: LOC100496572 / 100496572
• XenbaseID: XB-GENE-29083231
• Length: 1368
• Species: Xenopus tropicalis
• Alignment Length: 1344
• Identity: 289/1344 - (21%)
• Similarity: 458/1344 - (34%)
• Gaps: 454/1344 - (33%)

  Fly    99 GKICIGTKSRLSVPSNKEHHYRNLRDRYTN--CTYVDGNLELTWLPNENLDLSFLDNIREVTGYI 161
            |::.|..|..:......:...::.:.||.:  |.:          |...:|||..|.:.     .
 Frog   319 GELDISEKDPVLFAVFAQSEPKSAQPRYNSAVCAF----------PLRLIDLSIEDGMN-----A 368

  Fly   162 LISHVDVKKVVFPKLQIIRGRTLF--SLSVEEEKYALFVTYSKMYTLEIPDLR--DVLNGQ---- 218
            ..|:.:       .:::.||...|  .:...::......:...:.||.:|.||  |:.|||
 Frog   369 CCSNTN-------SVRLTRGLNFFQPEMDCPQKDNQSDTSCKNVPTLVLPPLRRVDIFNGQLDGV 426

  Fly   219 --------------VGF-------------HNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPER 256
                          :||             ..|.|   .||:....|..       ||..:   |
 Frog   427 LLTSVYVSPQEDLTIGFLGTSAGRLLQVVLQRNSN---PRTLSNFSISD-------NYPVS---R 478

  Fly   257 ECPKCHESCTHGCWGE-------GPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGP 314
            |..:..:|.......:       || .|:.|  ||||      ||                ...|
 Frog   479 EVTQIGDSLFFVTGNQVTKVNITGP-GCRHF--LTCS------RC----------------LRAP 518

  Fly   315 TQKDCIACKNF-FDEGVCKEEC------PPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLR 372
            ....|..|||. ..:|.|:.||      |.:..:.|.|..|.         |.|.:..|.    |
 Frog   519 RFMGCSWCKNVCCQQGECEGECAQNTCLPAITDFYPKTAPLR---------GNTNITLCG----R 570

  Fly   373 D--NGACVRSCPQDKMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFR-NCTVIDGNIRILDQTF 434
            |  :.....:.|:.|:..|...|...   |:||    :::.|..:|.. .||:         ||
 Frog   571 DFQSSVVYNAPPKAKITAGTHRVSVG---PRTC----IVNPGKSNSTSLVCTL---------QT- 618

  Fly   435 SGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLME 499
            .|..|..:.              .::..|:.|     |:.|| |.     |.:.  ||..
 Frog   619 EGLPDTAST--------------ADIALTIDE-----NLTGT-PY-----YIKG--TISA----- 651

  Fly   500 SMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRAD 564
               |....|:.::.|:| .|...::.|:::....::|           :....|:|:::    ..
 Frog   652 ---AGFNFVEPAITSIE-PNFGPLAGGTMLTLKGQNL-----------RSGETQRVFIS----GA 697

  Fly   565 LCEKNGTICSDQ--CNEDGCWGAGTDQCLTCKNFN---FNGTCIADCGYISNAYKFDNR---TCK 621
            .|..:|::|..:  |            |::.::.:   .|.:.:.|...||:..:|..:   ...
 Frog   698 ECMISGSLCPAEVLC------------CVSPRSLSLGPLNVSALLDGAEISSPAQFQYKPDPLVS 750

  Fly   622 ICHPECR-------TCNGAGADHCQECVHVRDGQHCV-SECPKNKYNDRGVCRECHATCDGCTGP 678
            :..|.|.       |..|:..|..........||..| |:|.....:||.|||.......|..|
 Frog   751 VIRPNCSLASGTRLTIQGSNLDSVSSIKISYSGQKTVSSDCQGTFSSDRIVCRSPEYPYFGRPG- 814

  Fly   679 KDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEY---------VHP-----QEQGSLK 729
                      ...||:   ||.             .|.:.|         :||     .:.|.||
 Frog   815 ----------NLTLAL---DAV-------------NYIYPYRFRYLQNYVIHPFRPKDPDGGILK 853

  Fly   730 PLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPECN 794
            ...|.....                      ||.:..||..|              |.:......
 Frog   854 LKKGEDEIE----------------------THQENLEQVAT--------------CLKVSMTVG 882

  Fly   795 GCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSS 859
            |                    .|..|.|......|  :.|..|               ..|...|
 Frog   883 G--------------------RECNPTVLKNEITC--RIPKGM---------------VIPSEGS 910

  Fly   860 KITANLD-----------VNMIFIITGAVL--VPTICILCVVTYIC--RQKQKAKKETVKMTMAL 909
            .:...:|           |||:..:.|.||  |.::.::.|:.::.  .|::|.||..|:....|
 Frog   911 IVQVCVDDDCTTVGLVMIVNMLDPVLGIVLGSVASVLVVAVLIFLLLKHQRKKKKKPAVEALELL 975

  Fly   910 SGCEDSEPLRP---------------SNIGANLCK-----------------------------L 930
            |.......|.|               ||.|..|..                             |
 Frog   976 SNNNREPVLSPISLLHVDYRTSYIPSSNSGGMLSHGAGYSGGSLGGGSMPILLTSLLDSLRPELL 1040

  Fly   931 RIVKDAEL-------RKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLRE 988
            ..|||..:       .:..::|.|.||.||.|.:|.|.:. ::..|:|.|.:.|..|..||||||
 Frog  1041 EEVKDVLIPERCLTTHRDRIIGKGHFGSVYHGTYVDEDQQ-EVHCAVKSLNRITDLEEVEEFLRE 1104

  Fly   989 AYIMASVEHVNLLKLLAVCMSSQ--MMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGM 1051
            ..:|.|..|.|:|.|:.:.:..:  .:::...|..|.|..::|........|.|:.:..|:::||
 Frog  1105 GILMKSFHHPNVLSLIGIFLPQEGLPLVVLPFMKHGDLRHFIRCQERNPTVKDLVGFGLQVSRGM 1169

  Fly  1052 SYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEY---KAAGGKMPIKWLALECIR 1113
            .||..::.|||||||||.::.....||:.|||||:.: .|...|   :....::|:||:|||.::
 Frog  1170 EYLANRKFVHRDLAARNCMLDETFHVKVADFGLARDV-FDKEYYSVRRHKNARLPVKWMALESLQ 1233

  Fly  1114 NRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWH 1178
            .:.||:|||||:|||.:|||:|.|..|:.::...||...:..|.:|.|||.|...:|..:||||:
 Frog  1234 TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVDPYDITRYLFRGRRLAQPEYCPDPLYSLMLSCWN 1298

  Fly  1179 LDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRL-PAYTSQDEKDLIRKLAPTTDGSEAIAE 1242
            .....||||.||.......:.      ::.||.:..| ..|.:.|..   :...||...||
 Frog  1299 PQPEERPTFTQLVGDMEVISN------SLCGDHYINLNVTYVNLDRD---QPFPPTHPPSE---- 1350

  Fly  1243 PDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDE 1286
                                ||:          ..:||||.::|
 Frog  1351 --------------------DEL----------EEENSSTEEEE 1364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032	25/147 (17%)
		Furin-like	253..401	CDD:395614	35/163 (21%)
		Recep_L_domain	419..547	CDD:460032	22/127 (17%)
		GF_recep_IV	572..684	CDD:464344	25/127 (20%)
		FU	662..716	CDD:214589	10/53 (19%)
		GF_recep_IV	740..>834	CDD:464344	11/93 (12%)
		PTKc_EGFR_like	930..1208	CDD:270648	100/289 (35%)
LOC100496572	NP_001415012.1	None