DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and ntrk1

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_002939035.2 Gene:ntrk1 / 100489637 XenbaseID:XB-GENE-923001 Length:808 Species:Xenopus tropicalis


Alignment Length:920 Identity:200/920 - (21%)
Similarity:343/920 - (37%) Gaps:243/920 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   378 VRSCPQDKMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYA 442
            |.||| |.....|..|.|..  |.|...:.:|  |.:::... .||:....:|..|    :|...
 Frog    40 VNSCP-DTCRCYGTLVQCLE--PNTISSIFIL--GEMENITE-IVIENQKDLLSLT----RDDMK 94

  Fly   443 NYTMGPRYIPLDPERLEVFST----VKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFA 503
            |:.        :.:.|.:.||    :.|....:|...||   .|||                   
 Frog    95 NFR--------ELKNLTISSTGLEYISEDAFEMNPRMTH---INLS------------------- 129

  Fly   504 ALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKE--------PEQKVWVN-- 558
                 .:||.|...|....:....:::..|...| ...|||..:::|        .....|.:  
 Frog   130 -----SNSLVSASWRTFLNLPLQELILTGNPFRC-SCEIRWLQLKREIDWADLGNQSLSCWADTF 188

  Fly   559 ENLRADL----CE--------KNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISN 611
            |.|..|:    ||        :|.|:..           |.:..|.|   |.:|.......:|  
 Frog   189 EILLEDMIISNCELPQVSIVKQNLTVLE-----------GANLTLVC---NVDGQPTPTATWI-- 237

  Fly   612 AYKFDNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGV-CRECHATCDGC 675
            ..:.|:.|      |....||:..:......::..|           :|.|.| ||     .:..
 Frog   238 VPEMDSYT------EIGQSNGSETEIFLPLFNISPG-----------FNKRNVTCR-----AENM 280

  Fly   676 TGP-KDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYF-WEYVHPQEQGSLKPLAGRAVCR 738
            .|| ::.:.|.......:..:            ::..|..:| :.|.   ..|:.||        
 Frog   281 VGPSEEHVQINVLFPAMVVAL------------EEAIPQHHFCFPYT---VDGNPKP-------- 322

  Fly   739 KCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADD 803
                  |:...:..|....:...:.|              |.||.......|    ||.......
 Frog   323 ------EIRWQFNGHNLEMNDYIYLK--------------TVEESENSTAIH----GCLYLNKPT 363

  Fly   804 CKSCRNFKLF------DANET--GPYV-NSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSS 859
            ..:..|:.:.      .|:||  ..:: |...||.....|:.:                ||....
 Frog   364 HVNNGNYTILVWNMLGSASETVYSKFMDNPFSFNPEEPIPVSL----------------SPEGGG 412

  Fly   860 KITANLDVNMI----FIITGAV-LVPTICILCVVTYI----CRQKQK---------AKKETVKM- 905
            ..|....|..:    |.::.|| |....|:..::..|    |.:..|         |:::.:.| 
 Frog   413 NSTYTTTVETVEENTFGVSVAVGLAVFACLFLLLILIALNKCGRHSKFGINRAAVLAQEDDLAMS 477

  Fly   906 -------TMALSGCEDS-EPLRPSNIG-----ANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVW 957
                   |..|:..|.. :.::|:.|.     .:.| ::.:|..::.....||.||||:|:...:
 Frog   478 LHFMNFGTSPLTSAEGKLDGMKPNFIENPQYFCDAC-VQHIKRRDIVLKWELGEGAFGKVFLAEF 541

  Fly   958 ---VPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQ-MMLITQL 1018
               .||.|  |..||:|.|.::| ..:.::|.|||.::..::|.:::|...||...: ::::.:.
 Frog   542 YNLTPENE--KTLVAVKALKEAT-ENARQDFQREAELLTVLQHEHIVKFYGVCTDGEPLIMVFEY 603

  Fly  1019 MPLGCLLDYVRNN--------------RDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNV 1069
            |..|.|..::|::              ..::....:|..::|||.||.||.....||||||.||.
 Frog   604 MKHGDLNRFLRSHGPDAKILDNGNGQPYGQLNLTQMLQIASQIASGMVYLASLHFVHRDLATRNC 668

  Fly  1070 LVQTPSLVKITDFGLAKLLSSDSNEYKAAGGK--MPIKWLALECIRNRVFTSKSDVWAFGVTIWE 1132
            ||....:|||.|||:::.:.  |.:|...||:  :||:|:..|.|..|.||::||:|:|||.:||
 Frog   669 LVGNNLVVKIGDFGMSRDIY--STDYYRVGGRTMLPIRWMPPESILYRKFTTESDIWSFGVVLWE 731

  Fly  1133 LLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEF 1197
            :.|:|::|...:...:..:.|..|.:||:|..|..::|..:..||..:...|...|::.......
 Frog   732 IFTYGKQPWYQLSNTEAIECITQGRQLERPRTCPTEVYNIMQGCWQREPQQRLNIKEIHNKLQAL 796

  Fly  1198 ARDPGRYLAI 1207
            .:.|..||.|
 Frog   797 VKAPPVYLDI 806

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614 8/22 (36%)
Recep_L_domain 419..547 CDD:460032 25/131 (19%)
GF_recep_IV 572..684 CDD:464344 19/113 (17%)
FU 662..716 CDD:214589 8/55 (15%)
GF_recep_IV 740..>834 CDD:464344 16/102 (16%)
PTKc_EGFR_like 930..1208 CDD:270648 91/298 (31%)
ntrk1XP_002939035.2 LRR_8 97..156 CDD:404697 15/93 (16%)
leucine-rich repeat 99..122 CDD:275378 5/22 (23%)
leucine-rich repeat 123..145 CDD:275378 9/48 (19%)
LRRCT_2 157..201 CDD:465313 9/44 (20%)
Ig 211..292 CDD:472250 22/118 (19%)
Ig strand B 220..224 CDD:409353 1/3 (33%)
Ig strand C 233..237 CDD:409353 0/3 (0%)
Ig strand E 257..261 CDD:409353 0/3 (0%)
Ig strand F 272..277 CDD:409353 3/9 (33%)
Ig strand G 285..288 CDD:409353 0/2 (0%)
Ig 295..390 CDD:472250 19/141 (13%)
Ig strand B 310..314 CDD:409353 1/3 (33%)
Ig strand C 323..327 CDD:409353 1/3 (33%)
Ig strand E 355..359 CDD:409353 2/3 (67%)
Ig strand F 369..374 CDD:409353 1/4 (25%)
Ig strand G 382..385 CDD:409353 1/2 (50%)
PTKc_TrkA 516..795 CDD:270674 87/283 (31%)
Blue background indicates that the domain is not in the aligned region.

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