DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and fras1

DIOPT Version :9

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_002935497.2 Gene:fras1 / 100487299 XenbaseID:XB-GENE-478807 Length:4014 Species:Xenopus tropicalis


Alignment Length:1304 Identity:253/1304 - (19%)
Similarity:392/1304 - (30%) Gaps:512/1304 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   233 IQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHG-----CWGEGPKNCQKFSKL----TCSPQ 288
            :|....|.|....:|....|.  :||.|...||.:|     |.|         |.|    .|.|.
 Frog   455 LQKGHCVVNCGSGFYQDGKTC--QECKKSCSSCKNGLECTSCVG---------SLLLKHGQCVPT 508

  Fly   289 CAGGRCYGPKPREC--CHLFCAGGCTGPTQKDCIACKNFFD---EGVCKEECPP---MRKYNPTT 345
            |..|  |..:...|  ||..|: .|.|.::.||:.|::...   .|.|...|..   ||  |.|.
 Frog   509 CGDG--YYKQHHHCEACHESCS-VCHGASEGDCVTCRDPSQVNIGGKCISNCGHGFYMR--NGTC 568

  Fly   346 YVLET-----NPEG---------KYAYGATCVKECPGHLLRDNGACVRSCPQDKMDKGGECVPCN 396
            .|.::     :|:|         |:..| |||.||||....|:.|...:|.:       ||..|:
 Frog   569 AVCDSTCQSCSPDGRCFTCANGRKFHRG-TCVLECPGGYYADSSALCTACHR-------ECASCS 625

  Fly   397 GPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVF 461
            ||....|              .:|                                |.|      
 Frog   626 GPLANHC--------------TSC--------------------------------LPP------ 638

  Fly   462 STVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLM---ESMFAALAIVKSSLYSLEMRNLKQI 523
                                       |..:.|:.|:   |..|:                    
 Frog   639 ---------------------------LGLLKGQCLLDCGEGFFS-------------------- 656

  Fly   524 SSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTD 588
                     ::.:|                                 |.|...|.  .|.|....
 Frog   657 ---------DKSVC---------------------------------TACHPSCR--ACLGPEHS 677

  Fly   589 QCLTCKNFNFN------------GTCIADCGYISNAYKFDNRT--CKICHPECRTCNGAGADHCQ 639
            .|..|.|....            |||...|    |.|.:.:..  |:.|||.|::|:|....:|.
 Frog   678 HCTKCINPEQGLQVVQEYAGKPYGTCQTHC----NLYFYMDSVGICRDCHPSCKSCSGEDKSNCT 738

  Fly   640 EC--VHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVK 702
            .|  .:|..|..|:..||...||....|..||.:|..|:||.|    ..|.||:...:..|.   
 Frog   739 SCPSQYVLHGGVCLQRCPDGYYNKESTCYTCHPSCKECSGPSD----ADCQTCHPHAVLTDG--- 796

  Fly   703 RCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELC-TNYGYHEQVCSKC---THY 763
            ||   ...|.||.:...|              ..|..|||.|:.| .|......||.||   .:|
 Frog   797 RC---KTHCADGQYLNLV--------------GYCVDCHPQCQYCVANLQDTGSVCLKCQYSRYY 844

  Fly   764 KRREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANE-------TGPY 821
            ...::|.:||||..|||  .|.|.:|:..|..|:||..|.|.||.:..:...|.       .|.|
 Frog   845 FIEDRCVSECPAGFYTD--GRSCKRCNHSCKTCSGPWMDSCTSCEDGLILSHNGMCVQSCFQGYY 907

  Fly   822 --------VNSTMFNCTS----------------------------------------------- 831
                    .||....|.|                                               
 Frog   908 RAGQVCKACNSQCLTCDSASSCTSCKDPSKVLLFGECQYESCTQQYYLDYTSGTCKECDWSCNAC 972

  Fly   832 KCPLE------MRHVNYQYTAIGPYCAASPPR------------------SSKITANLDVNMIFI 872
            |.||:      |.|......|...:|   ||.                  |............::
 Frog   973 KGPLKNDCLQCMEHYALHAGACVEHC---PPAFYKHGETCRECGEHCRVCSGPFQCTQCETPFYL 1034

  Fly   873 ITGAVL-----------VPTICILCVVTYI-CRQKQKA----KKETVKMTMALSGCEDSEPLRPS 921
            :.|..:           |..:|::|....: |.:.::.    :|..:|..:.:|.|.......|.
 Frog  1035 LDGQCVSECGKQHRISQVGRLCLVCPPGCLDCDESKRCNLCDRKTYLKNHLCVSHCGTDFSGNPI 1099

  Fly   922 NIGANLCKLRIVKDAELRKGGV-LGMGAFGRV---YKGVWVPEGENVKIPVAI------------ 970
            |   ..|::.:.....:..|.: :|:||...:   :..|...:.||:.:...:            
 Frog  1100 N---RRCEVNVHAPVLVVNGSLTVGIGAARSLDFSFMNVKDQDNENISLMFHVVNVPTNGRLVKF 1161

  Fly   971 ---KELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNR 1032
               ||:........|.|.|:|..:                                   |.::||
 Frog  1162 LDGKEIHLYKDTHFSWEDLKEKRV-----------------------------------YFKHNR 1191

  Fly  1033 DKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVK----ITDFGLAKLLSS--- 1090
            ||..:..   ::.:::.|..:.:.:.:   |:.|  |..:.|.::|    :...|.|:.:||   
 Frog  1192 DKPRNGV---FALKVSDGQLFSQPENI---DIQA--VSTKAPYILKDEVLVVARGEAETISSSVL 1248

  Fly  1091 ----DSN---------EYKAAG------GKMPIKWLALECIRNRVF-------TSKSDV------ 1123
                |.|         |....|      ||.......|:.|||.:.       .|.|||      
 Frog  1249 DLQDDDNAQDVVLTVLESPKNGQVVILPGKSSAHKFRLDDIRNGIIHYIHDGSDSHSDVILFQAS 1313

  Fly  1124 -------WAFGVTIWELLTFGQRPHENIPAKDIPD--LIEVGLKLEQPEI--CSLDIYCTLLSCW 1177
                   :.|.:.|.|..:.|.:...|.|.. :|:  ::::..||.|...  .|.:|..|::.  
 Frog  1314 DGYHFLNFLFRLKITEKQSKGLQLVLNSPLW-LPEGGMLQISNKLLQARASGSSNEIIYTIID-- 1375

  Fly  1178 HLDAAMRPTFKQLTTVFAEFARDPGR-YLAIP-GDKFTRLPAYTSQD-EKDLI--RKLAPTTDGS 1237
                 ..|.|..:..:....|..|.. :..:| |...|:..::|.|| .:.|:  |:....:.|.
 Frog  1376 -----ELPRFGDVVLLVPMPADGPANGWQRLPDGRVATQTSSFTQQDINEGLVWYRQSGSHSQGK 1435

  Fly  1238 EAIA---------------------EPDDYLQPKAAPGPS-HRTDCTDEIPKLNRY------CKD 1274
            ::..                     .|:....|:.:||.| |.|...|.:..:..:      .:.
 Frog  1436 DSFTFQISSATSQTPQDSHVFSIGIVPNHPGAPQLSPGSSLHMTALEDRLTVIGSHYLSFVDAES 1500

  Fly  1275 PSNK 1278
            ||.|
 Frog  1501 PSEK 1504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382 9/130 (7%)
GF_recep_IV 572..684 CDD:291509 37/127 (29%)
FU 573..>606 CDD:238021 10/44 (23%)
FU 617..659 CDD:214589 14/45 (31%)
FU 662..716 CDD:214589 17/53 (32%)
FU 739..786 CDD:238021 20/50 (40%)
FU 784..834 CDD:214589 19/111 (17%)
PTKc_EGFR_like 930..1208 CDD:270648 59/347 (17%)
STYKc 938..1194 CDD:214568 57/324 (18%)
Recep_L_domain 128..239 CDD:279382 1/5 (20%)
Furin-like 253..401 CDD:279142 51/178 (29%)
FU 255..292 CDD:214589 13/45 (29%)
FU 302..345 CDD:238021 15/50 (30%)
fras1XP_002935497.2 VWC 37..96 CDD:278520
VWC 104..161 CDD:278520
VWC 168..225 CDD:278520
VWC 230..287 CDD:278520
VWC 294..351 CDD:327433
VWC 380..426 CDD:214564
VSP 406..789 CDD:146106 107/508 (21%)
VSP 649..1031 CDD:146106 99/478 (21%)
FU 1011..1057 CDD:238021 3/45 (7%)
Cadherin_3 1105..1206 CDD:374418 18/138 (13%)
Cadherin_3 1210..1315 CDD:374418 23/109 (21%)
Cadherin_3 1321..1443 CDD:374418 26/129 (20%)
Cadherin_3 1450..1578 CDD:374418 11/55 (20%)
Cadherin_3 1597..1695 CDD:374418
Cadherin_3 1697..1814 CDD:374418
Cadherin_3 1821..1942 CDD:374418
Cadherin_3 1945..2063 CDD:374418
Cadherin_3 2071..2182 CDD:374418
Cadherin_3 2189..2297 CDD:374418
Cadherin_3 2301..2410 CDD:374418
Cadherin_3 2429..2541 CDD:374418
caca <2557..>2807 CDD:273296
Calx-beta 2557..2654 CDD:367364
caca <2800..>3051 CDD:273296
Calx-beta 3043..3137 CDD:383005
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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