Protein Alignment Egfr and epha7

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_031758138.1
• Gene: epha7 / 100486526
• XenbaseID: XB-GENE-488635
• Length: 1062
• Species: Xenopus tropicalis
• Alignment Length: 1150
• Identity: 231/1150 - (20%)
• Similarity: 382/1150 - (33%)
• Gaps: 417/1150 - (36%)

  Fly   410 HAGNIDSFRNCTVIDG-----NIRILDQTFSGFQDVYA---NYTMGPRY---IPLDPER------ 457
            |.|...|.:...::|.     .:..:.....|::::..   |||....|   ..|:|.:
 Frog    22 HTGEAQSAKEVILLDSKAQQTELEWISSPSGGWEEISGLDENYTPIRTYQVCQVLEPNQNNWLRT 86

  Fly   458 ------------LEVFSTVKEITGYLNIEGTHPQFRNLSYFR-NLETIHGRQLMESMFAALAIV- 508
                        :|:..|:::......:.||..:..||.|:. :.||  ||.:.|:.:..:..:
 Frog    87 NWISKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYET--GRNMRENQYVKIDTIA 149

  Fly   509 ------------KSSLYSLEMRNLKQISS----------GSVVIQHNRDLCYVSNIRWPAIQKEP 551
                        :....:.|:|.:..:|.          |:.:...:..:.|
 Frog   150 ADESFTQGDLGERKMKLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYY------------- 201

  Fly   552 EQKVW-VNENLR-----------ADLCEKNGTICSD-----------QCNEDGCWGAGTDQCLTC 593
             :|.| :.|||.           :.|.|..||..::           .|:.:|.|....
 Frog   202 -KKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVTNAEEEADNSPRMHCSAEGEWLVPI------ 259

  Fly   594 KNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNGAG----ADHCQECVHVRDGQHCVSEC 654
                  |.||...||   ..|.|  ||:.|        |.|    :....:|          |.|
 Frog   260 ------GKCICQAGY---QQKGD--TCEPC--------GRGFYKSSSQDLQC----------SRC 295

  Fly   655 PKNKYNDRGVCRECHATCD---------------GCTGPKDTIGIGACTTCNLAIINNDATVKRC 704
            |.:.::|    :|..:.||               .||.|..       ...||....|..||.
 Frog   296 PAHSFSD----KEGSSRCDCEDGYYRAFSDPPYIACTRPPS-------APQNLIYNINQTTVS-- 347

  Fly   705 LLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKC---HPLCELCTN-YGY------------- 752
                        .|:..|.:.|....:..|.||::|   ...|..|.| .||
 Frog   348 ------------LEWSPPADNGGRSDVTYRVVCKRCSWEQGECIPCANTIGYVPQQSGLVDTYIS 400

  Fly   753 -----------------------------------------HEQVCSKCTHYKRRE-----QCET 771
                                                     :::..|:...|....     |...
 Frog   401 IVDLVAHANYTFEVEAVNGVSDLSRSQRLFAAVSVTTGQAVYKEGLSRSMQYGNHPSYVEMQISG 465

  Fly   772 ECPA----------------------DH-----------YTDEEQRECFQCHPECNGCTGPGADD 803
            |.|:                      :|           |.:::|||
 Frog   466 EAPSQVSGVMKERVLQRAVDLSWQEPEHPNGVITEYEIKYYEKDQRE------------------ 512

  Fly   804 CKSCRNFKLFDANETGPYVNST------MFNCTSKCPLEMRHVNYQYTAIGPYCAASP------- 855
                |.:.......|...:|:.      :|...:            :||.| |...||
 Frog   513 ----RTYSTLKTKSTSVSINNLRPGTAYIFQIRA------------FTAAG-YGMYSPRLDVSTL 560

  Fly   856 PRSSKITANLDVNMIFIITGAVLVPTICILCVV-TYICRQK----QKAKK---ETVKMTMALSGC 912
            ..::....:.:.|.:.||....:..||.::.:| .:|..::    .||.:   |.:.......|.
 Frog   561 EEATATAVSTEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFKFPGT 625

  Fly   913 E---DSEPLRPSNIGANLCKLRIVKDAE---LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIK 971
            :   |.|.....|...:    :..|:.:   ::...|:|.|.||.|..|.....|:. .:|||||
 Frog   626 KTYIDPETYEDPNRAVH----QFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKR-DVPVAIK 685

  Fly   972 ELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRDKI 1035
            .|......:...:||.||.||...:|.|::.|..|....: :|::.:.|..|.|..::|..:.|
 Frog   686 TLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRQQQKK- 749

  Fly  1036 GSKALLNW-----------STQ-----------------------------------IAKGMSYL 1054
             .|..|.|           |||                                   ||.||.||
 Frog   750 -GKNCLEWFTSPPKSKRSGSTQTMPFVKVQTLNTPGTNAQKLDGQFTVIQLVGMLRGIAAGMRYL 813

  Fly  1055 EEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNE-YKAAGGKMPIKWLALECIRNRVFT 1118
            .:...|||||||||:||.:..:.|::||||::::..|.:. |...|||:|::|.|.|.|:.|.||
 Frog   814 ADMGYVHRDLAARNILVNSNLVCKVSDFGLSRIIEDDPDAVYTTTGGKIPVRWTAPEAIQYRKFT 878

  Fly  1119 SKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAM 1183
            |.||||::|:.:||::::|:||:.::..:|:...||.|.:|..|..|...::..:|.||..:...
 Frog   879 SASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERGE 943

  Fly  1184 RPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDL-IRKLAPTTDGSEAIAEPDDYL 1247
            ||.|:|:..:..:..|:|.. |..|.....| |.....|:..| ........:..|||
 Frog   944 RPKFEQIVGILDKMIRNPNS-LKTPMGTCNR-PTSPLLDQNTLDFNSFCSVGEWLEAI------- 999

  Fly  1248 QPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDETDSSAR 1292
                               |:.||    ....||:|.:..:|.||
 Frog  1000 -------------------KMERY----KENFSSSGYNSLESVAR 1021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032	25/180 (14%)
		GF_recep_IV	572..684	CDD:464344	26/141 (18%)
		FU	662..716	CDD:214589	11/68 (16%)
		GF_recep_IV	740..>834	CDD:464344	20/195 (10%)
		PTKc_EGFR_like	930..1208	CDD:270648	100/328 (30%)
epha7	XP_031758138.1	EphR_LBD_A7	29..205	CDD:198453	26/191 (14%)
		Ephrin_rec_like	274..311	CDD:429604	12/58 (21%)
		FN3	<328..>574	CDD:442628	39/301 (13%)
		FN3	468..559	CDD:238020	16/125 (13%)
		EphA2_TM	585..650	CDD:464211	12/68 (18%)
		PTKc_EphR_A	648..958	CDD:270651	96/312 (31%)
		SAM_EPH-A7	983..1052	CDD:188947	12/68 (18%)