Protein Alignment Egfr and mst1rb

DIOPT Version :10

• Sequence 1: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_073773053.1
• Gene: mst1rb / 100134855
• ZFINID: ZDB-GENE-071218-3
• Length: 1374
• Species: Danio rerio
• Alignment Length: 1364
• Identity: 290/1364 - (21%)
• Similarity: 464/1364 - (34%)
• Gaps: 469/1364 - (34%)

  Fly    34 RYARQNNRQRHQDIDRDRDRDRFLYRSSSAQNRQRGGANFALGLGA----------------NGV 82
            |..|.|..:..:|:         :|....|.:..:.|...|..|||                :||
Zfish   296 RRRRSNVSEPFKDV---------VYNVVQAAHFGKAGRELADELGAEEEDDILYGVFAVTDDSGV 351

  Fly    83 -------------TIPTSLED------KNKNEFVKGKICIGTKSRLSVPSNKEHHYRNLRDRYTN 128
                         |:.|:::|      |:..|.:...:|...... |.|.....|....||..|
Zfish   352 PEHDSALCAFPMDTVNTAIDDGVEDCCKSGPEQLSRGLCHFQPCE-SCPHESMEHNMTCRDHPT- 414

  Fly   129 CTYVDGNLELTWLPNENLDLSFLDNIREV-TGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEE 192
                     |...|...:|| |...:|.| ...:|::.::.|.|.  .:....|| |..|.:...
Zfish   415 ---------LVAQPYYRVDL-FNRQMRGVLLTSLLVTSIENKTVA--HIGTSDGR-LLQLVLRRS 466

  Fly   193 KYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERE 257
            ...:|..||.:...::.....||:..          |:..:...:::            ..|:|
Zfish   467 SPIIFANYSLVENQKVSSTAAVLSQN----------HLLFVVGDKMI------------RVPQR- 508

  Fly   258 CPKCHESCTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIAC 322
                           || .|:.|  |||: .|    ...||...|.  :|:|.||..::     |
Zfish   509 ---------------GP-GCRHF--LTCA-MC----LTAPKFMGCG--WCSGQCTWASE-----C 543

  Fly   323 KNFFDEGVCKEECPP-MRKYNPTTYVLETNPEG------------------------KYAYGAT- 361
            :..:    ..|.||| :.::.|.|    ..|:|                        :...|.|
Zfish   544 RAHW----VNESCPPVITEFFPKT----APPDGQSEMTLCGWEFQSPLRPAITTRTHEVRLGETA 600

  Fly   362 CV-----KECPGHLLRDNGAC-VRSCPQDKMDKGGECVPCNGPCPKTCPGVTV-LHAGNIDSFRN 419
            ||     ..|. |||     | :||...:.:.|     |.|         ||. :|.|.::...:
Zfish   601 CVVQPHKSNCT-HLL-----CKIRSGTIETLFK-----PLN---------VTAKVHEGQVEGHYS 645

  Fly   420 CTVIDGNIRILDQTFSGFQDVYANYT-MGPRYIPLDPERLEVFSTVKEITG-YLNIEGTHPQFRN 482
               |||:..:     .||..|..|.| :.|.|.|:|.      .|:..||| ||:
Zfish   646 ---IDGSAEM-----PGFTFVVPNITEVQPDYGPVDG------GTLITITGPYLD---------- 686

  Fly   483 LSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAI 547
                      .|:....::......|:|  .|:...||..|...|..:...:|:..
Zfish   687 ----------SGKNRKVTLDGESCPVQS--VSVARGNLSSIVCLSQPVTEVKDVVL--------- 730

  Fly   548 QKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGT-----CIADCG 607
                  :|:::::                            :.:|.|.|.:..|     .:.||.
Zfish   731 ------RVYIDKS----------------------------RVVTTKVFRYKKTPEILAVLPDCS 761

  Fly   608 Y------ISNAYKFDN--RTC-----KICH--PECRTCNGAGADHCQECVHVRDGQHCVSECPKN 657
            :      |......|:  ||.     |..|  |....|.|.......||:        ....|::
Zfish   762 FDSGSRIIIEGRNLDSVYRTVVYFQPKESHLKPVSTECRGKAKPTRMECI--------TPVFPRD 818

  Fly   658 KYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHP 722
            : .:.|   |.....||..|                                      .|::
Zfish   819 E-TEEG---ELSFDMDGVLG--------------------------------------LWKH--- 838

  Fly   723 QEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETE------CPA-DHYTD 780
                                      ::.||.        |.|....|||      .|. |..:.
Zfish   839 --------------------------DFSYHP--------YGRPIPFETEGHILRLYPGFDEVSL 869

  Fly   781 EEQRECFQCHPECNGCTGPGAD-DCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQY 844
            ..|:  ......|...|....| ||..    |:.| ||....:.:.:...:...|:::....|.:
Zfish   870 HHQK--LNLVSSCMSITMTVGDVDCGG----KVLD-NEITCRIPNNLTIPSEGLPVKVTVNGYTH 927

  Fly   845 TAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKET------- 902
            . :|.....|......|...:   :..::|||||.     ..|:..:.:||:.::.|.
Zfish   928 N-VGTVILVSNHYMVGIVLGI---LAALVTGAVLA-----FIVLKNLRKQKKASQTENRLSYFSH 983

  Fly   903 -------------------VKMT-------------MALSGCEDS--EPLR-PSNIGANLCK--- 929
                               :.:|             :|.:|..|:  .||. |.||.....:
Zfish   984 SRSRSNSVDLSSLVDYRRDLPLTSITAPTGALAFPGLAYTGTLDTTLTPLMPPENISITSFRPEL 1048

  Fly   930 LRIVKDA-------ELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLR 987
            |..|||.       ::....::|.|.||.||.| ::.:..|.:|..|:|.|.:.|..|..|:||:
Zfish  1049 LEEVKDVLIPASTLKVHHHQIIGKGHFGTVYHG-YLTDHNNREIHCAVKSLNRITDVEEVEQFLK 1112

  Fly   988 EAYIMASVEHVNLLKLLAVCMSSQ--MMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKG 1050
            |..:|....|.|:|.||.:.:..:  .:::...|..|.|..::|........|.|:.:..|:|||
Zfish  1113 EGILMKGFHHSNVLSLLGILLPEEGLPLVVLPYMKHGDLRHFIRCENRNPTVKDLIGFGLQVAKG 1177

  Fly  1051 MSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLA-----KLLSSDSNEYKAAGGKMPIKWLALE 1110
            |.||.:|:.|||||||||.::.....||:.|||:|     |...|..:..||   |:|:||:|:|
Zfish  1178 MEYLAQKKFVHRDLAARNCMLDESYTVKVADFGMARDVLEKEYYSVQDHRKA---KLPVKWMAIE 1239

  Fly  1111 CIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLS 1175
            .::.:.||:|||||:|||.:||:||.|..|:..:...|:...:..|.:|.||:.|...::..||.
Zfish  1240 SLQTQKFTTKSDVWSFGVLMWEMLTRGASPYPEVDPYDVTHFLLKGRRLPQPQYCPDPLFAILLQ 1304

  Fly  1176 CWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRL-------------PAYT-SQDEKD 1225
            ||..|...||:|..|.:.......      ::.|:.:..|             ||.| |.||.|
Zfish  1305 CWDPDPEKRPSFSTLVSAVMSILS------SLEGEHYISLKVTYVNLDQPRPYPALTDSADEYD 1362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032	20/111 (18%)
		Furin-like	253..401	CDD:395614	40/179 (22%)
		Recep_L_domain	419..547	CDD:460032	27/129 (21%)
		GF_recep_IV	572..684	CDD:464344	23/131 (18%)
		FU	662..716	CDD:214589	5/53 (9%)
		GF_recep_IV	740..>834	CDD:464344	19/101 (19%)
		PTKc_EGFR_like	930..1208	CDD:270648	98/291 (34%)
mst1rb	XP_073773053.1	None