DRSC/TRiP Functional Genomics Resources

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Protein Alignment Egfr and fgfr4

DIOPT Version :10

Sequence 1:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster
Sequence 2:XP_068071845.2 Gene:fgfr4 / 100000160 ZFINID:ZDB-GENE-980526-488 Length:923 Species:Danio rerio


Alignment Length:581 Identity:140/581 - (24%)
Similarity:238/581 - (40%) Gaps:148/581 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   778 YTDEEQRECFQCHPECNGCT-GP-GADDCKSCR---------------NFKLFDANETGPYVNST 825
            |:|.:....:..|.|.||.. || |....|..:               |..:.||.|        
Zfish   386 YSDAQPHIQWLKHIEMNGSRYGPDGIPYVKIVKTGSLNMSEVEVLYLTNISMEDAGE-------- 442

  Fly   826 MFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDV-----NMIFIITGAVLVPTICIL 885
             :.|.:...:...|.:...|.:.         ...:...:|:     ..|.|.....|...:.|:
Zfish   443 -YTCLAGNSIGFSHQSAWLTVLS---------EEDVAKEVDLMEAKYTDIIIYASGFLALVMAIV 497

  Fly   886 CVVTYICRQK-------------QKAKKETVKMTMAL----SGCEDSEPLRPSNIG-------AN 926
            .||  :||.:             ||..|..::...::    ||...:..:|.:.:.       |.
Zfish   498 IVV--LCRMQVHPSREPFDTLPVQKLSKFPLRRQYSVESNSSGKSSASLMRVARLSSSCSPMLAG 560

  Fly   927 LCKLRIVKDAE-------LRKGGVLGMGAFGRVYK----GVWVPEGENVKIPVAIKELLKSTGAE 980
            :.:..:..|.:       |..|..||.|.||:|.:    |: ..|.::....||:|.|......:
Zfish   561 VMEFELPYDPDWEFPRENLTLGKPLGEGCFGQVVRAEAYGI-NKENQDHMATVAVKMLKDDATDK 624

  Fly   981 SSEEFLREAYIMASVE-HVNLLKLLAVC-MSSQMMLITQLMPLGCLLDYVRNNR----------- 1032
            ...:.:.|..:|..:: |.|::.||.|| ....:.::.:....|.|.:|:|..|           
Zfish   625 DLADLISEMELMKVMDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGMDYTFDVT 689

  Fly  1033 ----DKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSN 1093
                :::..|.|::.:.|:|:||.||..||.:|||||||||||...:::||.|||||:.:.....
Zfish   690 KVPEEQLTFKDLVSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGLARGVHQIDY 754

  Fly  1094 EYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLK 1158
            ..|...|::|:||:|.|.:.:||:|.:||||:|||.:||:.|.|..|:..||.:::..|::.|.:
Zfish   755 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 819

  Fly  1159 LEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDE 1223
            :::|..|:.::|..:..|||.....|||||||.                              :|
Zfish   820 MDKPSNCTHELYMKMRECWHAVPTQRPTFKQLV------------------------------EE 854

  Fly  1224 KDLIRKLAPTTDGSEAIAEPDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGD 1284
            .|.:           .::..|:||            |.:....:.:..|:|.|:..||..|
Zfish   855 LDRV-----------LVSISDEYL------------DLSTPFEQYSPSCEDTSSSCSSDND 892

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032
GF_recep_IV 572..684 CDD:464344
FU 662..716 CDD:214589
GF_recep_IV 740..>834 CDD:464344 15/72 (21%)
PTKc_EGFR_like 930..1208 CDD:270648 95/305 (31%)
fgfr4XP_068071845.2 None
Blue background indicates that the domain is not in the aligned region.

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