DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30283 and HGF

DIOPT Version :9

Sequence 1:	NP_611587.2	Gene:	CG30283 / 37454	FlyBaseID:	FBgn0260477	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_000592.3	Gene:	HGF / 3082	HGNCID:	4893	Length:	728	Species:	Homo sapiens

Alignment Length:	255	Identity:	65/255 - (25%)
Similarity:	104/255 - (40%)	Gaps:	38/255 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LEHP---CGTVPISQFKILGGHNAPV-ASAPWMAMVMGEGGFHCGGTLITNRFVLTSAHCIANGE 89
            |:||   |...  .|.:::.|  .|. .:..||..:.......|||:||...:|||:..|..:.:
Human   480 LDHPVISCAKT--KQLRVVNG--IPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRD 540

  Fly    90 LK---VRLGVLEREAEAQKFAVDAMFVHTDYYFDQ-HDLALLRLAKRVHYSDNISPICLLLDPLV 150
            ||   ..||:.:......:.....:.|....|..: .||.|::||:..           :||..|
Human   541 LKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPA-----------VLDDFV 594

  Fly   151 KNID--------EHIVKFRTYGWGKTESRSSSRMLQKTSLFNLHRSECAKQYPHQ-QINRNHIC- 205
            ..||        ........||||.|...:...:|:...|:.:...:|::.:..: .:|.:.||
Human   595 STIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICA 659

  Fly   206 -AESANANTCNGDSGGPLTAIVTYDH-VQMVFQFGVTSFGHADCSKATVFTNVMTHLDWI 263
             ||...:..|.||.||||   |...| ::||....|...|.|..::..:|..|..:..||
Human   660 GAEKIGSGPCEGDYGGPL---VCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWI 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30283	NP_611587.2	Tryp_SPc	42..263	CDD:214473	58/237 (24%)
CG30283	NP_611587.2	Tryp_SPc	43..266	CDD:238113	60/238 (25%)
HGF	NP_000592.3	PAN_APPLE	39..122	CDD:238074
		KR	126..208	CDD:214527
		KR	210..290	CDD:214527
		KR	304..384	CDD:214527
		KR	388..470	CDD:238056
		Tryp_SPc	494..716	CDD:214473	58/237 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143003
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930