Protein Alignment MESK2 and NDRG4

DIOPT Version :9

• Sequence 1: NP_995914.1
• Gene: MESK2 / 37451
• FlyBaseID: FBgn0043070
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_001365261.1
• Gene: NDRG4 / 65009
• HGNCID: 14466
• Length: 434
• Species: Homo sapiens
• Alignment Length: 372
• Identity: 135/372 - (36%)
• Similarity: 185/372 - (49%)
• Gaps: 38/372 - (10%)

  Fly    47 EQRRVPTDKGDVHVAIQGDTA--KPAIITYHDLGLNYATSFAGFFNFPVMRGLLENFCVYHVTAP 109
            ::..:.|..|.:||.|:|...  :|||:||||:|||:...|..||||..|:.:.::|.|.||.||
Human    89 QEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAP 153

  Fly   110 GQEEGAPTLPEDYVYPTMDDLAAQLLFVLSHFGLKSVIGFGVGAGANILARFAHAHPDKVGALCL 174
            ||:.||...|:.|.:|:|:.|||.|..|:.|||.|.|||.||||||.:||:||...||.|..|.|
Human   154 GQQVGASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVL 218

  Fly   175 INCVSTQSGWIEWGYQSFNARFLRTKGMTQGVIDYLMWHHFGRNPEERNHDLVQMYKQHFERGVN 239
            :|......|||:|.       ..:..|:|..:.|.::.|.|.:.....|.:|||.|:|.....||
Human   219 VNIDPNGKGWIDWA-------ATKLSGLTSTLPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVN 276

  Fly   240 PTNLAMLINAYIHRNDLHLARTPPGTPGSETAATTLKMPVINITGSLSPHVDDTVTFNGRLDPTN 304
            ..||.:..|.|..|.||.:.|     ||:...|.||:.||:.:.|..:|..|..|..|.:||||.
Human   277 QANLQLFWNMYNSRRDLDINR-----PGTVPNAKTLRCPVMLVVGDNAPAEDGVVECNSKLDPTT 336

  Fly   305 SSWMKISDC-ALVLEEQPAKLAEAFRLFLQGEGYATPLSTPASSPCGTKYHTYSSIFFANFREQQ 368
            ::::|::|. .|....||.||.|||:.||||.||...|.....|  |....:.|....|..|...
Human   337 TTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIAYLKDRRLS--GGAVPSASMTRLARSRTAS 399

  Fly   369 QQAMEERDRERERERDRQRQLSLRVGNRLRETAINCTSSNSNTTAGQ 415
            ..:....|..|.:.                     ||.|.|:...||
Human   400 LTSASSVDGSRPQA---------------------CTHSESSEGLGQ 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MESK2	NP_995914.1	Abhydrolase	51..337	CDD:304388	119/288 (41%)
		MhpC	57..334	CDD:223669	115/279 (41%)
NDRG4	NP_001365261.1	Ndr	90..372	CDD:397285	121/293 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159732
Domainoid	1	1.000	241	1.000	Domainoid score	I2241
eggNOG	1	0.900	-	-		E1_KOG2931
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3252
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55737
OrthoDB	1	1.010	-	-		D359278at33208
OrthoFinder	1	1.000	-	-		FOG0000626
OrthoInspector	1	1.000	-	-		otm40323
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X370
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.910