Protein Alignment MESK2 and NDRG3

DIOPT Version :9

• Sequence 1: NP_995914.1
• Gene: MESK2 / 37451
• FlyBaseID: FBgn0043070
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: XP_006723900.1
• Gene: NDRG3 / 57446
• HGNCID: 14462
• Length: 388
• Species: Homo sapiens
• Alignment Length: 385
• Identity: 145/385 - (37%)
• Similarity: 210/385 - (54%)
• Gaps: 37/385 - (9%)

  Fly    20 VDPMDDIELRSVQ--LQFPNARGSILE-ACEQRRVPTDKGDVHVAIQG--DTAKPAIITYHDLGL 79
            :|.:.|::|..::  |...|...:..: .|::..:.|..|.|||.|:|  ...:|.|:||||:||
Human     1 MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETTHGVVHVTIRGLPKGNRPVILTYHDIGL 65

  Fly    80 NYATSFAGFFNFPVMRGLLENFCVYHVTAPGQEEGAPTLPEDYVYPTMDDLAAQLLFVLSHFGLK 144
            |:.:.|..||||..|:.:.::|.|.||.||||:||||:.|..|.|||||:||..|..||:|..||
Human    66 NHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLSLK 130

  Fly   145 SVIGFGVGAGANILARFAHAHPDKVGALCLINCVSTQSGWIEWGYQSFNARFLRTKGMTQGVIDY 209
            |:||.||||||.||:|||..||:.|..|.|||......|||:|...       :..|:|..|:|.
Human   131 SIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAAS-------KLSGLTTNVVDI 188

  Fly   210 LMWHHFGRNPEERNHDLVQMYKQHFERGVNPTNLAMLINAYIHRNDLHLARTPPGTPGSETAATT 274
            ::.||||:...:.|.||:|.|:.|..:.:|..||.:.:|:|..|.||.:.|  |....::..:.|
Human   189 ILAHHFGQEELQANLDLIQTYRMHIAQDINQDNLQLFLNSYNGRRDLEIER--PILGQNDNKSKT 251

  Fly   275 LKMPVINITGSLSPHVDDTVTFNGRLDPTNSSWMKISDC-ALVLEEQPAKLAEAFRLFLQGEGY- 337
            ||...:.:.|..||.|:..|..|.||:|.|::.:|::|| .|....||.||.|||:.||||.||
Human   252 LKCSTLLVVGDNSPAVEAVVECNSRLNPINTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYI 316

  Fly   338 ----ATPLSTPA-----------------SSPCGTKYHTYSSIFFANFREQQQQAMEERD 376
                .:.|||.:                 ||..|:....:|....:|..:..|::.|..|
Human   317 PYVQLSHLSTESVPSASMTRLARSRTHSTSSSLGSGESPFSRSVTSNQSDGTQESCESPD 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MESK2	NP_995914.1	Abhydrolase	51..337	CDD:304388	126/288 (44%)
		MhpC	57..334	CDD:223669	122/279 (44%)
NDRG3	XP_006723900.1	Ndr	32..317	CDD:397285	128/293 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159730
Domainoid	1	1.000	241	1.000	Domainoid score	I2241
eggNOG	1	0.900	-	-		E1_KOG2931
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40903
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3252
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55737
OrthoDB	1	1.010	-	-		D359278at33208
OrthoFinder	1	1.000	-	-		FOG0000626
OrthoInspector	1	1.000	-	-		otm40323
orthoMCL	1	0.900	-	-		OOG6_103361
Panther	1	1.100	-	-	O	PTHR11034
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5286
SonicParanoid	1	1.000	-	-		X370
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840