DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MESK2 and ndrg1

DIOPT Version :9

Sequence 1:	NP_995914.1	Gene:	MESK2 / 37451	FlyBaseID:	FBgn0043070	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001008146.1	Gene:	ndrg1 / 493508	XenbaseID:	XB-GENE-993273	Length:	395	Species:	Xenopus tropicalis

Alignment Length:	422	Identity:	150/422 - (35%)
Similarity:	208/422 - (49%)	Gaps:	79/422 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 EQRRVPTDKGDVHVAIQGDTA--KPAIITYHDLGLNYATSFAGFFNFPVMRGLLENFCVYHVTAP 109
            ::..:.|..|.|||.:.|...  :|.|:||||:|||:.|.|...|||..|..:.::|.|.||.||
Frog    33 QEHDIETAHGIVHVTMCGTPKLNRPVILTYHDIGLNHKTCFNSLFNFEDMHEITQHFSVCHVDAP 97

  Fly   110 GQEEGAPTLPEDYVYPTMDDLAAQLLFVLSHFGLKSVIGFGVGAGANILARFAHAHPDKVGALCL 174
            ||:|||.:.|..|:||:||.||..|..|:...|||||:|.|:||||.||.|||..||..|..|.|
Frog    98 GQQEGAASFPAGYMYPSMDQLAEMLPGVIQQLGLKSVLGLGIGAGAYILTRFALNHPSMVEGLVL 162

  Fly   175 INCVSTQSGWIEWGYQSFNARFLRTKGMTQGVIDYLMWHHFGRNPEERNHDLVQMYKQHFERGVN 239
            ||......||::|.       ..:..|.|..:.|.::.|.|.::....||:||:.|:||..:.:|
Frog   163 ININPCAEGWMDWA-------ATKISGWTHALPDMVISHLFSKDEVHSNHELVETYRQHIVQDIN 220

  Fly   240 PTNLAMLINAYIHRNDLHLARTPPGTPGSETAATTLKMPVINITGSLSPHVDDTVTFNGRLDPTN 304
            ..||.:.:.:|..|.||.:.|.   .|||.|  .|||.|.:.:.|..||.||..|..|.:||||.
Frog   221 QNNLQLFVKSYNSRRDLEIERP---FPGSNT--VTLKCPALLVVGDSSPAVDAVVDCNSKLDPTK 280

  Fly   305 SSWMKISDCA----LVLEEQPAKLAEAFRLFLQGEGYATPLSTPASSPCGTKYHTYSSIFFANFR 365
            ::.:|:|||.    :|   |||||||||:.|:||.||     .||:|
Frog   281 TTLLKMSDCGGFPQVV---QPAKLAEAFKYFVQGMGY-----MPAAS------------------ 319

  Fly   366 EQQQQAMEERDRERERERDRQRQLSLRVGNRLRETAINCTSSNSNTTAGQGDNNNADGRSVDGDD 430
                               ..|.:..|.|:....::.:...|.|:|      |..:..||..||
Frog   320 -------------------MTRLMRSRTGSAASSSSQDGNRSRSHT------NEGSRSRSHTGD- 358

  Fly   431 QDLENGNGCAGGNGTGTGNGNRAYVTTDTSGT 462
                 ||    .:...||:|||:...||::.|
Frog   359 -----GN----RSRAHTGDGNRSRSHTDSNNT 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESK2	NP_995914.1	Abhydrolase	51..337	CDD:304388	124/291 (43%)
MESK2	NP_995914.1	MhpC	57..334	CDD:223669	120/282 (43%)
ndrg1	NP_001008146.1	Ndr	34..316	CDD:251726	126/301 (42%)
		MhpC	88..311	CDD:223669	101/237 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..395		20/73 (27%)
		4 X 10 AA tandem repeats of G-[NS]-R-S-R-[AS]-H-T-[DGN]-[DES]. /evidence=ECO:0000255	339..378		16/54 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2430
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3330
OMA	1	1.010	-	-		QHG55737
OrthoDB	1	1.010	-	-		D359278at33208
OrthoFinder	1	1.000	-	-		FOG0000626
OrthoInspector	1	1.000	-	-		otm47498
Panther	1	1.100	-	-	O	PTHR11034
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5286
SonicParanoid	1	1.000	-	-		X370
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.110