DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MESK2 and ndrg4

DIOPT Version :9

Sequence 1:	NP_995914.1	Gene:	MESK2 / 37451	FlyBaseID:	FBgn0043070	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	XP_012816301.1	Gene:	ndrg4 / 448335	XenbaseID:	XB-GENE-941128	Length:	407	Species:	Xenopus tropicalis

Alignment Length:	423	Identity:	143/423 - (33%)
Similarity:	205/423 - (48%)	Gaps:	48/423 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 HTAEEAHLLGTMPVDPMDDIE-------LRSVQLQFPNARGSILEACE----QRRVPTDKGDVHV 60
            |..|...||..:.:..|.::.       ||....:..:| .:.|.|.:    :..:.|..|.:||
Frog    10 HGEERGLLLPDVSISGMSELRFPEEKPLLRGQDTEMESA-DTFLSAADTDWKEHDIETPYGMLHV 73

  Fly    61 AIQGDTA--KPAIITYHDLGLNYATSFAGFFNFPVMRGLLENFCVYHVTAPGQEEGAPTLPEDYV 123
            .|:|...  :|||:||||:|||:...|..|||:..|:.:.::|.|.||.||||:.||...|:.|.
Frog    74 VIRGTPKGNRPAILTYHDVGLNHKLCFNTFFNYEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQ 138

  Fly   124 YPTMDDLAAQLLFVLSHFGLKSVIGFGVGAGANILARFAHAHPDKVGALCLINCVSTQSGWIEWG 188
            ||||:.|||.|..|:.|||.:|:||.||||||.:||:||...|:.|..:.|:|......|||:|.
Frog   139 YPTMEQLAAMLPSVMQHFGFQSIIGIGVGAGAYVLAKFALIFPELVEGMVLVNIDPNGKGWIDWA 203

  Fly   189 YQSFNARFLRTKGMTQGVIDYLMWHHFGRNPEERNHDLVQMYKQHFERGVNPTNLAMLINAYIHR 253
            ..       :..|:|..:.:.::.|.|.:.....|.:|||.|:|.....||.:||.:..|.|..|
Frog   204 AS-------KLSGLTSSLPETVLSHLFSQEELMNNTELVQNYRQQISSCVNQSNLQLFWNMYNSR 261

  Fly   254 NDLHLARTPPGTPGSETAATTLKMPVINITGSLSPHVDDTVTFNGRLDPTNSSWMKISDC-ALVL 317
            .||.::|     ||:...|.||:.||:.:.|..:|..|..|..|.:|||||::::|::|. .|..
Frog   262 RDLEMSR-----PGTVPNAKTLRAPVMLVVGDNAPAEDCVVECNSKLDPTNTTFLKMADSGGLPQ 321

  Fly   318 EEQPAKLAEAFRLFLQGEGYATPLSTPASSPCGTKYHTYSSIFFANFREQQQQAMEERDRERERE 382
            ..||.||.|||:.||||.||...|.....|.......:.|....|..|.....:....|..|.|.
Frog   322 VTQPGKLTEAFKYFLQGMGYIASLKDRRQSASAGAVPSASMTRLARSRTASLTSASSVDGARPRP 386

  Fly   383 RDRQRQLSLRVGNRLRETAINCTSSNSNTTAGQ 415
                                 ||.|.|:...||
Frog   387 ---------------------CTQSESSDGIGQ 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESK2	NP_995914.1	Abhydrolase	51..337	CDD:304388	117/288 (41%)
MESK2	NP_995914.1	MhpC	57..334	CDD:223669	113/279 (41%)
ndrg4	XP_012816301.1	Ndr	61..343	CDD:251726	119/293 (41%)
ndrg4	XP_012816301.1	protocat_pcaD	70..337	CDD:131480	112/278 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2430
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3330
OMA	1	1.010	-	-		QHG55737
OrthoDB	1	1.010	-	-		D359278at33208
OrthoFinder	1	1.000	-	-		FOG0000626
OrthoInspector	1	1.000	-	-		otm47498
Panther	1	1.100	-	-	O	PTHR11034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X370
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080