Protein Alignment MESK2 and Ndrg2

DIOPT Version :9

• Sequence 1: NP_995914.1
• Gene: MESK2 / 37451
• FlyBaseID: FBgn0043070
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_001347193.1
• Gene: Ndrg2 / 29811
• MGIID: 1352498
• Length: 374
• Species: Mus musculus
• Alignment Length: 386
• Identity: 130/386 - (33%)
• Similarity: 184/386 - (47%)
• Gaps: 57/386 - (14%)

  Fly     1 MPSAPTHTAEEAHLLGTMPVDPMDDIELRSVQLQFPNARGSILEACEQRRVPTDKGDVHVAIQG- 64
            :|.....||:||.|                       |...:|:..:...|.|..|.|...:.|
Mouse    19 LPGQTPETAKEAEL-----------------------AARILLDQGQTHSVETPYGSVTFTVYGT 60

  Fly    65 -DTAKPAIITYHDLGLNYATSFAGFFNFPVMRGLLENFCVYHVTAPGQEEGAPTLPEDYVYPTMD 128
             ...:|||.||||:||||.:.|...|.|..|:.:::||...||.|||.|||||..|..|.||::|
Mouse    61 PKPKRPAIFTYHDVGLNYKSCFQPLFRFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLD 125

  Fly   129 DLAAQLLFVLSHFGLKSVIGFGVGAGANILARFAHAHPDKVGALCLINCVSTQSGWIEWGYQSFN 193
            .||..:..:|.:....::||.||||||.||:|:|..|||.|..|.|||......||::|...
Mouse   126 QLADMIPCILQYLNFSTIIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPNAKGWMDWAAH--- 187

  Fly   194 ARFLRTKGMTQGVIDYLMWHHFGRNPEERNHDLVQMYKQHFERGVNPTNLAMLINAYIHRNDLHL 258
                :..|:|..:.|.::.|.|.:.....|.:|:|.|:...:...|..|:.:..|:|.:|.||:.
Mouse   188 ----KLTGLTSSIPDMILGHLFSQEELSGNSELIQKYRGIIQHAPNLENIELYWNSYNNRRDLNF 248

  Fly   259 ARTPPGTPGSETAATTLKMPVINITGSLSPHVDDTVTFNGRLDPTNSSWMKISDCALVLE-EQPA 322
            .|      |.|   ||||.||:.:.|..:||.|..|..|.:||||.:|::|::|.....: .||.
Mouse   249 ER------GGE---TTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPG 304

  Fly   323 KLAEAFRLFLQGEGYATPLSTPASSPCGTKYHTYSSIFFANFREQQQQAMEERDRERERER 383
            ||.|||:.||||.||       .:|.|.|:        .:..|.....:....|..|.|.|
Mouse   305 KLTEAFKYFLQGMGY-------MASSCMTR--------LSRSRTASLTSAASIDGSRSRSR 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MESK2	NP_995914.1	Abhydrolase	51..337	CDD:304388	112/288 (39%)
		MhpC	57..334	CDD:223669	107/279 (38%)
Ndrg2	NP_001347193.1	Ndr	43..321	CDD:251726	114/300 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850101
Domainoid	1	1.000	234	1.000	Domainoid score	I2376
eggNOG	1	0.900	-	-		E1_KOG2931
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I3317
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55737
OrthoDB	1	1.010	-	-		D359278at33208
OrthoFinder	1	1.000	-	-		FOG0000626
OrthoInspector	1	1.000	-	-		otm42388
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11034
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5286
SonicParanoid	1	1.000	-	-		X370
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.940