Protein Alignment KCNB1 and Shawl

DIOPT Version :9

• Sequence 1: NP_004966.1
• Gene: KCNB1 / 3745
• HGNCID: 6231
• Length: 858
• Species: Homo sapiens
• Sequence 2: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Alignment Length: 966
• Identity: 251/966 - (25%)
• Similarity: 372/966 - (38%)
• Gaps: 293/966 - (30%)

Human    32 RVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDC-NTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSI 95
            |:.|||.|:.:|....||.::|.|||.:|.:. ..:|.:|          ||||||||||.||.|
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVL----------NEYFFDRHPGVFTQI 60

Human    96 LNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMN-----EELKREAETL 155
            ||:||||:||...::|...|.:||::||:|...:|.||.:.|...::..|     ::|..|.|..
  Fly    61 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKP 125

Human   156 RERE-------GEEFDN---TCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNT 210
            .|.:       .|...|   .|....:.|:|.:.::|:||..|||:|.:|:.||.:|.|:..|.|
  Fly   126 TEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKT 190

Human   211 LPELQ------SLDEFGQSTDNPQLAH-------------------------------------- 231
            .|..:      :.|..|.....|...|
  Fly   191 HPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSS 255

Human   232 ----------------------------------------------------------------V 232
                                                                            |
  Fly   256 GNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYV 320

Human   233 EAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQ 297
            |.||..||.:|.::|.:.||..|:|.|.|:|.||..|.|.:|..:        :.:......:::
  Fly   321 ELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV--------MQRMGEYTGLLE 377

Human   298 IFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK--DEDDTK 360
            .|.|:||:|:.||.|||.||:.|..|.:.|..||.||:.||.:||:.|:||.::|||  |..|.:
  Fly   378 AFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQ 442

Human   361 FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE-QK 424
            |||||...|||.:|||||||||:.|||..|..||.||.:||||.||||:|:||:|||.||.. |.
  Fly   443 FKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQA 507

Human   425 RQEKAIKRREAL----ERAKRN------------------------GSIVSMN------------ 449
            |.:...|||..|    .|.||.                        |.:|.:.
  Fly   508 RSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVVPVGAGGPGLGGHAVG 572

Human   450 --------MKDAF-ARSIEMMDIVVEKNGEN-----------------MGKKDKV---------- 478
                    .|||| ...|..:::    ||.|                 |.:.|..
  Fly   573 HSAAGAPMFKDAFGGAKIGTVNV----NGVNVIGLHPAQRTTTTMAMAMNEADPTPMSALTYQVP 633

Human   479 ----------QDNH-------LSPNKWKWT-KRTLSETSSSKSFETKEQGSPEKARSSSSPQHLN 525
                      ...|       |.|.....| ..:|:.:::|.:..|....:| ...|..|..:|:
  Fly   634 MLQPTPTPAHSHGHAHGHAHGLGPASAAMTSSASLTGSAASAAVATAAAAAP-AGPSFISSDYLS 697

Human   526 VQQLEDMYNKMAKTQSQPILNTKESAAQSK---PKEELEMESIPSPVAPLPTRTEGVI---DMRS 584
            |..::.:..:.|.|....:|     ..|.|   |.|..:...:......|.:.|..::   ...|
  Fly   698 VPAVQSLQPRAATTGHDFML-----PLQPKLLGPLERKDQHPLQLTAHNLASDTHQLMYSGHAHS 757

Human   585 MSSIDSFISCATDFPEATRFSHSPLTSLPS--KTGGSTAPEVGWRGALGASGGRFVEANPSPDA- 646
            ...:... :...:.|.....||   |.:|.  .:.|...|.:.:|.|.|||........|.|.:
  Fly   758 QHKVGGG-AAVLNVPPTLSMSH---TQMPPGIASMGQRTPNLSFRPAHGASSQVATVQQPIPHSH 818

Human   647 SQHSSFFIESPKSSMKTNNPLKLRALKVNFMEGDP----SPLLPVLGMYHDPLRNRGSAAAAVAG 707
            :.|:|           ||..:|:.........|.|    :|.:.:|    |.|.:..:::....|
  Fly   819 ACHAS-----------TNCNIKISVASAGLSVGCPDEFRTPKVTLL----DDLSDDVNSSTDDCG 868

Human   708 LECATLLDKAVLSPESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDE 763
             :|. |:|      :|..|...:....|...|..|. |...:.|:   :|.|.:||
  Fly   869 -DCC-LVD------DSDTYEGTTINNGPSGQENGTE-AIGLDDGL---LDNDGEDE 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNB1	NP_004966.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		BTB_POZ_KCNB2	15..141	CDD:349719	47/109 (43%)
		Self-association. /evidence=ECO:0000250|UniProtKB:P15387	59..75		3/16 (19%)
		Ion_trans	188..424	CDD:395416	108/346 (31%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	377..382		4/4 (100%)
		Self-association. /evidence=ECO:0000250|UniProtKB:P15387	448..481		10/90 (11%)
		Kv2channel	467..679	CDD:397541	46/265 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..524		13/97 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..574		7/38 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	770..807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	836..858
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	44/101 (44%)
		BTB_2	7..97	CDD:280393	43/99 (43%)
		Ion_trans	307..506	CDD:278921	92/206 (45%)
		Ion_trans_2	<449..499	CDD:285168	32/49 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810